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| 1 | Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus显示文摘AIM:To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE).METHODS:Electronic pathology database established in the Department of Pathology of the Nanjing Drum Tower Hospital was searched for consecutive resection cases of proximal gastric carcinoma over the period from May 2004 through July 2009.Each retrieved pathology report was reviewed and the cases with tumors crossing the gastroesophageal junction line were selected as PGCE.Each tumor was re-staged,following the guidelines on esophageal adenocarcinoma,according to the 7th edition of the American Joint Commission on Cancer Staging Manual.All histology slides were studied along with the pathology report for a retrospective analysis of 13 clinicopathologic features,i.e.,age,gender,Helicobacter pylori (H.pylori ) infection,surgical modality,Siewert type,tumor Bormann's type,size,differentiation,histology type,surgical margin,lymphovascular and perineural invasion,and pathologic stage in relation to survival after surgical resection.Prognostic factors for overall survival were assessed with uniand multi-variate analyses.RESULTS:Patients' mean age was 65 years (range:47-90 years).The male:female ratio was 3.3.The 1-,3and 5-year overall survival rates were 87%,61% and 32%,respectively.By univariate analysis,age,male gender,H.pylori ,tumor Bormann's type,size,histology type,surgical modality,positive surgical margin,lymphovascular invasion,and pT stage were not predictive for overall survival;in contrast,perineural invasion (P = 0.003),poor differentiation (P = 0.0003),> 15 total lymph nodes retrieved (P = 0.008),positive lymph nodes (P = 0.001),and distant metastasis (P = 0.005) predicted poor post-operative overall survival.Celiac axis nodal metastasis was associated with significantly worse overall survival (P = 0.007).By multivariate analysis,≥ 16 positive nodes (P = 0.018),lymph node ratio > 0.2 (P = 0.003),and overall pathologic stage (P = 0.002) were independent predictors for poor overall survival after resection.CONCLUSION:Patients with PGCE showed worse overall survival in elderly,high nodal burden and advanced pathologic stage.This cancer may be more accurately staged as gastric,than esophageal,cancer. | Yi-Fen Zhang Jiong Shi Hui-Ping Yu An-Ning Feng Xiang-Shan Fan Gregory Y Lauwers Hiroshi Mashimo Jason S Gold Gang Chen Qin Huang | 2012 | World Journal of Gastroenterology2012，18，27： | 12 |
| 2 | Endoscopic management of chronic radiation proctitis显示文摘Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously,some lead to chronic symptoms including diarrhea,tenesmus,urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiation proctitis remain unsatisfactory and the basis of evidence for various therapies is generally insuff icient. There are very few controlled or prospective trials,and comparisons between therapies are limited because of different evaluation methods. Medical treatments,including formalin,topical sucralfate,5-amino salicylic acid enemas,and short chain fatty acids have been used with limited success.Surgical management is associated with high morbidity and mortality. Endoscopic therapy using modalities such as the heater probe,neodymium:yttrium-aluminium-garnet laser,potassium titanyl phosphate laser and bipolar electrocoagulation has been reported to be of some benef it,but with frequent complications.Argon plasma coagulation is touted to be the preferred endoscopic therapy due to its eff icacy and safety profile.Newer methods of endoscopic ablation such as radiofrequency ablation and cryotherapy have been recently described which may afford broader areas of treatment per application,with lower rate of complications.This review will focus on endoscopic ablation therapies,including such newer modalities,for chronic radiation proctitis. | Tarun Rustagi Hiroshi Mashimo | 2011 | World Journal of Gastroenterology2011，17，41： | 8 |
| 3 | Cervical inlet patch-optical coherence tomography imaging and clinical significance显示文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP. | Chao Zhou Tejas Kirtane Tsung-Han Tsai Hsiang-Chieh Lee Desmond C Adler Joseph M Schmitt Qin Huang James G Fujimoto Hiroshi Mashimo | 2012 | World Journal of Gastroenterology2012，18，20： | 3 |
| 4 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 5 | Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)显示文摘 | Chao Zhou Tsung-Han Tsai Hsiang-Chieh Lee Tejas Kirtane Marisa Figueiredo Yuankai K. Tao Osman O. Ahsen Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 6 | Sa1611 Treatment of Chronic Radiation Proctopathy With Radiofrequency Ablation显示文摘 | Tarun Rustagi F Scott Corbett Hiroshi Mashimo | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 7 | Endotherapy for and tailored approaches to treating GERD, and refractory GERD显示文摘 | G. Richard Locke John Horwhat Hiroshi Mashimo Edoardo Savarino Patrizia Zentilin Vincenzo Savarino Frank Zerbib Steven P. Armbruster Roy K. Wong Fouad Moawad | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 8 | Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor显示文摘 | Hiroshi Mashimo Deng-Chyang Wu Daniel K | 1996 | Science1996，274，： | 1 |
| 9 | Effects of Crystalloid and Colloid Preload on Blood Volume in the Parturient Undergoing Spinal Anesthesia for Elective Cesarean Section显示文摘 | Hiroshi Ueyama Yan-Ling He Hironobu Tanigami Takashi Mashimo Ikuto Yoshiya | 1999 | Anesthesiology1999，，6： | 1 |
| 10 | Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines <ce:link locator='fx1'/>显示文摘 | Pei-Lin Hsiung Liron Pantanowitz Aaron D. Aguirre Yu Chen Darshan Phatak Tony H. Ko Stephane Bourquin Stuart J. Schnitt Sugrah Raza James L. Connolly Hiroshi Mashimo James G. Fujimoto | 2005 | Gastrointestinal Endoscopy2005，，4： | 1 |
| 11 | Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos)显示文摘 | Chao Zhou Tsung-Han Tsai Hsiang-Chieh Lee Tejas Kirtane Marisa Figueiredo Yuankai K. Tao Osman O. Ahsen Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo | 2012 | Gastrointestinal Endoscopy2012，，1： | 1 |
| 12 | Subsquamous intestinal metaplasia after ablation of Barrett?s esophagus: frequency and importance显示文摘 | Hiroshi Mashimo | 2013 | Current Opinion in Gastroenterology2013，，4： | 1 |
| 13 | Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett’s esophagus radiofrequency ablation treatment response (with videos)显示文摘 | Tsung-Han Tsai Chao Zhou Yuankai K. Tao Hsiang-Chieh Lee Osman O. Ahsen Marisa Figueiredo Tejas Kirtane Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 14 | Subsquamous intestinal metaplasia after ablation of Barrett?s esophagus: frequency and importance显示文摘 | Hiroshi Mashimo | 2013 | Current Opinion in Gastroenterology2013，，4： | 1 |
| 15 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 1 |
| 16 | Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett’s esophagus radiofrequency ablation treatment response (with videos)显示文摘 | Tsung-Han Tsai Chao Zhou Yuankai K. Tao Hsiang-Chieh Lee Osman O. Ahsen Marisa Figueiredo Tejas Kirtane Desmond C. Adler Joseph M. Schmitt Qin Huang James G. Fujimoto Hiroshi Mashimo | 2012 | Gastrointestinal Endoscopy2012，，6： | 1 |
| 17 | Extraction equilibium of aluminum and beryllium from sulfate media by mixture ofbis (2- ethylhexyl) phosphoric acid and dinonylnaphthalene sulfonic acid 显示文摘 | Miki Mashimo Hiroshi Sato Makoto Uedo | 1997 | Chem Eng Jpn1997，30，4： | 1 |
| 18 | Treatment of chronic radiation proctopathy with radiofrequency ablation显示文摘 | Tarun Rustagi F. Scott Corbett Hiroshi Mashimo | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 19 | Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare显示文摘 | Qin Huang Jiong Shi Qi Sun Xiangshan Fan Anning Feng Hongyan Wu Qiang Zhou Chenggong Yu Hiroshi Mashimo Gregory Y. Lauwers | 2012 | Human Pathology2012，，12： | 1 |
| 20 | Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study显示文摘BACKGROUND Chronic radiation proctopathy(CRP) occurs as a result of pelvic radiation therapy and is associated with formation of abnormal vasculature that may lead to persistent rectal bleeding. While incidence is declining due to refinement of radiation delivery techniques, CRP remains one of the major complications of pelvic radiation therapy and significantly affects patient quality of life.Radiofrequency ablation(RFA) is an emerging treatment modality for eradicating abnormal vasculature associated with CRP. However, questions remain regarding CRP pathophysiology and optimal disease management.AIM To study feasibility of optical coherence tomography angiography(OCTA) for investigating subsurface vascular alterations in CRP and response to RFA treatment.METHODS Two patients with normal rectum and 8 patients referred for, or undergoing endoscopic RFA treatment for CRP were imaged with a prototype ultrahighspeed optical coherence tomography(OCT) system over 15 OCT/colonoscopy visits(2 normal patients, 5 RFA-na?ve patients, 8 RFA-follow-up visits). OCT and OCTA was performed by placing the OCT catheter onto the dentate line and rectum without endoscopic guidance. OCTA enabled depth-resolved microvasculature imaging using motion contrast from flowing blood, withoutrequiring injected dyes. OCTA features of normal and abnormal microvasculature were assessed in the mucosa and submucosa. Blinded reading of OCTA images was performed to assess the association of abnormal rectal microvasculature with CRP and RFA treatment, and rectal telangiectasia density endoscopic scoring.RESULTS OCTA/OCT images are intrinsically co-registered and enabled depth-resolved visualization of microvasculature in the mucosa and submucosa. OCTA visualized normal vascular patterns with regular honeycomb patterns vs abnormal vasculature with distorted honeycomb patterns and ectatic/tortuous microvasculature in the rectal mucosa. Normal arterioles and venules < 200 μm in diameter versus abnormal heterogenous enlarged arterioles and venules > 200μm in diameter were visualized in the rectal submucosa. Abnormal mucosal vasculature occurred in 0 of 2 normal patients and 3 of 5 RFA-na?ve patients,while abnormal submucosal vasculature occurred more often, in 1 of 2 normal patients and 5 of 5 RFA-na?ve patients. After RFA treatment, vascular abnormalities decreased, with abnormal mucosal vasculature observed in 0 of 8 RFA-follow-up visits and abnormal submucosal vasculature observed in only and 2 of 8 RFA-follow-up visits.CONCLUSION OCTA visualizes depth-resolved microvascular abnormalities in CRP, allowing assessment of superficial features which are endoscopically visible as well as deeper vasculature which cannot be seen endoscopically. OCTA/OCT of the rectum can be performed in conjunction with, or independently from endoscopy.Further studies are warranted to investigate if OCTA/OCT can elucidate pathophysiology of CRP or improve management. | Osman Oguz Ahsen Kaicheng Liang Hsiang-Chieh Lee Zhao Wang James G Fujimoto Hiroshi Mashimo | 2019 | World Journal of Gastroenterology2019，25，16： | 0 |
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