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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 3 | Infection of primary human fetal astrocytes by human herpesvirus 6 显示文摘 | He JM Zhou Y Chandran B | 1996 | Virology1996，70，： | 2 |
| 4 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 5 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 6 | MCPSO: a multi-swarm cooperative particle swarm optimizer显示文摘 | Niu B Zhu Y He X | 2007 | Applied Mathematics and Computation2007，185，2： | 1 |
| 7 | Electrodeposition of Pt-Ru nanoparticles on carbon nanotubes and their electrocatalytic properties for methanol electrooxidation 显示文摘 | He Z B Chen J H Liu D Y | 2004 | Diamond and Related Materials2004，13，10： | 1 |
| 8 | Self-Assembly of Block Copolymer Micelles in an Ionic Liquid显示文摘 | He Y Y Li Z B Simone P | 2006 | J Am Chem Soc2006，128，8： | 1 |
| 9 | Characterizations Of General Esterases in Relation to Malathion Susceptibility in Two Field Populations of the Oriental Migratory Locust, Locusta migratoria manilensis ( Meyen)显示文摘 | HE Y P MA E B ZHU K Y | 2004 | Pesticide Biochemistry and Physiology2004，78，： | 1 |
| 10 | Low-temperature exfoliated graphenes: vacuum-promoted exfoliation and electrochemical energy storage显示文摘 | Lv W Tang D M He Y B | 2009 | ACS Nano2009，3，11： | 1 |
| 11 | Carbohydrates from Cynanchum otophyllum 显示文摘 | Zhao Y B Shen Y M He H P | 2004 | Carbohydrate Research2004，339，11： | 1 |
| 12 | Host - parasite relation- ships of Schistosoma japonicum in mammalian hosts 显示文摘 | HE Y X SALAFSKY B RAMASWAMY K | 2001 | Trends Par- asitol2001，17，： | 1 |
| 13 | Effect of food on the pharmacokinetics of a vildagliptin/metfor rain (50/1 000 rag) fixed-dose combination tablet in healthy volunteers 显示文摘 | HE Y L FLANNERY B CAMPESTRINI J | 2008 | Curr Med Res Opin2008，24，6： | 1 |
| 14 | Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China显示文摘 | HE B Y DAI M H ZHAI W D | 2010 | Marine Chemistry2010，119，14： | 1 |
| 15 | Mechanism and experimental verification of degradation of RC beams induced by concrete/rebar Engineering Materials, 2011 bonding failure显示文摘 | He X B Huang F Zhang C Y | 2011 | Key2011，，： | 1 |
| 16 | Age and dura tion of the Emeishan flood volcanism, SW China: Geochemistry and SHRIMP zircon U-Pb dating of silicic ignimbrites, post-volcanic Xuanwei Formation and clay tuff at the Chaotian section显示文摘 | He B Xu Y G Huang L X | 2007 | Earth and Planetary Science Letters2007，255，： | 1 |
| 17 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 18 | Compliant needle modeling and steerable insertion simulation 显示文摘 | Tang L B Chen Y H He X J | 2008 | Computer-Aided Design and Applications2008，5，1234： | 1 |
| 19 | Determination of Sudan Dye Residues in Eggs by Liquid Chromatography and Gas Chromatography mass Spectrometry显示文摘 | He L Su Y Fang B | 2007 | Anal Chim Acta2007，594，1： | 1 |
| 20 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
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