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您的检索式：作者名="HONGGUI MA"
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| 1 | Oncolytic adenovirus targeting LASP-1 inhibited renal cell cancerprogression显示文摘Recent studies suggested that LIM and SH3 protein 1(LASP-1)is a promising therapeutic target for renal cell cancer(RCC).This study aimed to explore the role of LASP-1 in RCC.For this purpose,LASP-1 expression in RCC tissues was analyzed by immunohistochemistry and Western blot analysis.Cell proliferation,migration,invasion,and gene expression were detected by CCK-8 assay,Transwell assay,and Western blot analysis.The results showed that LASP-1 was highly expressed in RCC,and its expression level,t was positively correlated with lymph node metastasis and tumor,nodes,and metastases(TNM)stage.The knockdown of LASP-1 expression significantly inhibited the proliferation of RCC cells,increased the apoptosis rate,and inhibited RCC cell invasion and migration by inhibiting epithelial–mesenchymal transition.We conclude that LASP-1 promotes RCC progression and metastasis and is a promising therapeutic target for RCC. | FANGHAO SUN WENCHAO ZHAO LIANSHENG ZHANG HONGGUI MA JIAN ZHOU YOUGAN CHEN JIANQUAN HOU | 2020 | BIOCELL2020，44，4： | 0 |
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