|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Evolutionarily stable levels of vigilance as a function of group size 显示文摘 | MCNAMARA J M HOUSTON A I | 1992 | Animal Behaviour1992，43，： | 1 |
| 3 | GPU computing显示文摘 | Owens J D Houston M Luebke D | | 0，，05： | 1 |
| 4 | Surface leakage currents in SiN passivated AIGaN/GaN HFETs 显示文摘 | TAN W S UREN M J HOUSTON P A | 2006 | IEEE Electron Device Letters2006，27，1： | 1 |
| 5 | GPU Computing显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 6 | Exemplars or Beliefs? The Impact of Self- view on the Nature and Relative Influence of Brand Associations 显示文摘 | Ng S Houston M J | 2006 | Journal of Consumer Research2006，32，4： | 1 |
| 7 | Field Dependency and Brand Cognitive Structures 显示文摘 | Ng S Houston M J | 2009 | Journal of Marketing Research2009，46，2： | 1 |
| 8 | A comparison of nutrient sources and behaviour in two lowland subcatchments of the River Wye显示文摘 | Houston J A Brooker M P | | 0，，： | 1 |
| 9 | The overall gains from large banking mergers显示文摘 | HOUSTON J F RYNGAERT M D | 1994 | Journal of Banking and Finance1994，18，6： | 1 |
| 10 | GPU Computing 显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 11 | Statins and C-reactive protein levels显示文摘 | Asher J Houston M | 2007 | Clin Hypertens(Greenwich)2007，9，8： | 1 |
| 12 | Brook for GPUs:Stream computing on graphics hardware显示文摘 | Buck I Foley T Horn D R Sugerman J Fatahalian K Houston M Hanrahan P | | 0，，03： | 1 |
| 13 | Statins and C-reactive protein levels 显示文摘 | Asher J Houston M | 2007 | Clin Hypertens (Greenwich)2007，9，8： | 1 |
| 14 | Statins and C - reactive protein levels 显示文摘 | Asher J Houston M | 2007 | Clin Hypertens ( Greenwlch)2007，9，8： | 1 |
| 15 | The Audit Risk Model, Business Risk and Audit-Planning Decisions 显示文摘 | Houston R W Peters M F Pratt J H | 1999 | The Accounting Review1999，74，3： | 1 |
| 16 | The overall gains from large bank mergers 显示文摘 | Houston J H Ryngaert M | 1994 | Journal of Banking and Finance1994，18，6： | 1 |
| 17 | The Audit Risk Model, Business Risk and Audit - planning Decisions 显示文摘 | Houston R W M Peters J H Pratt | 1999 | The Accounting Review1999，174，3： | 1 |
| 18 | The Overall Gains From Large Bank Mergers显示文摘 | Houston J F Ryngaert M D | 1994 | Journal of Banking and Finance1994，，18： | 1 |
| 19 | GPU computing 显示文摘 | OWENS J D HOUSTON M LUEBKE D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 20 | GPU computing显示文摘 | OWENS J D HOUSTON M LUEBKE D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员