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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Engineering hybrid genes without the use of restriction enzymesgene splicing by overlap extension显示文摘 | HORTON R M HUNT H D HO S N | 1989 | Gene1989，77，1： | 1 |
| 3 | Site directed mutagenesis by over lap extension using the polymerase chain reaction 显示文摘 | Ho S N Hunt H D Horton R N | 1989 | Gene1989，77，： | 1 |
| 4 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 5 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 6 | Nonbasal deformation modes of HCP metals and alloys: Role of dislocation source and mobility显示文摘 | Yoo M H Morris J R Ho K M | 2002 | Metall Mater Trans2002，33，： | 1 |
| 7 | The components of the bid-ask spread in a limit-order market: evidence from the Tokyo Stock Exchange显示文摘 | Ahn H J Cai J Hamao Ho R Y K | 2002 | Journal of Empirical Finance2002，9，4： | 1 |
| 8 | Mango malformation disease in South China caused by Fus arium p roliferotum显示文摘 | ZHAN R L YANG S J HO H H LIU F ZHAO Y L CHANG J M HE Y B | 2010 | Journal of Phytopathology2010，158，： | 1 |
| 9 | Site-directed mutgenesis by overlap extension using, the polymerase chain reaction 显示文摘 | Ho S N Hunt H D Horton R M | 1989 | Gene1989，，77： | 1 |
| 10 | An epidemic of enterovims 71 infection in Taiwan显示文摘 | HO M CHEN E R HSU H | 1999 | N Engl J Med1999，341，13： | 1 |
| 11 | Dietary HDAC inhibitors : time to rethink weak ligands in cancer chemoprevention? 显示文摘 | DASHWOOD R H MYZAK M C Ho E | 2006 | Carcinogenesis2006，27，2： | 1 |
| 12 | Incentive Mechanisms,Fairness and Participation in Online Group-buy Auction显示文摘 | Kauffman R J Lai H Ho C T | 2010 | Electronic Commerce Research and Applications2010，15，9： | 1 |
| 13 | Engineering hy- brigenes without the use of restriction enzymes: gene splicing by overlap extension 显示文摘 | Horton R M Hunt H D Ho S N | 1989 | Gene1989，，77： | 1 |
| 14 | Site-directed Mutagenesis by Overlap Extension Using the Polymerase Chain Reaction 显示文摘 | HO S N HUNT H D HORTON R M | 1989 | Gene1989，77，1： | 1 |
| 15 | Salt and pepper noise removal by median type noise detectors and detail preserving regularization显示文摘 | Chan R H Ho C W Nikolova M | 2005 | IEEE Trans Image Processing2005，14，10： | 1 |
| 16 | In vivo dynamics of T cell activation,proliferation,and death in HIV-1 infection:why are CD4+ but not CD8^+T cells depleted显示文摘 | Ribeiro R M Mohri H Ho DD | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 17 | Salt-and-pepper noise removal by median-type noise detectors and detail-preserving regularization显示文摘 | Chan R H Ho C W Nikolova M | 2005 | IEEE Transactions on Image Processing2005，14，10： | 1 |
| 18 | Optomal production run length for products with warranty显示文摘 | Ho Wen-Tsung Tseng Sheng-Tsaing | 2000 | European Journal of Operation Research2000，120，： | 1 |
| 19 | State of the art in wire electrical discharge machining (WEDM) 显示文摘 | HO K H NEWMAN S T RAHIMIFARD S ALLEN R D | 2004 | International Journal of Machine Tools & Manufacture2004，44，： | 1 |
| 20 | Life cycle assessment study of solar PV systems:an example of a 27 kWp distributed solar PV system in Singapore显示文摘 | Kannan R Leong K C Osman R Ho H K Tso C P | | 0，，05： | 1 |
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