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| 1 | Bleb needling outcomes for failed trabeculectomy blebs in Asian eyes: a 2-year follow up显示文摘·AIM: To describe the outcomes of bleb needling in primary glaucoma in an Asian tertiary eye centre over a2 y period. To compare the success rates between primary angle-closure glaucoma(PACG) and primary open angle glaucoma(POAG). Lastly, to identify factors associated with success of bleb needling.·METHODS: This was a retrospective review of 227 patients who underwent bleb needling between June2009 and June 2011 in Singapore National Eye Centre.The 5-fluorouracil(5-FU) augmented bleb needling was performed either at the slit lamp or in the operating theatre. Repeat bleb needlings were performed as necessary. Complete success was defined as maintenance of intraocular pressure(IOP) ≥6 mm Hg and ≤21 mm Hg, in the absence of further surgery or use of antiglaucoma medication. Qualified success met the above criteria with or without use of antiglaucoma medications.· RESULTS: One hundred and seventy-five eyes completed the two-year follow up. Sixty-nine percent of participants had POAG and 31% had PACG. The mean interval between filtering surgery and bleb needling was299.9 ±616.4d for POAG and 167.1 ±272.2d for PACG.Mean needling attempts were 1.9±1.4 and 2±1.6 for POAG and PACG respectively. In general, there was a statistically significant reduction of IOP ranging from21.9% to 26.8% from month 1 through to month 24. The complete success rates at month 6 were 70.0% for POAG and 65.7% for PACG. At month 12, this decreased to62.2% for POAG and PACG and at month 24, 57.9% for POAG and 63.0% for PACG respectively. The qualified success rates at month 6 for POAG and PACG were23.8% and 29.9% respectively, 32.2% and 29.2% at month12, and 34.7% and 29.6% at month 24. The success ratesbetween POAG and PACG were not significantly different(P >0.05 for complete and qualified success at months 6,12 and 24). An increased number of needlings and higher pre-needling IOP were associated with failure.·CONCLUSION: The 5-FU augmented bleb needling within one year of trabeculectomy in Asian eyes can provide clinically significant IOP lowering of more than20% for 2y. POAG and PACG had similar complete success rates(58% and 63% respectively). Factors associated with greater risk of procedure failure included increased number of needlings and higher pre-needling IOP. Asian eyes have a greater propensity for scarring but bleb needling, if performed in a timely manner can rescue bleb function. | Andrew S.H.Tsai Pui Yi Boey Hla M Htoon Tina T Wong | 2015 | International Journal of Ophthalmology(English edition)2015,8,4: | 2 |
| 2 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Inee C | 2006 | Anesth Analg2006,103,2: | 1 |
| 3 | Orthogonal polarization spectral imaging of the microcirculation during acute hypervolemic hemodilution and epidural lidocaine injection显示文摘 | Van den Oever HLA Dzoljic M Ince C | 2006 | Anesth Analg2006,2,: | 1 |
| 4 | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(1) , G(q) , and G(12) families of heterotrimeric G pro- teins显示文摘 | Windh RT Lee M J Hla T | 1999 | J Biol Chem1999,274,27: | 1 |
| 5 | Lysophospholipids-receptor revelations 显示文摘 | Hla T Lee M J Ancellin N | 2001 | Science2001,294,: | 1 |
| 6 | Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish显示文摘 | Lam S H Hlaing M M Zhang X | 2011 | PLoSOne2011,6,28: | 1 |
| 7 | Pegylated interferon alfa -2 b alone or incombination with la- mivudine for HBeAg-positive chronic hepatitis B: a randomized trial 显示文摘 | Janssen HLA Van Zonnveld M Senturk H | 2005 | Lancet2005,365,: | 1 |
| 8 | longitudinal association of sleep-related breathing disorder and depression显示文摘 | Peppard P E Szklo-Coxe M Hla K M | 2006 | Arch Intern Med2006,166,16: | 1 |
| 9 | Sleep apnea and quality of life显示文摘 | Yang E H Hla K M McHomey C A | 2000 | Sleep2000,23,4: | 1 |
| 10 | Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibi- tion 显示文摘 | SIMMONS D L BOtTING R M HLA T | 2004 | Pharmacological Reviews2004,56,3: | 1 |
| 11 | A new ranging method for OFDMA systems 显示文摘 | FU X Y LI Y H HLAING M | 2007 | IEEE Transactions on Wireless Communications2007,6,2: | 1 |
| 12 | In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarihritis and rats with adjuvant and streptococcal cell wall arthritis显示文摘 | Sano H Hla T Maier J A M | | 0,,: | 1 |
| 13 | Sleep apnea and quality of life显示文摘 | Yang E H Hla K M McHomey C A | 2000 | Sleep2000,1523,4: | 1 |
| 14 | Pilot designs for channel estimation of MIMO OFDM systems with frequency-dependent I/Q imbalances显示文摘 | Hlaing M Munoz D | 2010 | IEEE Transactions on Communications2010,58,8: | 1 |
| 15 | Sleep apnea and hyperten - sion, a pop- ulation - based study显示文摘 | HLA K M YOUNG T B | 1994 | Ann Intern Med1994,120,3: | 1 |
| 16 | Toxicogenomic and phenotypic analyses of bisphenol-A early-life ex- posure toxicity in zebrafish 显示文摘 | Lam S H Hlaing M M Zhang X | 2011 | Plos One2011,6,28: | 1 |
| 17 | A Combined Timing and Frequency Synchronization and Channel Estimation for OFDM显示文摘 | HLAING M BHARGAVA V K LETAIEF K B | 2006 | IEEE Transactions on Communications2006,54,3: | 1 |
| 18 | PIC-based iterative SDR detector for OFDM systems in doubly-selective fading channels显示文摘 | SHU Feng HLAING M LIANG Yan LU Jinhui | 2010 | IEEE Transactions on Wireless Communications2010,9,1: | 1 |
| 19 | Modelling and control of multivariable processes using generalized Hammerstein model显示文摘 | Hlaing Y M Chiu M S Lakshminarayanan S | 2007 | Chemical Engineering Research and Design2007,85,4: | 1 |
| 20 | Signaling of sphingosine-1-phosphate via the S1P/EDG- family of G- protein- coupled receptors 显示文摘 | KLUK M J HLA T | 2002 | Biochim Biophys Acta2002,1582,13: | 1 |