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	题名	作者	年代	出处	被引量
1	Interleukin-6: a villain in the drama of pancreatic cancer development and progression显示文摘BACKGROUND: Pancreatic ductal adenocarcinoma(PDAC)is a devastating malignancy with a poor prognosis and little treatment options. The development and progression of the disease is fostered by inflammatory cells and cytokines. One of these cytokines is interleukin-6(IL-6), which plays an important role in a wide range of biologic activities.DATA SOURCES: A systematic search of PubMed was performed to identify relevant studies using key words such as interleukin-6,inflammatory cytokines, inflammation and pancreatic cancer or PDAC. Articles related to IL-6 and pancreatic cancer were systematically reviewed.RESULTS: IL-6 is elevated in the serum of pancreatic cancer patients and correlates with cachexia, advanced tumor stage and poor survival. Its expression is enhanced by hypoxia and proteins involved in pancreatic cancer development like Kras,mesothelin or ZIP4. IL-6 in turn contributes to the generation of a pro-tumorigenic microenvironment and is probably involved in angiogenesis and metastasis. In experimental mouse models of PDAC, IL-6 was important for the development and progression of precursor lesions.CONCLUSION: IL-6 emerges as a key player in pancreatic cancer development and progression, and hence should be considered as a new therapeutic target.	Reinhild Holmer Freya A Goumas Georg H Waetzig Stefan Rose-John Holger Kalthoff	2014	Hepatobiliary & Pancreatic Diseases International2014，13，4：	16
2	RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘	Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger	2016	Cell Research2016，26，7：	3
3	Genetic algorithms for reliability-based optimization of water distribution systems显示文摘	Bryan A Tolson Holger R Maierl Angus R Simpson	2005	Journal of Water Resources and Management2005，26，6：	1
4	Sulfated zirconia nanoparticles synthesized in reverse microemulsion: preparation and catalytic propertise 显示文摘	HOLGER A STEFAN K	2002	Langmuir2002，18，20：	1
5	Soft tissue reactions around percutaneous implants:a clinical study on skin- penetrating titanium implants used for bone-an-chored auricubr prostheses 显示文摘	Holgers KM Tjellstrom A Biursten LM	1985	Int J Oral Maxillofac Implants1985，2，：	1
6	Strategic Entrepreneurship at Universities: Academic Entrepreneurs' Assess ment of Policy Programs显示文摘	HOLGER P DEAN A S	2009	Entrepreneurship Theo- ry and Practice2009，33，1：	1
7	Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates显示文摘	Gassner Holger G Sherris David A	2000	Plast Reconstr Surg2000，105，6：	1
8	Genetic algorithms for reliability2based optimization of waterdistribution systems 显示文摘	Bryan A Tolson Holger R Maierl Angus R Simp son	2004	Journal of Water Resources andM anagem ent2004，，：	1
9	Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy 显示文摘	Holger A Scheidt	2004	Biochimica et Biophysica Acta2004，1663，：	1
10	Determination of secondary, di--iso-- nonylphthalate (DINP) metabolites in human urine representative for the exposure DINP plasticizers 显示文摘	M K Holger M Johannes A Jurgen	2006	Journal of Chromatography B2006，09，044：	1
11	Preparation of Luminescent ZnS: Cu Nanoparticles for the Functionalization of Transparent Acrylate Polymers 显示文摘	Andrea K Holger A Christian S	2010	Journal of Luminescence2010，130，4：	1
12	Botulinum toxin to minimize facial scarring显示文摘	David A Sherris M Holger G		0，，01：	1
13	mRNA expression and localization of bNOS,eNOS and iNOS in human cervix at preterm and term labour显示文摘	Susanne A T Holger M Aurelija K	2005	Reprod Biol Endocrinol2005，，3：	1
14	Elimina- tion of selection markers from transgenic plants 显示文摘	BARBARA H AVRAHAM A L HOLGER P	2001	Current Opinion in Biotechnology2001，12，2：	1
15	Linear-dendritic nonionic poly(propylene oxide)-polyglycerol surfactants显示文摘	VLADISLAV I HOLGER K YONG-KEUN K et a/	2003	Tetrahedr-on2003，59，：	1
16	The SSN ontology of the W3C semantic sensor network incubator group显示文摘	Michael Compton Payam Barnaghi Luis Bermudez Raúl García-Castro Oscar Corcho Simon Cox John Graybeal Manfred Hauswirth Cory Henson Arthur Herzog Vincent Huang Krzysztof Janowicz W. David Kelsey Danh Le Phuoc Laurent Lefort Myriam Leggieri Holger Neuhaus A	2012	Web Semantics: Science Services and Agents on the World Wide Web2012，，：	1
17	Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusaritvn oxysporum 显示文摘	PETRA E KLAUS A HOLGER B	1997	The Plant Cell1997，，9：	1
18	Polymer microfluidic devices显示文摘	Holger B A Laurie E L	2002	Talanta2002，56，：	1
19	Development and validation of a time-lag correction for vaisala radiosonde humidity Measurements显示文摘	Miloshevich L M Paukkunen A Holger Vomel H	2004	Journal of Atmospheric and Oceanic Technology2004，21，9：	1
20	miRNA regulation of Sdfl chemokine signaling provides genetic robustness to germ cell migration 显示文摘	Staton A A Holger K Giraldez A J	2011	Nature Genetics2011，43，3：	1

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