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| 1 | A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B显示文摘Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal outcome.In this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and corticosteroid.In both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became undetectable.Entecavir treatment was continued.Generally,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few weeks.During this time lag,liver cell injury continued and the disease progressed.Corticosteroid suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B. | Kazuyuki Matsumoto Yasuhiro Miyake Hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，13： | 16 |
| 2 | A case of hepatic angiomyolipoma difficult to distinguish from hepatocellular carcinoma显示文摘We report a case of hepatic angiomyolipoma with uncommon clinical features. A 56-year-old man presented with a hepatic tumor in the caudate lobe. The tumor was hypoechoic on ultrasonography, showed early-phase hyperattenuation on enhanced computed tomography and did not absorb iron on superparamagnetic iron oxide-enhanced magnetic resonance imaging. Hepatocellular carcinoma was highly suspected, and the patient underwent hepatic resection. Histologically, the tumor was mainly composed of smooth muscle cells and contained small amounts of adipose cells and blood vessels. On immunohistochemical staining, the smooth muscle cells were positive for a melanocytic cell-specific monoclonal antibody. In cases with uncommon features of angiomyolipoma, it is quite difficult to distinguish angiomyolipoma from hepatocellular carcinoma. | Masahiro Takahara Yasuhiro Miyake Kazuyuki Matsumoto Daisuke Kawai Eisuke Kaji Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata | 2009 | World Journal of Gastroenterology2009，15，23： | 8 |
| 3 | Anti-amyloidogenic effects of soybean isoflavones in vitro : Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils显示文摘 | Mie Hirohata Kenjiro Ono Jun-ichi Takasaki Ryoichi Takahashi Tokuhei Ikeda Akiyoshi Morinaga Masahito Yamada | 2012 | BBA - Molecular Basis of Disease2012，，8： | 3 |
| 4 | Electroluminescence in conducting polymers based on poly(phenylene ethynylene) 显示文摘 | M Hirohata K Tada T Kawai | 1997 | Synthetic Metal1997，85，： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Ferulic acid destabilizes preformed β-amyloid fibrils in vitro 显示文摘 | ONO K HIROHATA M YAMADA M | 2005 | Biochem Biophys Res Comm2005，336，3： | 1 |
| 7 | Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with ischemic heart disease显示文摘 | Miyoshi T Doi M Hirohata S | 2010 | Atherosclerosis and Thrombosis2010，17，3： | 1 |
| 8 | Photoluminescence and electroluminescence in polyacetylene derivatives 显示文摘 | Yoshino K Hirohata M Hidayat R | 1999 | Synthetic Metals1999，102，： | 1 |
| 9 | Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix 显示文摘 | Hirohata S Wang LW Miyagi M | 2002 | JBiol Chem2002，277，12： | 1 |
| 10 | Behcet's disease 显示文摘 | Hirohata S Kikuchi H | 2003 | Arthritis Res Ther2003，5，3： | 1 |
| 11 | Estrogen Has Anti-amyloidogenic Effects on Alzheimer' s Beta-amyloid Fibrils in Vitro 显示文摘 | MORINAGA A HIROHATA M ONO K | 2007 | Biochem Biophys Res Commun ( S0006 - 291X)2007，359，3： | 1 |
| 12 | Cardio - ankle vascu- lar index is independently associated with the severity of coronary atheroselerosis and left ventrieular function in patients with ischemic heart disease显示文摘 | MIYOSHI T DOI M HIROHATA S | 2010 | J Atheroscler Thromb2010，17，3： | 1 |
| 13 | Influ- ence of alcohointake, cigarette smoking and occupational status on idliopathic osteonecro- sis of Lhe femoral head显示文摘 | MaLsuo K Hirohata T Sugio ka Y | 1988 | Clin O rthop1988，，： | 1 |
| 14 | Influence of alcohol intake,cigarette smoking,and occupational status on idiopathic osteonecrosis of the femoral head显示文摘 | Matsuo K Hirohata T Sugioka Y | | 0，，09： | 1 |
| 15 | Angioneogenesis as a possible elusive trigger factor in rheumatoid arthritis显示文摘 | HIROHATA S SAKAKIBARA J | 1999 | Lancet1999，353，9161： | 1 |
| 16 | Influence of alcohol intake,cigarette smoking,and occupational status on idiopathic osteonecrosis of the femoral head显示文摘 | Matsuo K Hirohata T Sugioka Y | | 0，，234： | 1 |
| 17 | Steriod-induced accumulation of lipid in the osteocytes of the rabbit femoral head:a histochemical and electron microscopic study显示文摘 | KAWAI K TAMAKI A HIROHATA K | 1985 | J Bone Joint surg1985，67，5： | 1 |
| 18 | Synthesis and radical polymerization of N,N-diethyl-α-fluoroacrylamide显示文摘 | T Sato S Hirohata T Fujimoto | 2001 | European Polymer Journal2001，37，2： | 1 |
| 19 | A hospital-based case-control study on hepatocellular carcinoma in Fukuoka and Saga Prefectures, northern Kyushu, Japan显示文摘 | Fukuda K Shibata A Hirohata I | 1993 | Jpn J Cancer Res1993，84，： | 1 |
| 20 | Hydrogen Desorption Behavior of Aluminium Materials Used for Extremely High Vacuum Chamber显示文摘 | Hirohata Y Fujimoto S Hino T | 1993 | J Vac1993，11，5： | 1 |
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