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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | The relationship between land use and organochlorine compounds in streambed sediments and fish in the central Columbia Plateau,Washington and Idaho,USA显示文摘 | MARK D M STEVE J G | 1997 | Environmental toxicology1997，16，7： | 1 |
| 3 | Obesitygene variant and elite endurance performance显示文摘 | Moore Geoffrey E Shuldiner Alan R Zmuda J0seph M Ferrell Robert E Mccole Steve D Hagberg James M | 2001 | Metabolism Clinical and Experimental2001，50，12： | 1 |
| 4 | An overview of the ON- IONS project: applying ontologies to integration of medical terminolo- gies显示文摘 | GANGEMI A PISANELLI D M STEVE G | 1999 | Data & Knowledge Engineering1999，31，2： | 1 |
| 5 | Clementine attitude determination and control system显示文摘 | STEVE P D LEVENSON M | 1995 | Journal of Spacecraft & Rockets1995，32，6： | 1 |
| 6 | An Overview of the ON- IONS Project: Applying Ontologies to the Integration of Medical Terminologies显示文摘 | Gangemi A Pisanelli D M Steve G | 1999 | Data & Knowledge Engineering1999，31，2： | 1 |
| 7 | The mechanical and physical properties of Compacted Graphite Iron显示文摘 | Shao S Steve D Lampic M | 1998 | Matcrialwissenschaft Und Werkstofftechnik1998，29，8： | 1 |
| 8 | The effect of rapid thermal processing (RTP) on TiN coatings deposited by PVD and the steel-turning performance of coated cemen- ted carbide 显示文摘 | Anthoy J Perry J N Steve J Bull Dmitri I P Peter C R Trevor F P Daniel E G James T John J V Robert E D Vladinmir R Alexey B M | 1999 | Surface and Coatings Technology1999，120，121： | 1 |
| 9 | The interplay between climate change, forests, and disturbances显示文摘 | VIRGINIA H D LINDA A J STEVE M | 2000 | Science of the Total Environment2000，262，： | 1 |
| 10 | Analysis of pesticide residues in food using gas chromatography-tandem mass spectrometry with a benchtop ion trap mass spectrometer显示文摘 | Steve S Robert D B John D M | | Journal of Chromatography A0，683，1： | 1 |
| 11 | The relationship between land use and organochlorine compounds in streambed sediments and fish in the central Columbis Plateau, Washington and Idaho, USA显示文摘 | Mark D M Steve J G | 1997 | Environment Toxicology1997，16，9： | 1 |
| 12 | Dexamethasone effectson ritodrine-induced cdanges in myometrial contractility and adrenergio rece Ptor function显示文摘 | Sheila M Ward M D Steve N | 1988 | Am J Obster Gynecol1988，159，6： | 1 |
| 13 | Motion from point matches:Multiplicity of solutions显示文摘 | Olivier D F Steve M | 1990 | Intermational Journal of Computer Vision1990，，4： | 1 |
| 14 | The relationship between land use and organochlorine compounds in streambed sediments and fish in the central Columbia Plateau, Washington and Idaho, USA 显示文摘 | MARK D M STEVE J G | 1997 | Environmental Toxicology1997，16，9： | 1 |
| 15 | 查看详情显示文摘 | Sudeep Bhattacharjee Booske J H Kory C L van der Weide D W Steve Limbach Gallagher S Welter J D Lopez M R Gilgenbach R M.Ives R L.Read M E Ralu Divan.Mancini D C | | 0，，： | 1 |
| 16 | Attrition of precipitated iron Fischer-Tropsch catalysts显示文摘 | KALAKKAD D S SHROFF M D STEVE K JACKSON N DATYE A K | 1995 | Appl Catal A1995，133，2： | 1 |
| 17 | Reduction and long-term immobilization of technetium by Fe(II)associated with elaymineral nontro- nite显示文摘 | Jaisi D P Dong H Plymale A E Fredrickson J K Zachara J M Steve H Liu C X | 2009 | Chemical Geology2009，264，： | 1 |
| 18 | The Relationship Between Land Use and Organochlorine Cmnpounds in Streambed Sediment and Fish in the Central Columbia Plateau, Washington and Idaho, USA 显示文摘 | MARK D M STEVE J G | 1997 | Environmental Toxicology and Chemistry1997，16，9： | 1 |
| 19 | Quorum-sensing genes in Pseudomonas aemginosa biofilms:their role and expression patterns 显示文摘 | TR D K RICHARD G STEVE M | 2001 | Appl Environ Microbiol2001，67，4： | 1 |
| 20 | Google hacking 101显示文摘 | STEVE M D | 2009 | Network Security2009，，3： | 1 |
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