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| 1 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 2 | Noise-induced hearing loss in the 21^(st) century: A research and translational update显示文摘Millions of people worldwide are exposed to harmful levels of noise daily in their work and leisure environment. This makes noise-induced hearing loss(NIHL) a major occupational health risk globally. NIHL is the second most common form of acquired hearing loss after agerelated hearing loss and is itself a major contributing factor to presbycusis. Temporary threshold shifts, once thought to be relatively harmless and recoverable, are now known to cause permanent cochlear injury leading to permanent loss of hearing sensitivity. This article reviews the current understanding of the cellular and molecular pathophysiology of NIHL with latest findings from animal models. Therapeutic approaches to protect against or to mitigate NIHL are discussed based on their proposed action against these known mechanisms of cochlear injury. Successes in identifying genes that predispose individuals to NIHL by candidate gene association studies are discussed with matched gene knockout animal models. This links to exciting developments in experimental gene therapy to replace and regenerate lost hair cells and post-noise otoprotective therapies currently being investigated in clinical trials. The aim is to provide new insights into current and projected future strategies to manage NIHL; bench to bedside treatment is foreseeable in the next 5 to 10 years. | Ann Chi Yan Wong Kristina E Froud Yves Shang-Yi Hsieh | 2013 | World Journal of Otorhinolaryngology2013，3，3： | 2 |
| 3 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 4 | A novel angiotensinconverting enzyme-related earboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E | 2000 | Circ Res2000，87，5： | 1 |
| 5 | A novel angiotensin-converting enzyme-related carboxypep- tidase ( ACE2 ) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E et a/ | 2000 | Cir Res2000，87，5： | 1 |
| 6 | Colloidal dispersion of nano- scale ZnO powders using amphibious and anionic polyelectrolytes显示文摘 | YING K L HSIEH T E HSIEH Y F | 2009 | Ceramics International2009，35，3： | 1 |
| 7 | Innovate with complexinformation technologies : A theoretical model and empirical examina-tion 显示文摘 | WANG W BUTLER J E HSIEH J J | 2008 | Journal of Computer Information Systems2008，49，1： | 1 |
| 8 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 9 | Texture and Chemical Character- istics of Soy Protein Meat Analog Extruded at High Moisture 显示文摘 | Lin S Hsieh F Huff H E | 2000 | Journal of Food Science2000，65，2： | 1 |
| 10 | Extrusion cooking of corn meal with soy fiber, salt, and sugar显示文摘 | Jin Z Hsieh F Huff H E | 1994 | Cereal Chemistry1994，71，3： | 1 |
| 11 | LIBLINEAR: a library for large linear classification 显示文摘 | Fan R E Chang K W Hsieh C J | 2008 | Journal of Machine Learning Research2008，9，： | 1 |
| 12 | Current weighting distribution control strategy for multi-inverter systems to achieve current sharing显示文摘 | WU T F WU Y E HSIEH H M | 2007 | IEEE Transactions on Power Electronics2007，22，： | 1 |
| 13 | Extrusion process parameters, sen- sory characteristics, and structural properties of a high mois- ture soy protein meat analog 显示文摘 | Lin S Huff H E Hsieh F | 2002 | Journal of Food Science2002，67，3： | 1 |
| 14 | Negative feedback regulation between microRNA let-7g and the ox-LDL receptor LOX-1 显示文摘 | CHEN K C HSIEH C HSI E D | 2011 | JCell Sci2011，5，124： | 1 |
| 15 | Ma- ternal and cord blood hormones in relation to birth size 显示文摘 | Lagiou P Samoli E Hsieh CC Lagiou A Xu B u GP | 2014 | Eur J Epidemio12014，29，5： | 1 |
| 16 | Comparison of in vivo confocal microscopic findings between epi-LASIK procedures with different management of the epithelial flaps显示文摘 | Chen W L Shen E P Hsieh Y T | | 0，，06： | 1 |
| 17 | A novel angiotensin-converting enzyme-related carboxypeptidase ( ACE2 ) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Bamnas E | 2000 | Circ Res2000，87，5： | 1 |
| 18 | Double-yield-surface model I: theory显示文摘 | HSIEH H S KAVAZANJIAN JR E BORJA R I | 1990 | Journal of Geotechnical Engineering ASCE1990，116，9： | 1 |
| 19 | Extrusion process parameters,sensory characteristics,and structural properties of a high moisture soy protein meat analog显示文摘 | Lin S Huff H E Hsieh F | 2002 | Journal of Food Science2002，67，3： | 1 |
| 20 | Analysis of crab meat volatile compounds显示文摘 | Matiella J E Hsieh T C Y | 1990 | Journal of Food Science1990，55，4： | 1 |
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