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	题名	作者	年代	出处	被引量
1	Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation显示文摘AIM: To investigate the interaction between castanospermine and cyclosporin A(Cs A) and to provide an explanation for it.METHODS: The alkaloid castanospermine was prepared from the seeds of Castanospermum austral consistently achieving purity. Rat heterotopic cardiac transplantation and mixed lymphocyte reactivity were done using genetically inbred strains of PVG(donor) and DA(recipient). For the mixed lymphocyte reaction stimulator cells were irradiated with 3000 rads using a linear accelerator. Cyclosporin A was administered by gavage and venous blood collected 2 h later(C_2). The blood levels of Cs A(Neoral) were measured by immunoassay which consisted of a homogeneous enzyme assay(EMIT) on Cobas Mira. Statistical analyses of interactions were done by an acceleratedfailure time model with Weibull distribution for allograft survival and logistic regression for the mixed lymphocyte reactivity.RESULTS: Castanospermine prolonged transplant survival times as a function of dose even at relatively low doses. Cyclosporin A also prolonged transplant survival times as a function of dose particularly at doses above 2 mg/kg. There were synergistic interactions between castanospermine and Cs A in the prolongation of cardiac allograft survival for dose ranges of Cs A by castanospermine of(0 to 2) mg/kg by(0 to 200) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) and(0 to 3) mg/kg by(0 to 100) mg/kg(HR = 0.986; 95%CI: 0.981-0.992; P < 0.001) respectively. The addition of castanospermine did not significantly increase the levels of cyclosporin A on day 3 or day 6 for all doses of Cs A. On the contrary, cessation of castanospermine in the presence of Cs A at 2 mg/kg significantly increased the Cs A level(P = 0.002). Castanospermine inhibited mixed lymphocyte reactivity in a dose dependent manner but without synergistic interaction. CONCLUSION: There is synergistic interaction between castanospermine and Cs A in rat cardiac transplantation. Neither the mixed lymphocyte reaction nor the metabolism of Cs A provides an explanation.	Adrian D Hibberd David A Clark Paul R Trevillian Patrick Mcelduff	2016	World Journal of Transplantation2016，6，1：	2
2	Localization of photosynthetic metabolism in the parasitic angiosperm Cuscuta reflexa显示文摘	HIBBERD J M BUNGARD R A PRESS M C	1998	Planta1998，205，：	1
3	Chloramphenicol versus ampicillin plus gentamicin for community acquired very severe pneumonia among children aged 2- 59 months in low resource settings: multicentre randomised controlled trial (SPEAR study)显示文摘	Asghar R Banajeh S Egas J Hibberd P lqbal I Katep-Bwalya	2008	BMJ2008，336，7635：	1
4	Cytology and ultraslructure of Chlorarachnion reptans (Chlorarachniophyta divisio nova, Chlorarachniophyceae classis nova) 显示文摘	Hibberd D J Norris R E	1984	J Phycol1984，20，：	1
5	Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis 显示文摘	Davila S Hibberd ML Hari Dass R Wong HE Sahiratmadja E Bonnard C	2008	PLoS Genet2008，4，10：	1
6	Tai Chi for treating knee osteoarthritis:designing a long-term follow up randomized controlled trial显示文摘	Wang C Schmid CH Hibberd PL Kalish R Roubenoff R Rones R		0，，：	1
7	Accuracy of three dimensional echocardiographic with unrestricted selection of imaging planes for measurement of left ventricular volumes and ejection fraction 显示文摘	HIBBERD M G CHUANG M L BEAUDIN R A	2000	Am Heart2000，140，2：	1
8	Risk and protective factors for posttraumatic stress disorder, prolonged grief, and depression in survivors of the violent death of a loved one 显示文摘	HIBBERD R ELWOOD L S GALOVSKI T E	2010	Journal of Loss and Trauma International Perspectives on Stress and Coping2010，15，5：	1
9	Partition of endocrine-disrupting chemicals between colloids and dissolved phase as determined by cross-flow ultrafiltration显示文摘	Liu R Wilding A Hibberd A	2005	Environ Sci Technol2005，39，：	1
10	Partition of endocrine disrupting chemicals between colloids and dissolved phase as determined by cross- flow ultrafihration 显示文摘	Liu R Wilding A Hibberd A	2005	Environ Sci Technol2005，39，：	1
11	Nutritive characheristics of different varieties of sorghum and corn grains显示文摘	HIBBERD C A WAGNER D G SCHEMM R L	1982	Journal of Animal Science1982，55，：	1
12	Robot Assisted Knee Surgery显示文摘	Hibberd R D	1995	IEEE Engineering in Medicine and Biology1995，，：	1
13	Accuracy of three-dimensional echocardiography with unrestricted selection of imaging planes for measurement of left ventricular volumes and ejection fraction 显示文摘	Hibberd M G Chuang M L Beaudin R A	2000	Am Heart J2000，140，：	1
14	Genetic association and expression studies indicate a role of Toll-like receptor 8 in pulmonary tuberculosis显示文摘	DAVILA S HIBBERD M L DASS R H		0，，10：	1
15	Tai Chi is effective in treating knee osteoarthritis:a randomized controlled trial显示文摘	Wang C Schmid CH Hibberd PL Kalish R Roubenoff R Rones R		0，，：	1
16	Management of depressionfor people with cancer(SMaRT oncology 1):a randomised trial显示文摘	Strong V Waters R Hibberd C	2008	Lancet2008，372，9632：	1
17	Unusual carotenoid composition and a new type of xanthophylls cycle in plants显示文摘	Bungard R A Ruban A V Hibberd J M	1999	Proc Natl Acad Sci USA1999，96，：	1
18	Allelism tests of three dominant genes for hypersensitive resistance to bacterial spot of pepper显示文摘	HIBBERD A M BASSETT M J STALL R E	1987	Phytopathology1987，77，：	1
19	Clinically relevant fatigue in cancer outpatients,the Edinburgh Cancer Centre symptom study显示文摘	Storey D J Waters R A Hibberd C J	2014	Ann Oncol2014，18，2：	1
20	Tissue - spe- cific and developmental - specific expression of an Arabi- dopsis thaliana gene encoding the lipoamide dehydrogen- ase component of the plastid pyruvate dehydrogenase com- plex 显示文摘	Drea S C Mould R M Hibberd J M	2001	Plant Molecular Biology2001，46，6：	1

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