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| 1 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 2 | Colorectal cancer in the young,many questions,few answers显示文摘At a time where the incidence of colorectal cancer,a disease predominantly of developed nations,is showing a decline in those 50 years of age and older,data from the West is showing a rising incidence of this cancer in young individuals.Central to this has been the 75% increase in rectal cancer incidence in the last four decades.Furthermore,predictive data based on mathematical modelling indicates a 124 percent rise in the incidence of rectal cancer by the year 2030-a statistic that calls for collective global thought and action.While predominance of colorectal cancer(CRC) is likely to be in that part of the large bowel distal to the splenic flexure,which makes flexible sigmoidoscopic examination an ideal screening tool,the cost and benefit of mass screening in young people remain unknown.In countries where the incidence of young CRC is as high as 35% to 50%,the available data do not seem to indicate that the disease in young people is one of high red meat consuming nations only.Improvement in our understanding of genetic pathways in the aetiology of CRC,chiefly of the MSI,CIN and CIMP pathway,supports the notion that up to 30% of CRC is genetic,and may reflect a familial trait or environmentally induced changes.However,a number of other germline and somatic mutations,some of which remain unidentified,may play a role in the genesis of this cancer and stand in the way of a clear understanding of CRC in the young.Clinically,a proportion of young persons with CRC die early after curative surgery,presumably from aggressive tumour biology,compared with the majority in whom survival after operation will remain unchanged for five years or greater.The challenge in the future will be to determine,by genetic fingerprinting or otherwise,those at risk of developing CRC and the determinants of survival in those who develop CRC.Ultimately,prevention and early detection,just like for those over 50 years with CRC,will determine the outcome of CRC in young persons.At present,aside from those with an established familial tendency,there is no consensus on screening young persons who may be at risk.However,increasing awareness of this cancer in the young and the established benefit of prevention in older persons,must be a message that should be communicated with medical students,primary health care personnel and first contact doctors.The latter constitutes a formidable challenge. | Kemal I Deen Hiroshi Silva Raeed Deen Pramodh C Chandrasinghe | 2016 | World Journal of Gastrointestinal Oncology2016，8，6： | 2 |
| 3 | Sintering characteristics in the BaTiO3-Nb2O5-Co3O4 ternary system I,electric properties and microstructure显示文摘 | HIROKAZU C HIROSHI K | | 0，，10： | 1 |
| 4 | Fatty acid composition of five candidate aquaculture species in Central Philippines 显示文摘 | Ogata Hiroshi Y Emata Amil C Garibay Esteban S | 2004 | Aquacultre2004，236，： | 1 |
| 5 | Characteristics in the BaTiO3-Nb2O5-Co3O4 ternary system Ⅱ,stability of so-called 'core-shell' structure显示文摘 | HIROKAZU C HIROSHI K | | 0，，： | 1 |
| 6 | Advanced Concepts in Electric Vehicle Design 显示文摘 | Hiroshi Shimizu Junji Harada Bland C | 1997 | IEEE Trans Ind Electron1997，44，1： | 1 |
| 7 | Biochemical characterization and expression of recombinant ACC oxidase in Escherichia coli and endogenous ACC oxidase from kiwifruit显示文摘 | ZHONG C X HIROSHI H YOSHINORI I | 1998 | Postharvest Biology and Technology1998，14，： | 1 |
| 8 | Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor显示文摘 | Hiroshi M Wu D C Daniel K | 1996 | Science1996，274，5285： | 1 |
| 9 | 查看详情显示文摘 | Sun Y Noel C Hiroshi K Biwu M Thompson M E Forrest S R | | 0，，： | 1 |
| 10 | Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E 2 and selective prostaglandin receptor agonists in murine osteoblastic cells显示文摘 | Yoko Sakuma Ziaodong Li Carol C Pilbeam Cynthia B Alander Daichi Chikazu Hiroshi Kawaguchi Lawrence G Raisz | 2003 | Bone2003，，5： | 1 |
| 11 | Microbial alkaline protease: From a bioindustrial viewpoint 显示文摘 | Ganesh Kumar C Takagi Hiroshi | 1999 | Biotechnology Advanced1999，17，： | 1 |
| 12 | Base - Metal Electrode - Multilayer Ceramic Capacitors: Past, Present and Future Perspectives 显示文摘 | Hiroshi K Youichi M Hirokazu C | 2003 | Japanese journal of applied physics2003，42，： | 1 |
| 13 | On-orbit atti tude control experiments using ETS-VI by control and two-degree-of-freedom control 显示文摘 | Yuichi C Hiroshi S Yoshitake Y | 1998 | Control Engineer- ing Practice1998，6，： | 1 |
| 14 | Omni-directional image-based modeling: three approaches to approximated plenoptic representations 显示文摘 | Hiroshi Ishiguro Kim C Ng Richard Capella | 2003 | Machine Vision and Applications(S0932-8092)2003，14，2： | 1 |
| 15 | Biotransformation of (±)-α-ionone and β-ionone by cultured cells ofCaragana chamlagu 显示文摘 | HIROSHI S KEN-ICHI I WEN C | 2004 | J Mole Catal B: Enzymatic2004，27，： | 1 |
| 16 | Hemin-induced activation of the thioredoxin gene by Nrf2 显示文摘 | YONG C K HIROSHI M YOSHIMI Y | 2001 | J Biol Chem2001，276，18： | 1 |
| 17 | Sintering characteris-tics in BaTiO3-Nb2O5-Co3O4ternary system:I,elec-trical properties and microstructure显示文摘 | HIROKAZU C HIROSHI K | 1999 | Am CeramSoc1999，82，10： | 1 |
| 18 | Battery per- formances and thermal stability of polyacrylonitrile nano-fi- ber-based nonwoven separators for Li-ion battery, Journal of Power Sources显示文摘 | Tae H C Masanao T Hiroshi O | 2008 | 181: 155-1602008，181，： | 1 |
| 19 | How does the mitochondrial ADP/ATP carrier distinguish transportable ATP and ADP from untransportable AMP and GTP? Dynamic modeling of the recognition/ translocation process in the major substrate binding region显示文摘 | Satoru G Hiroshi C Eiji M | 2002 | Biochim Biophys Acta2002，1589，23： | 1 |
| 20 | Sintering characteris-tics in BaTiO3-Nb2O5-Co3O4ternary system:Ⅱ,sta-bility of so-called“core-shel”structure显示文摘 | HIROKAZU C HIROSHI K | 2000 | Am CeramSoc2000，83，1： | 1 |
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