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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Microstructure of poly (vinyl alcohol) hydrogels produced by freeze/thaw cycling 显示文摘 | Willcox P J Howie D W Schmidt-Rohr K et ol | 1999 | J Polym Sci Part B: Polym Phys1999，37，24： | 1 |
| 3 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 4 | Effect of soil matric potential and cell motility on wheat root colonization by fluorescent Pseudomonade suppreasive to take-all显示文摘 | Howie W J | 1987 | Phytopathology1987，77，： | 1 |
| 5 | Glomerular prolapse as precursor of one type of segmental sclerosing lesions显示文摘 | Howie A J Ferreira M A Majumdar A Lipkin G W | 2000 | J Pathol2000，190，： | 1 |
| 6 | Pectolite, rock-forming minerals显示文摘 | Deer W A Howie R A Zussman J | 1978 | Single-Chain Silicates1978，，2： | 1 |
| 7 | Postharvest fruit quality of transgenic tomatoes suppressed in expression of a ripening-related expansin 显示文摘 | BRUMEIJ D A HOWIE W J MA C | 2002 | Pestharvest Biol and Technol2002，23，： | 1 |
| 8 | Variation in cytokines induced by particles from different prosthetic materials显示文摘 | Haynes D R Boyle S J Rogers S D Howie D W Vernon-Robert B | | 0，，352： | 1 |
| 9 | Renal pathological findings in infective endocarditis 显示文摘 | Majumdar A Chowdhary S Ferreira M A Hammond L A Howie A J Lipkin G W | 2000 | Nephrol Dial Transplant2000，15，： | 1 |
| 10 | Explosive Compaction: Design, Implementation and Effectiveness 显示文摘 | Gohl W B Jefferies M G Howie J A Diggle D | 2000 | Geotechnique2000，50，6： | 1 |
| 11 | Explosive compaction: Design, implementation and effectiveness显示文摘 | GOHL W B JEFFERIES M G HOWIE J A | 2000 | Geotechnique2000，50，6： | 1 |
| 12 | Carbon dioxideemissions from vegetation-kill zones around the resurgentdome of Long Valley caldera,eastern California,USA显示文摘 | Bergfeld D Evans W C Howie J F | 2006 | Journal of Volcanology and Geothermal Research2006，152，12： | 1 |
| 13 | Effects of soil matric potential and cell motility on wheat root colonization by Pseudomonas fluorescens suppressive to take-all 显示文摘 | HOWIE W J COOK R J WELI_ER D M | 1987 | Phytopathology1987，77，： | 1 |
| 14 | The near ultra- violet spectrum of the FCO radical: Reassignment of transitions and predissociation of the electronically ex- cited state 显示文摘 | Howie W H Lane I C Orr-Ewing A J | 2000 | The Journal of Chemical Physics2000，113，17： | 1 |
| 15 | Explosive compaction:design,implementation and effectiveness显示文摘 | W B Gohl M G Jefferies J A HOWIE | 2000 | Geotechnique2000，50，6： | 1 |
| 16 | Explosive compaction: designimplemontatioa and effectiveness显示文摘 | Gohl W B Jefferies M G Howie J A | 2000 | Geotechnique2000，50，6： | 1 |
| 17 | Anisotropy correction for deviated-well sonic logs: application to seismic well tie 显示文摘 | Hornby B E Howie J M Ince D W | 2003 | Geophysics2003，68，2： | 1 |
| 18 | Explosive compaction : design, implementation and effectiveness 显示文摘 | Gohl W B Jefferies M G Howie J A | 2000 | Geotechnique2000，50，6： | 1 |
| 19 | Post - transcriptional gene silencing of ACC synthase in tomoto from cytoplas RNA degradation显示文摘 | Lee K Y Baden C Howie W J | 1997 | Plant J1997，12，5： | 1 |
| 20 | Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype显示文摘 | WELLDON K J ATKINS G J HOWIE D W | 2008 | J Biomed Mater Res A2008，84，3： | 1 |
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