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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 3 | Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during 2001 winter period 显示文摘 | CAO J J LEE S C HO K F | 2003 | Atmos Environ2003，37，： | 1 |
| 4 | Sophisticated experience-Weighted attraction learning and strategic teaching in repeated games显示文摘 | Ho T-H Chong J-K | 2002 | Journal of Economic Theory2002，104，： | 1 |
| 5 | Recovery of municipa waste incineration bottom ash and water treatmen sludge to water permeable pavement materials 显示文摘 | LIN C F WU C H HO H M | 2006 | Waste Management2006，26，9： | 1 |
| 6 | Excentral cleavage of beta- carotene in vivo in a healthy man显示文摘 | HO C C de MOURA F F KIM S H | 2007 | Clin Nutr2007，85，3： | 1 |
| 7 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 8 | Positive sampling artifacts in particulate organic carbon measurements in roadside environment显示文摘 | CHENG Y LEE S C HO K F | 2010 | Environmental Monitoring and Assessment2010，168，1234： | 1 |
| 9 | Integration of nitrogen and potassium signaling显示文摘 | Tsay Y F Ho C H Chen H Y | 2011 | Annual Review of Plant Biology2011，62，4： | 1 |
| 10 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 11 | Detection and tissue tropism of white spot syndrome baculuvirus(WSBV) in captured brooders of Penaeus monodon with a special emphasis on reproductive organs 显示文摘 | Lo C F Ho C H Chen C H | 1997 | Dis Aquat Org1997，30，： | 1 |
| 12 | Micro-Doppler Effect in Radar-Phenomenon,Model and Simulation Study显示文摘 | Chen V C Li F Y Ho S S | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，1： | 1 |
| 13 | Models of thinking,learning and teaching games显示文摘 | Teck-Hua Ho Juin-Kuan Chong | 2003 | The American Economic Review2003，93，2： | 1 |
| 14 | Micro-doppler effect in radar:phenomenon,model,and simulation study显示文摘 | Chen V C Li F Y Ho S | 2006 | IEEE Transactionson Aerospace and Electronic Systems2006，42，1： | 1 |
| 15 | Effects of Asian dust e- vents on daily hospital admissions for chronic obstructive pul- monary disease in Taipei, Taiwan显示文摘 | Chiu H F Tiao M M Ho S C | 2008 | Inhalation Toxicology2008，20，： | 1 |
| 16 | High glucose-induced apopto- sis in human vascular endothelial ceils is mediated through NF- kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway显示文摘 | Ho F M Lin W W Chen B C | 2006 | Cell Signal2006，18，3： | 1 |
| 17 | A Cognitive hierarchy model of games显示文摘 | Teck-Hua Ho Juin-Kuan Chong | 2004 | Quarterly Journal of Economics2004，119，3： | 1 |
| 18 | Carbonaceous characteristics of atmospheric particulate matter in Hong Kong显示文摘 | HO K F LEE S C YU J M C | 2002 | The Science of the Total Environment2002，300，： | 1 |
| 19 | Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line显示文摘 | Liu W K Ho J C Cheung F W | 2004 | Eur J Pharmacol2004，498，13： | 1 |
| 20 | Structure and properties of cast binary Ti-Mo alloys 显示文摘 | HO W F JU C P CHERN-LIN J H | 1999 | Biomaterials1999，20，： | 1 |
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