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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma显示文摘 | Oka H Chatani Y Hoshino R | 1995 | Cancer Res1995，55，： | 1 |
| 3 | Acute obstruc- tive suppurative cholangitis as a cause of acute kidney in- jury and rhabdomyolysis 显示文摘 | Hiramatsu R Hoshino J Imamura T | 2011 | Intern Med J2011，41，6： | 1 |
| 4 | Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reas- sortment 显示文摘 | Matthijnssens J Taraporewala Z F Yang H Rao S Yuan L Cao D Hoshino Y Mertens P P Carner G R McNeal M Sestak K Van Ranst M Patton J T | 2010 | J Virol2010，84，4： | 1 |
| 5 | Investigation of responders and non-responders to long-term donepezil treatment显示文摘 | Inoue J Hoshino R Nojima H | 2010 | Psychogeriatrics2010，10，： | 1 |
| 6 | Constitutive activation of mito- gen-activated protein (MAP) kinases in human renal cell carcino- ma显示文摘 | Oka H Chatani Y Hoshino R | 1995 | Cancer Res1995，55，： | 1 |
| 7 | High rate of transmission of penicillin-resistant Streptococcus pneumoniae between parents and children显示文摘 | HOSHINO K WATANABE H SUGITA R | 2002 | J Clin Microbiol2002，40，11： | 1 |
| 8 | Dimethyl Sulfoxide and Related Polar Compounds Enhance Infection of Human T Cell with HIV - 1 in Vitro 显示文摘 | SEKI J IKEDA R HOSHINO H | 1996 | Biochem Biophys Res Commun1996，227，： | 1 |
| 9 | Constitutive activation of 7the 41-/43-kDa mitogen-activated protein kinase signalingpathway in human tumors显示文摘 | Hoshino R Chatani Y Yamori T | 1999 | Oncogene1999，18，3： | 1 |
| 10 | Effect of ibudilast: a novel antiasthmatic agent, on airway hypersensitivity in bronchial asthma显示文摘 | Kawasaki A Hoshino K Osaki R | 1992 | J Asthma1992，29，4： | 1 |
| 11 | Mycobacterium tuberculosis-Induced CXCR4 and Chemokine Expression Leads to preferential X4 HIV-1 replication in human macrophages显示文摘 | Yoshihiko Hoshino Doris B Tes Gemma R | 2004 | Immunology2004，172，： | 1 |
| 12 | Computationalphysics as a new frontier 显示文摘 | Hoshino T Zeller R Dederichs P H | 1995 | Japanese Physical Society1995，56，： | 1 |
| 13 | Magnetic resonance assessment of myocardial perfusion via catheter-based ventriclecoronary vein bypass in porcine myocardial infarction model显示文摘 | Kawase Y Hoshino K | 2006 | Catheter Cardiovasc Interv2006，67，1： | 1 |
| 14 | Reduced BMP-4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT显示文摘 | Hoshino T Shimizu R Ohmori S | 2008 | Genes Cells2008，13，： | 1 |
| 15 | Lecithiniza- tion of superoxide dismutase potentiates its protective eftect a- gainst forssman antiserum-induced elevation in guinea pig airway resistance显示文摘 | IGARASHI R HOSHINO J TAKENAGA M | 1992 | J Pharmacol Exp Ther1992，262，3： | 1 |
| 16 | Lecithinized su- peroxide dismutase enhances its pharmacologic potency by in- creasing its cell membrane affinity 显示文摘 | IGARASHI R HOSHINO J OCHIAI A | 1994 | J Pharmacol Exp Ther1994，271，3： | 1 |
| 17 | Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma 显示文摘 | Oka H Chatani Y Hoshino R | 1995 | Cancer Research1995，55，： | 1 |
| 18 | Constitutive activation of the 41 -/43 - kDa mitogen - activated protein kinase signaling pathway in human tumors显示文摘 | Hoshino R Chatani Y Yamori T | 1999 | Oneogene1999，18，3： | 1 |
| 19 | Super high HAZ toughness technology with fine microstructure imparted by fine particles显示文摘 | KOJIMA A KIYOSE A UEMORI R MINAGAWA M HOSHINO M NAKASHIMA T ISHIDA K YASUI Y | 2004 | Nippon Steel Technical Report2004，380，： | 1 |
| 20 | The effect of graft tensioning in anatomic 2-bundle ACL reconstruction on knee joint kinematics 显示文摘 | Hoshino Y Kuroda R Nagamune K | 2007 | Knee Surg Sports Traumatol Arthrosc2007，15，5： | 1 |
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