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		题名	作者	年代	出处	被引量
	1	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
	2	Nutritive characheristics of different varieties of sorghum and corn grains显示文摘	HIBBERD C A WAGNER D G SCHEMM R L	1982	Journal of Animal Science1982，55，：	1
	3	Occurrence of the rare A2 mating type of Phytophthora infestans on imported Egyptian potatoes and the produetion of sexual progeny with A1 mating types from the UK显示文摘	Shaw D S Fyfe A M Hibberd P G Abdel-Sattar M A		0，，04：	1
	4	Clinically relevant fatigue in cancer outpatients,the Edinburgh Cancer Centre symptom study显示文摘	Storey D J Waters R A Hibberd C J	2014	Ann Oncol2014，18，2：	1
	5	Breeding disease resistant Capsicum for wide adaptation显示文摘	Hibberd A M Persley D M Nahrund G C	1989	Acta Hor tic1989，247，：	1
	6	Castanospermine, an oligosaccharide pro- cessing inhibitor, reduces membrane expression of adhesion molecules and prolongs heart allograft sur- vival in rats 显示文摘	GROCHOWICZ P M HIBBERD A D SMART Y C	1996	Transplant Immunol1996，4，4：	1
	7	Effect of surface emissivity on furnace performance 显示文摘	Elliston D G Gray W A Hibberd D F	1987	Journal of the Institute of Energy1987，60，：	1
	8	2001, Many parallel losses of infA from chloroplast DNA during angiosperm evolution with multiple independent transfers to the nucleus 显示文摘	Millen R S Olmstead R G Adams K L Palmer J D Lao N T Heggie L Kavanagh T A Hibberd J M Gray J C Morden C W Calie P J Jermiin L S Wolfe K H	2001	Plant Cell2001，13，3：	1
	9	Effect of variety of sorghum grain on digestion and availability of dry matter and starch in vitro 显示文摘	STREETER M N WAGNER D G HIBBERD C A	1990	Ani- mal Feed Science and Technology1990，29，3：	1

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