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| 1 | FSPM-P: towards a general functional-structural plant model for robust and comprehensive model development显示文摘在最后十年,功能结构的植物建模(FSPM ) 在庄稼和树生产成为了一个更广泛地接受的范例,当为最重要的庄稼的 3D 模型被建议了。给可得到的模型的更宽的公事包,在 FSPM 开发进入下一水平现在是适当的,由为模型开发介绍更有效的方法。这包括模型复用的考虑(由 modularisation ) ,联合和比较,和存在的改进当模特儿。便于这个过程,为设计的标准和要定义并且建立的通讯需要。我们在场第一步向一有效、一般,即,不是 speciesspecific FSPM,目前限制了为年度或每年两次的植物,但是与为扩展和进一步的归纳的潜力。模型结构是层次、面向对象的,与是的植物机关底级的目标和植物个人和华盖高度级的目标。,为生理的过程的多数的模块在有一个类似的目的另外的平台被合并(例如,光合作用,器官形成和生长) 。有从文学采用的几个一般参数集合的模拟跑证明能复制嘴巧的产量的现在的 prototypewas 为不同庄稼变化(油菜籽,大麦,等等)以动力学和最后的值(在收获时间)模型状态变量例如吸收生产,机关生物资源,叶区域和体系结构。 | Michael HENKE Winfried KURTH Gerhard H. BUCK-SORLIN | 2016 | Frontiers of Computer Science2016，10，6： | 5 |
| 2 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses: The Wingspan Study显示文摘 | Arani Bose Marius Hartmann Hans Henkes Hon Man Liu Michael M.H. Teng Istvan Szikora Ansgar Berlis Jurgen Reul Simon C.H. Yu Michael Forsting Matt Lui Winston Lim Siu Po Sit | 2007 | Stroke2007，，5： | 1 |
| 4 | A Novel, Self-Expanding, Nitinol Stent in Medically Refractory Intracranial Atherosclerotic Stenoses: The Wingspan Study显示文摘 | Arani Bose Marius Hartmann Hans Henkes Hon Man Liu Michael M.H. Teng Istvan Szikora Ansgar Berlis Jurgen Reul Simon C.H. Yu Michael Forsting Matt Lui Winston Lim Siu Po Sit | 2007 | Stroke2007，，5： | 1 |
| 5 | Space–Time Patterns of Risk: A Cross National Assessment of Residential Burglary Victimization显示文摘 | Shane D. Johnson Wim Bernasco Kate J. Bowers Henk Elffers Jerry Ratcliffe George Rengert Michael Townsley | 2007 | Journal of Quantitative Criminology2007，，3： | 1 |
| 6 | Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial显示文摘 | Michael Henke Roland Laszig Christian Rübe Ulrich Sch?fer Klaus-Dieter Haase Burkhard Schilcher Stephan Mose Karl T Beer Ulrich Burger Chris Dougherty Hermann Frommhold | 2003 | The Lancet2003，，9392： | 1 |
| 7 | Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy显示文摘 | Brenda Gerull John Atherton Anke Geupel Sabine Sasse-Klaassen Arnd Heuser Michael Frenneaux Mark McNabb Henk Granzier Siegfried Labeit Ludwig Thierfelder | 2006 | Journal of Molecular Medicine2006，，6： | 1 |
| 8 | Moist Skin Care Can Diminish Acute Radiation-Induced Skin Toxicity显示文摘 | Felix Momm MD Christian Wei?enberger Susanne Bartelt Michael Henke | 2003 | Strahlentherapie und Onkologie2003，，10： | 1 |
| 9 | A New Look at the Psychometric Paradigm of erception of Hazards显示文摘 | Carmen Keller Henk A L Kiers | 2005 | Risk Analysis2005，，25： | 1 |
| 10 | Blood Hemoglobin Level and Treatment Outcome of Early Breast Cancer显示文摘 | PD Michael Henke MD Florian Sindlinger Hans Ikenberg Thomas Gerds Martin Schumacher | 2004 | Strahlentherapie und Onkologie2004，，1： | 1 |
| 11 | Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial显示文摘 | Michael Henke Roland Laszig Christian Rübe Ulrich Sch?fer Klaus-Dieter Haase Burkhard Schilcher Stephan Mose Karl T Beer Ulrich Burger Chris Dougherty Hermann Frommhold | 2003 | The Lancet2003，，9392： | 1 |
| 12 | Specific Mutations in ABCA1 Have Discrete Effects on ABCA1 Function and Lipid Phenotypes Both In Vivo and In Vitro显示文摘 | Roshni R. Singaraja Henk Visscher Erick R. James Angeliki Chroni Jonathan M. Coutinho Liam R. Brunham Martin H. Kang Vassilis I. Zannis Giovanna Chimini Michael R. Hayden | 2006 | Circulation Research2006，，4： | 1 |
| 13 | Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia显示文摘 | Charles L Bennett Michael Henke | 2008 | JAMA2008，299，8： | 1 |
| 14 | Tumor Exome Analysis Reveals Neoantigen-Specific T-Cell Reactivity in an Ipilimumab-Responsive Melanoma显示文摘 | Nienke van Rooij Marit M. van Buuren Daisy Philips Arno Velds Mireille Toebes Bianca Heemskerk Laura J.A. van Dijk Sam Behjati Henk Hilkmann Dris el Atmioui Marja Nieuwland Michael R. Stratton Ron M. Kerkhoven Can Ke?mir John B. Haanen Pia Kvistborg Ton N | 2013 | Journal of Clinical Oncology2013，，： | 1 |
| 15 | Treatable causes of fever among children under five years in a seasonal malaria transmission area in Burkina Faso显示文摘Background:Fever remains a major public health problem.In Burkina Faso,more than half of febrile children are considered not to be infected by malaria.This study prospectively assessed probable(treatable)causes of fever in Burkinabe children.Methods:A prospective study was conducted among febrile children(≥37.5°C)under 5 years of age presenting at four health facilities and one referral hospital in rural Burkina Faso.From each participant,blood was collected for malaria microscopy and culture,urine for dipstick testing and culturing if tested positive for leucocytes and nitrite,stool for rotavirus/adenovirus testing,culture and parasitology,and a nasopharyngeal swab for culture.Results:In total 684 febrile children were included in the study.Plasmodium falciparum malaria was found in 49.7%(340/684)of the participants and non-malaria infections in 49.1%(336/684)of children.The non-nalaria infections included gastro-intestinal infections(37.0%),common bacterial pathogens of nasopharynx(24.3%),bacterial bloodstream infections(6.0%)and urinary tract infections(1.8%).Nearly 45%(154/340)of the malaria infected children were co-infected with non-nalaria infections,but only 3.2%(11/340)of these co-infections could be considered as a possible alternative cause of fever.In contrast,in the malaria microscopy negative children 18.0%(62/344)of the infections could be the probable cause of the fever.Pathogens were not isolated from 23.7%(162/684)of the febrile cases.Conclusions:Malaria remains the most common pathogen found in febrile children in Burkina Faso.However,a relative high number of febrile children had non-malaria infections.The correct diagnosis of these non-malaria fevers is a major concern,and there is an urgent need to develop more point-of-care diagnostic tests and capacities to identify and treat the causes of these fevers. | Francois Kiemde Marc Christian Tahita Palpouguini Lompo Toussaint Rouamba Athanase M.Some Halidou Tinto Petra F.Mens Henk D.F.H.Schallig Michael Boele van Hensbroek | 2018 | Infectious Diseases of Poverty2018，7，1： | 0 |
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