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| 1 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 2 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 3 | Biodiesel fuel production with solid superacid catalysis in fixed bed reactor under atmospheric pressure显示文摘 | Satoshi F Hiromi M Kazushi A | 2004 | Catalysis Communications2004，5，12： | 1 |
| 4 | Effects of Microwave Heating on the Loss of Vitamin B12 in Foods显示文摘 | Fumio W Katsuo A Hiromi K | 1998 | Agricultural and Food Chemistry1998，46，： | 1 |
| 5 | PCR-based molecular markers in Asiatic hybrid lily显示文摘 | MASUMI Y HIROMI A MICHIHARU N | 2002 | Scientia Horticuhure2002，，96： | 1 |
| 6 | Biological Activity of Hydroxo-vitamin B12 Degradation Product Formed during Microwave Heating 显示文摘 | Fumio W Katsuo A Hiromi K | 1998 | Journal of Agricultural and Food Chemistry1998，46，： | 1 |
| 7 | Biodiesel Fuel Production with Solid Superacid Catalysis in Fixed Bed Reactor under Atmospheric Pressure显示文摘 | Satoshi F Hiromi M Kazushi A | 2004 | Catalysis Communications2004，5，12： | 1 |
| 8 | Biodiesel fuel production with solid amorphous-zirconia catalysis in fixed bed reactor显示文摘 | Satoshi F Hiromi M Kazushi A | 2006 | Biomass and Bioenergy2006，30，： | 1 |
| 9 | Local structures and photocatalytic reactivities of the titanium oxide and chromium oxide species incorporated within micro-and meso-porous zeolite materials:XAFS and photoluminescence studies显示文摘 | Hiromi Y Masakazu A 2003 | 2003 | Solid State Mater Sci2003，7，6： | 1 |
| 10 | Microstructural Characterization of High-Thermal-Con- ductivity Aluminum Nitride Ceramic显示文摘 | Hiromi Nakano Koji Watari Hiroyuki Hayashi et a | 2002 | Journal of the American Ceramic Society2002，85，12： | 1 |
| 11 | Biodiesel fuel production with solid amorphous-zirconia catalysis in fixed bed reactor显示文摘 | SATOSHI F HIROMI M KAZUSHI A | 2006 | Biomass and Bioenergy2006，，30： | 1 |
| 12 | Catalytic action of sulfated in oxide for etherification and etherification in comparison with sulfated zirconia显示文摘 | Satoshi F Hiromi M Kazushi A | | 0，，： | 1 |
| 13 | Biodiesel Fuel Production with Solid Superacid Catalysis in Fixed Bed Reactor under Atmospheric Pressure 显示文摘 | SATOSHI F HIROMI M KAZUSHI A | 2004 | Catalysis communications2004，5，12： | 1 |
| 14 | Catalyticaction of sulfatedtin oxide for etherification and esterification in comparison with sulfated zirconia显示文摘 | Satoshi F Hiromi M Kazushi A | 2004 | Applied Catalysis A:General2004，269，： | 1 |
| 15 | A novel magnetic suspension-force compensation in bearingless induction motor drive with squirrel-cage rotor 显示文摘 | HIROMI T KATOU T CHIBA A | 2007 | IEEE Transactions on Industry Applications2007，43，1： | 1 |
| 16 | Pharmaeokinctics of mirabegron, a 133-adrenoceptor agonist for treatment of overactive bladder, in healthy japanese male subjects:results from single-and multiple-dose studies 显示文摘 | HIROMI I TOMOAKI T YOKO A | 2013 | Clin Drug lnvestig2013，34，1： | 1 |
| 17 | Alkylation to form trimethyl-pentanes from isobutane and 1-butene catalyzed by solid superacids of sulfated metal oxides显示文摘 | Kunihiko S Hiromi M Kazushi A | 1999 | Appl Catal1999，189，： | 1 |
| 18 | Ihibition of Angiogenesis by Humulone,a Bitter Acid from Beer Hop显示文摘 | MARICAL S TADAHIKO H HIROMI A | 2001 | Biochemical and biophysical Research Communications2001，289，： | 1 |
| 19 | PCR-based molecular markers in Asiatic hybrid lily显示文摘 | Masumi Y Hiromi A Michiharu N | 2002 | Scientia Horticulturae2002，96，： | 1 |
| 20 | Catalytic action of sulfated tin oxide for etherifieation and esterifieation in comparison with sulfated zirconia 显示文摘 | Satoshi F Hiromi M Kazushi A | 2004 | Applied Catalysis A: General2004，269，： | 1 |
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