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| 1 | Autologous CD34^+ and CD133^+ stem cells transplantation in patients with end stage liver disease显示文摘AIM:To assess the utility of an autologous CD34 + and CD133 + stem cells infusion as a possible therapeutic modality in patients with end-stage liver diseases.METHODS:One hundred and forty patients with endstage liver diseases were randomized into two groups.Group 1,comprising 90 patients,received granulocyte colony stimulating factor for five days followed by autologous CD34 + and CD133 + stem cell infusion in the portal vein.Group 2,comprising 50 patients,received regular liver treatment only and served as a control group.RESULTS:Near normalization of liver enzymes and improvement in synthetic function were observed in 54.5% of the group 1 patients;13.6% of the patients showed stable states in the infused group.None of the patients in the control group showed improvement.No adverse effects were noted.CONCLUSION:Our data showed that a CD34 + and CD133 + stem cells infusion can be used as supportive treatment for end-stage liver disease with satisfactory tolerability. | Hosny Salama Abdel-Rahman N Zekri Abeer A Bahnassy Eman Medhat Hanan A Halim Ola S Ahmed Ghada Mohamed Sheren A Al Alim Ghada M Sherif | 2010 | World Journal of Gastroenterology2010，16，42： | 16 |
| 2 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | Novel isoflavone, cinnamic acid, and triterpenoid glycosides in soybean molasses 显示文摘 | HOSNY M ROSAZZ P N | 1999 | J Nat Prod1999，62，6： | 1 |
| 4 | Hypoglycemic effect of oral insulin in diabetic rabbits using pH-dependent coated capsules containing sodium salicylate without and with sodium cholate 显示文摘 | HOSNY E A GHILZAI N M ALONAJAR T A | 1998 | Drug Dev Ind Pharm1998，24，3： | 1 |
| 5 | Effective intestinal absorption of insulin in diabetic rats using enteric coated capsules containing sodium salicylate 显示文摘 | Hosny E A Ghilzai N M K Al-Dhawalie A H | 1995 | Drug Dev Ind Pharm1995，21，： | 1 |
| 6 | Novel isoflavone, cinnamic acid and triterpenoid glycosides in soyben molasses显示文摘 | Hosny M H Rosazza P N | 1999 | J Nat Prod1999，62，： | 1 |
| 7 | Synthesis,spectral and antimicrobial activity studies of o-aminoacetophenone o-hydroxylbenzoyldydrazone complexes显示文摘 | Nawar N Hosny N M | 2000 | Trans Met Chem2000，25，1： | 1 |
| 8 | Synthesis,spectral and antimi-crobial activity studies of o-aminoacetophe none o-hydroxylbenzoylhydrazone complexes显示文摘 | NEWER N HOSNY N M | | 0，，01： | 1 |
| 9 | Novel isoflavone,cinnamic acid,and triterpenoid glycosides in soybean molasses显示文摘 | Hosny M Rosazza J P N | 1999 | Journal of Natural Producm1999，62，6： | 1 |
| 10 | Hypoglycemic effect of oral insulin in diabetic rabbits using pH-dependent coated capsules containing sodium salicylate without and with sodium cholate显示文摘 | HOSNY E A GHIIZAI N M AL-NAJAR T A | 1998 | Drug Dev Ind Pharm1998，24，3： | 1 |
| 11 | Synthesis, spectral and antimicrobial activity studies of o-aminoacetophenone o-hydroxylbenzoylhydrazone complexes 显示文摘 | NAWAR N HOSNY N M | 2000 | Trans Met Chem2000，25，： | 1 |
| 12 | Novel isoflavone, cinnamic acid, and triterpenoid glycosides in soybean molasses 显示文摘 | Hosny M Rosazza P N | 1999 | Journal of Natural Products1999，62，： | 1 |
| 13 | Synthesis, spectral and antimicrobial activity studies of o - aminoacet ophenone o-hydroxylbenzoylhydrazone complexes 显示文摘 | NAWAR N HOSNY N M | 2000 | Trans Met Chem2000，2，5： | 1 |
| 14 | Synthesis,spectral and antimicrobial activitystu dies of o-aminoacetophenone o-hydroxylbenzoyl-hydrazone complexes显示文摘 | NAWAR N HOSNY N M | 2000 | Trans Met Chem2000，2518，： | 1 |
| 15 | Gmelinoside A-L,twelve acylated iridoid glycosides from Gmelina arborea显示文摘 | HOSNY M ROSAZZA J P N | 1998 | J Nat Prod1998，61，6： | 1 |
| 16 | Synthesis, spectral and antimicrobiai activity studies of o-aminoacetophenone o-hydroxybenzoyl- hydrazone complexes 显示文摘 | Nawar N Hosny N M | 2000 | Trans Met Chem2000，25，1： | 1 |
| 17 | Synthesis,spectral and antimicrobial activity studies of o2aminoacetophenone o2hydroxylbenzoylhydrazone comp lexes显示文摘 | Nawar N Hosny N M | 2000 | TransMet Chem2000，25，： | 1 |
| 18 | The effect of adding long acting beta 2 agonists to inhaled corticosteroids versus increasing dose of inhaled corticosteroids in improving asthma control显示文摘 | Nabil N M Elessawy A F Hosny K M | 2014 | Egypt J Chest Dis Tuberc2014，63，4： | 1 |
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