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| 1 | The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability:A mini-review显示文摘Oral administration has been widely regarded as the most conve nient,quick and safe approach compared to other routes of drug delivery.However,oral absorption of drugs is often limited due to rigorous environments and complex obstacles in gastrointestinal tract.Having received considerable attention,biomacromolecules have been applied for oral drug delivery to improve the bioavailability,which could be attributed to its stability and unique bioactivities,including intestinal adhesion,opening of epithelial tight junctions,inhibiting cell efflux and regulating relative protein expression.Specifically,enhancing intestinal permeability has been regarded as a promising strategy for improving bioavailability of oral drug delivery.In this review,a series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated.In addition,recent advances in biomacromolecules based oral delivery and related future directions are mentioned and predicted in this review article. | Min Sun Hankun Hu Leming Sun Zhen Fan | 2020 | Chinese Chemical Letters2020，31，7： | 3 |
| 2 | MOF-derived spherical Ni_(x)S_(y)/carbon with B-doping enabling high supercapacitive performance显示文摘This work uses a simple Ni-metal organic framework(Ni-MOF)to generate a uniform metal-containing carbon hybrid structure of Ni/C by in-situ pyrolysis.Then,after NaBH_(4) treatment and hydrothermal vul-canization of Ni/C,multiphase B-doped Ni_(x)S_(y) nanoparticles can be obtained and uniformly anchored in the carbon skeleton,forming a highly porous flower-shaped B-Ni_(x)S_(y)/C composite.The positive role of B doping was theoretically confirmed by Density Function Theory(DFT)calculations.The MOF-derived car-bon framework has porous,conductive,and continuous features beneficial for fast charge transfer.There are also multiple Ni-sulfide phases in B-Ni_(x)S_(y)/C,dominated by hexagonal NiS,hexagonal Ni 2 S 3,and cu-bic Ni_(3)S_(4),which give rich valance state and are expected to bring active electrochemical reactions.In addition,the boronation process by the reducing agent of NaBH_(4) is also proved beneficial to bring high capacitance,possibly due to the incorporation of more active sites by B.Therefore,the B-Ni_(x)S_(y)/C compos-ite electrode delivers a high specific capacity of 1250.4 C g^(-1) at 1 A g^(-1) and excellent rate performance.The B-Ni_(x)S_(y)/C-based asymmetric supercapacitor also shows promising prospects for future energy stor-age devices,delivering high cyclability with capacitance retention of 87.6%after 7000 cycles.This work proves the efficiency of MOF-derived carbon framework and B-doping in improving metal sulfide’s electrochemical performances. | Jingjing Hu Yan Shi Li Sun Feng Xie Kaiyue Gao Yaru Qu Hankun Tan Yihe Zhang | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 3 | Glucose-responsive,antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis显示文摘The diabetic wounds remain to be unsettled clinically,with chronic wounds characterized by drug-resistant bacterial infections,compromised angiogenesis and oxidative damage to the microenvironment.To ameliorate oxidative stress and applying antioxidant treatment in the wound site,we explore the function of folliculininteracting protein 1(FNIP1),a mitochondrial gatekeeper protein works to alter mitochondrial morphology,reduce oxidative phosphorylation and protect cells from unwarranted ROS accumulation.And our in vitro experiments showed the effects of FNIP1 in ameliorating oxidative stress and rescued impaired angiogenesis of HUVECs in high glucose environment.To realize the drug delivery and local regulation of FNIP1 in diabetic wound sites,a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving diabetic wound healing.Due to the dynamic phenylboronate ester structure with a phenylboronic acid group between hyaluronic acid(HA)and phenylboronic acid(PBA),the hydrogel is able to realize a glucose-responsive release of drugs.Fulvic acid(FA)is added in the hydrogel,which not only severs as crosslinking agent but also provides antibacterial and anti-inflammatory abilities.Moreover,the release of FEM1b-FNIP1 axis inhibitor EN106 ameliorated oxidative stress and stimulated angiogenesis through FEM1b-FNIP1 axis regulation.These in vivo and in vitro results demonstrated that accelerated diabetic wounds repair with the use of the HA-PBA-FA/EN106 hydrogel,which may provide a promising strategy for chronic diabetic wound repair. | Wenqian Zhang Kangkang Zha Yuan Xiong Weixian Hu Lang Chen Ze Lin Chenyan Yu Wu Zhou Faqi Cao Hankun Hu Bobin Mi Guohui Liu | 2023 | Bioactive Materials2023，，12： | 0 |
| 4 | Quantification of Aromatic Amino Acids in Cordyceps fungi by Micellar Electrokinetic Capillary Chromatography显示文摘A facile micellar electrokinetic chromatography(MEKC) method was developed for quantification of aromatic amino acids in Cordyceps fungi. The proposed MEKC method had linear calibration curves and detection limits at the μmol/L level. Contents of aromatic amino acids in Cordyceps were found in the range from 0.004 9 % to 0.028 0% for tryptophan(Trp), 0.036 6% to 0.078 1% for tyrosine(Tyr), and 0.029 1% to 0.136 2% for phenylalanine(Phe). Levels of amino acids in cultivated Cordyceps militaris were found higher than those in natural Cordyceps sinensis. Interestingly, the ratio of Tyr to its precursor, Phe, in C. sinensis(1.20 ± 0.091, n=3) was significantly higher than that in cultivated C. militaris(0.54 ± 0.170, n=3). This is likely because the enzyme-catalyzed in vivo biotransformation of Phe to Tyr is much more effective in natural C. sinensis, a biological hybrid of larva and parasitic fungus, than in cultivated C. militaris. | WEI Xin SU Yaxia HU Hankun LI Xiangtang XU Rui LIU Yiming | 2019 | Wuhan University Journal of Natural Sciences2019，24，3： | 0 |
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