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	题名	作者	年代	出处	被引量
1	Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy.	Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi	2016	World Journal of Gastroenterology2016，22，44：	5
2	Exhaled nitric oxide as a simple assessment of airway hyperresponsiveness in bronchial asthma and chronic cough patients 显示文摘	Hiroko N Shunsuke S Sankei N	2003	J Asthma2003，40，6：	1
3	Functions and Potential Applications of Glycolipid Biosurfactants from Energy Saving Materials to Gene Delivery Carriers显示文摘	DAI K HIROKO I TADAATSU N	2002	J Biosci Bioeng2002，94，3：	1
4	Characterization of cold-respon- sive extracellular chitinase in bromegrass cell cultures,its relationship to anti- freeze activity显示文摘	Toshihide N Masaya I Hiroko N	2008	Plant Physiology2008，147，1：	1
5	Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity显示文摘	VOLALUCK S HIROKO U ATSUHITO N	2002	J Clin Invest2002，109，10：	1
6	Prevent ion of Biofilm Formation with a Coating of 2-Methacryloyloxyethyl Phosph orylcholine Polymer显示文摘	KIYOHISA F U HIROKO N MATSUMOTOY	2008	J Vet MedSci2008，70，2：	1
7	Identification of potential biomarkers of lymphnede metastasis in oral squamous cell carcinoma by cDNA microarray analysis显示文摘	Hajime F Hiroko IDA	2003	Int J Cancer2003，106，：	1
8	Cadmium-induced renal dysfunction: new mechanismt treatment and prevention显示文摘	Kazuo N Hiroko N	1998	Trace Elements in Ex-perim Med1998，11，：	1
9	Molecular strategy for survival at a critical high temperature in Eschierichia coli显示文摘	Masayuki M Hiroko F KAORI N	2011	PLoS ONE2011，6，20：	1
10	Impact of CD44^+CD24^- cells on non-sentinel axillary lymph node metastases in sentinel node-positive breast cancer显示文摘	Hiroko N Masafumi S Makiko K	2011	Oncol Rep2011，25，4：	1
11	Properties of ricecooked with commercial water-soluble soybean polysaccha-rides extracted under weakly acidic conditions from soybeancotyledons 显示文摘	Hitoshi F Akihiro N Hiroko A	2003	Bioscience Biotechnology and Biochemis-try2003，67，4：	1
12	Protective responses against experimental mycobacterium lepra infection in mice induced by recombinant bacillus Calmette-Guerin over-producing three putative protective antigen candidates显示文摘	Naoya O Matsuoka H Hiroko N	2001	Vaccine2001，19，：	1
13	Correlation of reflux esophagitis and obesity: quantitative and qualitative analysis显示文摘	Kaoru N Hiroko H Akira T	2003	Jikeikai Med J2003，50，：	1
14	Molecular cloning and sequence analysis of an extraeellular protease from four Bacillus subtilb strains显示文摘	Hiroko N Han X J Yuh S	2013	Bioscience Biotechnology and Biochemistry2013，77，4：	1
15	Cadmium-induced renal dysfunction:New mechanism,treatment and prevention显示文摘	Kazuo N Hiroko N	1998	The Journal of Trace Elements in Experimental Medicine1998，11，23：	1
16	Reactivation of inactivated horseradish peroxidase with ethyleneurea and allantoin for determination of hydrogen peroxide by micro-flow injection horseradish peroxidase-catalyzed chemiluminescence显示文摘	Osamu N Hiroko K	2003	Anal Chim Acta2003，495，12：	1
17	Improvement of low cathodoluminescent reperties of zinc sulfide phosphors by sol/gel method 显示文摘	Hiroko K Takato N Yoichiro N	1996	Japanese Journal of Applied Physics1996，35，：	1
18	Lipepelysaccharide-in-duced IL-18 secretion from murine Kuppffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-β显示文摘	Ekihiro S Hiroko T Hiroki N	2001	J Immunol2001，166，：	1
19	Two triterpenoid glycosides from leaves ofIlex cornuta 显示文摘	Tsutomu N Hiroko T Masao N	1982	Phytochemistry1982，21，6：	1
20	Edaravone directly reacts with singlet oxygen and protects ce\|ls from attack 显示文摘	Yoko N Hiroko M Nobuyuki E	2010	Life Sci2010，86，：	1

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