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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Reducing the morbidity from extravasation injuries显示文摘 | Khan M S Holmes J D | 2002 | Ann Plast Surg2002，48，6： | 3 |
| 3 | The Bioconversion of (3RS,E)-and (3RS, Z)-nerolidol into oxygenated products by streptomyces cinnamonensis 显示文摘 | Holmes D S Ashworth D M | 1990 | Helv Chim Acta1990，73，2： | 2 |
| 4 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 5 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 6 | Aspects of modeling of high voltage ferroelectric nonlinear ceramic capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1992 | IEEE Trans Compon Hydirds Manuf Technol1992，15，2： | 2 |
| 7 | Relaxation effects in high-voltage barium titanate non-linear ceramic disk capacitors 显示文摘 | CAMPBELL C K VANWYK J D HOLM M F K | 1993 | IEEE Trans Compon Hydirds Manuf Technol1993，16，4： | 2 |
| 8 | Moving or doing?Knowledge flow,problem solving,and change in industrial networks显示文摘 | ANDERSSON U HOLM D B JOHANSON M | 2007 | Journal of Business Research2007，60，： | 1 |
| 9 | The long-range scanning stage: a novel platform for scanned probe microscopy 显示文摘 | HOLMES M HOCKEN R TRUMPER D | 2000 | Prec Eng2000，24，3： | 1 |
| 10 | Genome edi- ting with engineered Zinc finger nucleases 显示文摘 | Urnov F D Rebar E J Holmes M C | 2010 | Nature Reviews Genetics2010，11，9： | 1 |
| 11 | Is Adherence to weight monitoring or weight-based diuretic self-adjustment associated with fewer heart failure-related emergency department visits or hospitalizations 显示文摘 | Jones C D Holmes G M | 2012 | J Card Fail2012，18，7： | 1 |
| 12 | Prevalence esti- mates and health-related correlates of cognitive impairment from a probability sample of community-residing Latino elders显示文摘 | Ramirez M Teresi J A Holmes D etal | 2007 | J Aging Health2007，19，4： | 1 |
| 13 | The TARGIT trial:targeted intraoperative radiation therapy versus conventional postoperative whole-breast radiotherapy after breast-conserving surgery for the management of early-stage invasive breast cancer (a trial update)显示文摘 | HOLMES DR BAUM M JOSEPH D | 2007 | Am J Surg2007，194，4： | 1 |
| 14 | Measuring ^15N-NH4^+ in marine,estuarineand fresh waters:An adaption of the ammonia diffusionmethod for samples with low ammonium concentrations显示文摘 | Holmes R M McClelland J W Sigman D M Fry B Peterson B J | 1998 | Marine Chemistry1998，60，： | 1 |
| 15 | Architecture of Entrepreneurial Learning: Ex ploring the Link among Heuristics, Knowledge, and Action显示文摘 | HOLCOMB T R IRELAND R D HOLMES R M | 2009 | Entrepreneurship Theory and Practice2009，33，1： | 1 |
| 16 | Dense array EEG: methodology and new hypothesis on epilepsy syndromes显示文摘 | Holmes M D | 2008 | Epilepsia2008，49，3： | 1 |
| 17 | Losartan, an AT1 antagonist,prevents aortic aneurysm in a mouse model of Marian syndrome显示文摘 | HABASHI J P JUDGE D P HOLM T M | 2006 | Scinece2006，312，5770： | 1 |
| 18 | Field measurements of pressures on the Texas Tech building 显示文摘 | LEVITAN M L MEHTA K C VANN W P HOLMES J D | 1991 | Journal of Wind Engineering and Industrial Aerodynamics1991，38，23： | 1 |
| 19 | Aspirin intake and survival after breast cancer显示文摘 | HOLMES M D CHEN W Y LI L | 2010 | J Clin Oncol2010，28，9： | 1 |
| 20 | Gas-particle partitioning of atmospheric Hg (11) and its effect on global mercury deposition显示文摘 | Amos H M Jacob D J Holmes C D | 2012 | Atmospheric Chemistry and Physics2012，12，1： | 1 |
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