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| 1 | Cenozoic sedimentary records and geochronological constraints of differential uplift of the Qinghai-Tibet Plateau显示文摘Geological mapping data (1:250000) in the Qinghai-Tibet Plateau and its adjacent regions reveal the sediment sequences, distribution and tectonic evolution of the 92 Tertiary remnant basins. Southern Tibet and the Yecheng area in Xinjiang, located at southern and northwestern margins of the Qinghai-Tibet Plateau, respectively, were parts of the Neo-Tethys remnant sea in the Paleogene. In southern Tibet, both the subabyssal and abyssal sequences occur at the Gyangze, Saga, Guoyala, and Sangmai areas. The deep-water facies successions outcrop in the west, whereas the shallow-water facies sequences in the east, indicating the east to the west retreat of the Neo-Tethys Ocean. The retreat of the Neo-Tethys Ocean in the east was contributed to the earlier tectonic uplift of the eastern Qinghai-Tibet Plateau. The uplift process of the Plateau from the Late Cretaceous to Pliocene is described as follows: During the Late Cretaceous, tectonic uplift of the Qinghai-Tibet Plateau occurred in the northeastern part and the configuration of the Qinghai-Tibet Plateau was characterized by rise in the northeast and depression in the west. In the Paleocene-Eocene interval, the Tengchong-Baingoin and Kuyake-Golmud areas experienced local tectonic uplifting, the West Kunlun uplift zone broadened easterly, the Qilian uplift zone broadened southerly, and the Songpan-Garzê uplift zone shrank easterly. The Oligocene configuration of the Qinghai-Tibet Plateau was characterized by mountain chains rising along its margins and sedimentary basins in the central part because of tectonic uplifts of the Gangdisê and the Himalaya blocks. Meanwhile, the Kunlun-Altyn-Qilian uplift zones have also broadened southerly and northerly. In contrast, the great uplift zones of the Gangdisê, the Himalaya, the Karakorum, and the Kunlun blocks characterize the paleogeographic contours of the Qinghai-Tibet Plateau during the Miocene-Pliocene. Additionally, the thermochronological data on tectonic uplift events in southern Tibet, West Kunlun Mountains, Altyn Tagh, eastern Tibet, and western Sichuan all suggest that the most intense deformation occurred at 13-8 Ma and since 5 Ma, respectively, corresponding to two great uplift periods in Neogene. As a result, turnover of paleogeographic configuration of the Qinghai-Tibet Plateau occurred during the Neogene, experiencing a change from high contours in the east in the pre-Oligocene to high contours in the west at the end-Pliocene. The uplift of the Qinghai-Tibet Plateau during the Cenozoic was episodic, and the uplifts of various blocks within the Plateau were spatially and chronologically different. | ZHANG KeXin WANG GuoCan CAO Kai LIU Chao XIANG ShuYuan HONG HanLie KOU XiaoHu XU YaDong CHEN FenNing MENG YanNing CHEN RuiMing | 2008 | Science China Earth Sciences2008，51，11： | 31 |
| 2 | Clay mineralogy and its palaeoclimatic significance in the Luochuan Ioess-palaeosols over -1.3 Ma, Shaanxi, northwestern China显示文摘 | Changdok WON Hanlie HONG Feng CHENG Qian FANG Chaowen WANG Lulu ZHAO Gordon Jock CHURCHMAN | 2018 | Frontiers of Earth Science2018，12，1： | 2 |
| 3 | Weathered Mantle Hosted Gold Deposit atShewushan, Hubei, Central China显示文摘A supergene gold deposit is located at Shewushan, south Hubei, Central China. The Au mass fraction of the supergene deposits ranges from 1.0.10-6 to 19.5 10-6, with an average of about 2.2 10-6. Primary gold mineralization is closely associated with the well developed faults and fractures mainly on the crest of the reverse anticline with gold mass fraction exceeding1.0 X 10-6(average 0.6 X 10-6 ), the gold occurs as small Ag-bearing particles in association with illite and kaolinite, and partly incorporated within the lattice of pyrite. Fluid inclusion studies on the gold mineralization yield trapping temperatures and pressures from 110 to 290 and 410 105 to 460 105 pa, respectively. The salinities of mineralization fluids range from 2. 6 % to 8. 4 % w(NaCl, equivalent). Calculated (18O) values and measured (D) data of the hypogene fluids indicate a meteoric origin. These fluids underwent extreme 18 O enrichment by reacting with country carbonate rock. Supergene gold minerali- zation is confined largely to the lower portion at the weathered mantle; the gold occurs as small native gold particles accompanied by clay minerals, kaolinite and illite and Mn and Fe oxides. Geochemical investigation shows that Au, together with As and Sb, decreases progressively from the top of ore body to some 2 kilometers away and define a lateral dispersion halo. It is proposed that the gold is mobilized by surficial leaching and concentrated at the lower portion of the weathering profile, and thio-sulfate may play an active role in gold dissolution and re-precipitation. | Hong Hanlie Wang Qinyan The Center for Material Research and Testing, Wuhan University of Technology, Wuhan 430070 Bian Qiujuan Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074 | 2001 | Journal of China University of Geosciences2001，12，1： | 2 |
| 4 | Computer-aided identification of protein targets of four polyphenols in Alzheimer's disease(AD)and validation in a mouse AD model显示文摘Natural polyphenols are a large class of phytochemicals with neuroprotective effects. Four polyphenolic compounds: hesperidin, icariin, dihydromyricetin and baicalin were selected to evaluate their effects on Alzheimer's disease(AD). We analyzed by an inverse docking procedure(INVDOCK) the potential protein targets of these polyphenols within the KEGG AD pathway. Consequently, their therapeutic effects were evaluated and compared in a transgenic APP/PS1 mouse model of AD. These polyphenols were docked to several targets, including APP, BACE,PSEN, IDE, CASP, calpain and TNF-a, suggesting potential in vivo activities. Five month old transgenic mice were treated with these polyphenols. Icariin and hesperidin restored behavioral deficits and ameliorated Aβ deposits in both the cortex and hippocampus while baicalin and dihydromyricetin showed no substantial effects. Our findings suggest that hesperidin and icariin could be considered potential therapeutic candidates of human AD. | Chaoyun Li Ping Meng Benzheng Zhang Hong Kang Hanli Wen Hermann Schluesener Zhiwei Cao Zhiyuan Zhang | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 5 | Immunomodulating effects of synchronised plasmapheresis and intravenous bolus cyclophosphamide in systemic lupus erythematosus显示文摘 | Hong C Zayed E | 1995 | Lupus1995，4，6： | 1 |
| 6 | Combination of surfaetant solubilization with permanganate oxidation for DNAPL remediation 显示文摘 | LI Zhaohui HONG Hanlie | 2008 | Water Res2008，42，3： | 1 |
| 7 | Resampling-based selective clustering ensembles显示文摘 | Hong Yi Kwong Sam Wang Hanli | 2009 | Pattern Recognition Let-ters2009，30，3： | 1 |
| 8 | Behaviour of gold in the weathered mantle at Shewushan,Hubei,China显示文摘 | Hong Hanlie | 2000 | Journal of Geochemical Exploration2000，68，： | 1 |
| 9 | Authigenic palygorskite in Miocene sediments in Linxia basin, Gansu, northwestern China 显示文摘 | Hong Hanlie Yu Na Xiao Ping | 2007 | Clay Minerals2007，42，： | 1 |
| 10 | Oligocene clay mineralogy of the Linxia Basin : Evidence of paleoclimatic evolution subsquent to the initial-stage uplift of the Tibetan Plateau 显示文摘 | Hanlie Hong Zhaohui Li Huijuan Xue | 2007 | Clays and Clay Miner als2007，55，5： | 1 |
| 11 | Resampling- based selective clustering ensembles显示文摘 | Hong Yi Kwong Sam Wang Hanli | 2009 | Pattem Recogni- tion Letters2009，30，： | 1 |
| 12 | Adsorption of Cr(VI) on STAC-modified rectorite显示文摘 | Hanlie Hong Wei-Teh Jiang Xiaoling Zhang Liyun Tie Zhaohui Li | 2008 | Applied Clay Science2008，，1： | 1 |
| 13 | Antibodies to brain integral membrane proteins in systemic lupus erythematosus显示文摘 | Hanly JC Hong C | 1993 | Immunol Methods1993，16，1： | 1 |
| 14 | One-pot synthesis of MnO 2 /graphene/carbon nanotube hybrid by chemical method显示文摘 | Ying Chen Yong Zhang Dognsheng Geng Ruying Li Hanlie Hong Jingzhong Chen Xueliang Sun | 2011 | Carbon2011，，13： | 1 |
| 15 | Oligocene clay mineralogy of the Linxia basin: Evidence of palaeoelimatie evolution subsequent to the initial-stage upliftof the Tibetan Plateau显示文摘 | Hong Hanlie Li Zhaohui Xue Huijuan | 2007 | Clays and Clay Minerals2007，55，： | 1 |
| 16 | Authigenic palygorskite in Miocene sediments in Linxia basin, Gansu, northwestern, China显示文摘 | Hong Hanlie Yu Na Xiao Ping et ai | 2007 | Clay Minerals2007，42，： | 1 |
| 17 | Adsorption and intercalation of ciprofloxacin on montmorillonite显示文摘 | Qingfeng Wu Zhaohui Li Hanlie Hong Ke Yin Liyun Tie | 2010 | Applied Clay Science2010，，2： | 1 |
| 18 | Immunomodulating effects of synchronosed plasmspheresis and intravenous bolus cy clophosphamide in systemic lupus erythematosus显示文摘 | Hanly JG Hong C Zayed E | 1995 | Lupus1995，4，6： | 1 |
| 19 | Clay mineralogy across the P/T boundary of the Xiakou section, China: Evidence of clay provenance and environment显示文摘 | Hong Hanlie Zhang Ning Li Zhaohui | 2008 | Clays and Clay Minerals2008，56，： | 1 |
| 20 | Oligocene clay mineralogy of the Linxia basin : evidence of palaeoclimatic evolution subsequent to the initial-stage uplift of the Tibetan Plateau 显示文摘 | Hong Hanlie Li Zhaohui Xue Huijuan | 2007 | Clays and Clay Minerals2007，55，： | 1 |
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