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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 与久坐者相比,职业运动员的肠道菌群在代谢组分,尤其是功能代谢水平上有所不同显示文摘目的有证据表明肠道菌群以及影响其结构和活性的因素在人类代谢、免疫和发育过程中发挥作用。我们曾报道,与久坐者相比,诸如职业运动员,配有相应饮食的极度体育活动者肠道菌群种属和代谢组分发生了改变。这次我们重点研究这些因素对菌群功能/代谢活动的影响,以进一步揭示运动者和久坐者间的差别。方法对专业国际橄榄球联盟球员(样本数为40例)和对照(样本数为46例)的肠道菌群进行代谢表型和功能宏基因组分析,并将结果与生活方式指标(比如饮食习惯)和临床评估指标(比如血清肌酸激酶)进行关联。结果与对照相比,运动员组中与肌肉更新和整体健康相关的信号通路(比如:氨基酸、抗生素生物合成和碳水化合物代谢)和肠道菌群代谢产物(比如:短链脂肪酸乙酸酯、丙酸酯和丁酸酯)有所增加。结论运动和久坐相比,其肠道菌群在宏基因组和代谢组学上比组织水平显示出更大差异,拓展了饮食.运动.肠道微生态模式新视野。 | Barton W Penney NC Cronin O Garcia-Perez I Molloy MG Holmes E Shanahan F Cotter PD O'Sullivan O 毛玲娜 宋震亚 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 3 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
| 4 | UV Absorbers for Protection and Performance 显示文摘 | Holme I | 2003 | International Dyer2003，，4： | 1 |
| 5 | Surigical treatment of intractable right sided infective endocarditis in drug addicts 25 years experience显示文摘 | Arbulu A Holmes RJ Asafaw I | 1993 | J Heart Valve Dis1993，2，2： | 1 |
| 6 | The vascular endothelial growth factor (VEGF) family:angiogenic factors in health and disease显示文摘 | Holmes D I Zachary I | | 0，，： | 1 |
| 7 | The vascular endothelial growth factor (VEGF) family:angiogenic factors in health and disease显示文摘 | Holmes DI Zachary I | | 0，，02： | 1 |
| 8 | Inflammatory markers,lipoprotein components and risk of major cardiovascular events in 65,005men and women in the Apolipoprotein MOrtality RISk study(AMORIS)显示文摘 | Holme I Aastveit AH Hammar N | 2010 | Atherosclerosis2010，213，1： | 1 |
| 9 | Advances in the Science and Technology of Paints, Inks and Related Coating :2005 显示文摘 | Holme I | 2005 | Surface Coating International Part B : Coatings Transactions2005，88，134： | 1 |
| 10 | Gut microorganisms, mammalian metabolism and personalized health care显示文摘 | Nicholson J K Holmes E Wilson I D | 2005 | NatRevMicrobiol2005，3，5： | 1 |
| 11 | Impaired motor competence in school - aged children with complex congenital heart disease 显示文摘 | Holm I Fredriksen PM Fosdahl MA | 2007 | Arch Pediatr Adolesc2007，161，10： | 1 |
| 12 | Gut microorganisms, mammalian metabolism and personalized health care显示文摘 | Nicholson J K Holmes E Wilson I D | 2005 | Nat Rev Micxobiol2005，3，： | 1 |
| 13 | High mobility nanocrystalline silicon transistors on clear plastic substrates显示文摘 | Kattamis A Z Holmes R J Cheng I C | 2006 | IEEE Electron Device Letters2006，27，1： | 1 |
| 14 | The prevalence ofosteoporosis in patients with chronic obstructive pulmonarydisease:a CROSS sectionalstudy显示文摘 | Jorgensen NR Schwarz P Holme I | 2007 | Respir Med2007，101，1： | 1 |
| 15 | Finishing for the Workplace显示文摘 | Holme I | 2003 | International Dyer2003，，7： | 1 |
| 16 | Electrostatic charging of textiles显示文摘 | Holme I McIntyre J E | 1998 | Textile Progress1998，，2： | 1 |
| 17 | Cholesterol reduction and its impaction coronary artery disease and total mortality显示文摘 | Holme I | 1995 | Am J Cardiol1995，76，9： | 1 |
| 18 | Cholesterol reduction and its impact on coronary artery diseas e and total mortality显示文摘 | Holme I | 1995 | Am J Cardiol1995，76，9： | 1 |
| 19 | Sulfur-containing amino acid requirements of growing dogs显示文摘 | Blaza S E Burger I H Holme D W | 1982 | J Nutr1982，112，： | 1 |
| 20 | Avian reovirus crC protein contain a putative fusion sequence and induces fu- sionwhen expressed in mammalian cells 显示文摘 | Theophilos M B Huang J A Holmes I | 1995 | Virology1995，208，： | 1 |
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