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43篇 您的检索式：作者名="HERFARTH C"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Quality of life and functional results following different types of resection for gastric carcinoma显示文摘	Buhl K Schlag P Herfarth C	1990	Eur J Surg Oncol1990，16，4：	1
3	Imaging diagnosis for staging of gastric cancer显示文摘	Kuntz C Herfarth C	1999	Seminars in Surgical Oncology1999，17，2：	1
4	Endorectal ultrasonography for the assessment of invasion of rectal tumours and lymph node invol-vement显示文摘	Glaser F Schlag P Herfarth C	1990	Br J Surg1990，77，8：	1
5	Duodenal adenomatosis in familial adenomatou s polyposis coli:a review of the literature and results from the Heidelberg polyposis register显示文摘	Kadmon M Tandara A Herfarth C	2001	Int J Colorectal Dis2001，16，：	1
6	Surgical procedures for gastric substitution显示文摘	Herfarth C Schlag P Buhl K	1987	World J Surg1987，11，6：	1
7	Imaging diagnosis for staging of gastric cancer显示文摘	Kuntz C Herfarth C	1999	Seminars in Surgical Oncology1999，17，2：	1
8	Endorectal ultrasonography for the assessment of invasion of rectal tumours and lymph node involvement 显示文摘	Schlag P Herfarth C	1990	Br J Surg1990，77，8：	1
9	Imaging diagnosis for staging of gast- ric cancer显示文摘	Kuntz C Herfarth C	1999	Semin Surg Oncol1999，17，2：	1
10	Effect of diagnostic imaging tech- niques on choice of therapy and prognosis of traumatic pancreas and duodenal injuries 显示文摘	Riedl S Buhr HJ Herfarth C	1994	Langenbecks Arch Chir1994，379，：	1
11	Imaging diagnosis for staging of gastric cancer显示文摘	Kuntz C Herfarth C	1999	Semin Surg Oncol1999，17，2：	1
12	Cancer and dyspla-sia in ulcerative colitis : a histologic study of 301 surgicalspecimen显示文摘	von Herbay A Herfarth C Otto HF	1994	Z Gastroenterol1994，32，：	1
13	Effect of diagnostic imaging tech- niques on choice of therapy and prognosis of traumatic pancreas and duodenal injuries显示文摘	Riedl S Buhr HJ Herfarth C	1994	Langenbecks Arch Chir1994，579，1：	1
14	Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter 显示文摘	Hinz U Walczak H Mechtersheimer G Koretz K Herfarth C Moller P Lehnert T	2002	Clin Cancer Res2002，8，12：	1
15	Surgical strategies and minimal residualdisease detection 显示文摘	Weitz J Herfarth C	2001	Semin Surg Oncol2001，20，32：	1
16	Duodenal Adenmatosis in Familial Adenomatous Polyposis Coli:a Review of the Literature And Results from the Heidelberg Polyposis Register显示文摘	KADMON M TANDARA A HERFARTH C	2001	Int J Colorectal Dis2001，16，：	1
17	The effect of virtual reality and training on liver operation planning 显示文摘	Herfarth C LamadeW Fischer L	2002	Swiss Surg2002，8，2：	1
18	Endorectal ultrasonography for the assessment of invasion of rectal tumours and lymph node involvement显示文摘	Glaser F Schlag P Herfarth C	1990	Br J Surg1990，77，8：	1
19	Principies and value of lymph node excision in colorectal carcinoma 显示文摘	Lehnert T Herfarth C	1996	Chirurg1996，67，9：	1
20	Endorectal uhrasonography for the assessment of invasion of rectal tumours and lymph node involvement显示文摘	Glaser F Schlag P Herfarth C	1990	Br J Surg1990，77，8：	1

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