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| 1 | Primary prevention and treatment of venous thromboembolic events in patients with gastrointestinal cancers- Review显示文摘Venous thromboembolism event(VTE) is a common and morbid complication in cancer patients. Patients with gastrointestinal cancers often suffer from symptomatic or incidental splanchnic vein thrombosis, impaired liver function and/or thrombocytopenia. These characteristics require a thorough risk/benefit evaluation for individual patients. Considering the risk factors for the development of VTE and bleeding events in addition to recent study results may be helpful for correct initiation of primary pharmacological prevention and treatment of cancer-associated thrombosis(CAT), preferably with low molecular weight heparins(LMWH). Whereas thromboprophylaxis is most often recommended in hospitalized surgical and non-surgical patients with malignancy, there is less agreement as to its duration. With regard to ambulatory cancer patients, the lack of robust data results in low grade recommendations against routine use of anticoagulant drugs. Anticoagulation with LMWH for the first months is the evidence-based treatment for acute CAT, but duration of secondary prevention and the drug of choice are unclear. Based on published guidelines and literature, this review will focus on prevention and treatment strategies of VTE in patients with gastrointestinal cancers. | Hanno Riess Piet Habbel Anja Jühling Marianne Sinn Uwe Pelzer | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 9 |
| 2 | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2. | Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 3 | Expression of Toll-like receptors in the developing brain显示文摘 | Kaul D Habbel P Derkow K | 2012 | PLo S One2012，7，5： | 1 |
| 4 | Angiotensin II modulates renal sympathetic neurotransmission through nitric oxide inAT2 receptor knockout mice显示文摘 | Stegbauer J Vonend O Habbel S | 2005 | J Hypertens2005，23，9： | 1 |
| 5 | Environmental performance of fused PM fiber couplers for fiber gyro application 显示文摘 | Anjan Y Habbel S | 1991 | IEEE Photonics Technol- ogy Letters1991，3，6： | 1 |
| 6 | Environmental performance of fused PM fiber couplers for fiber gyro application 显示文摘 | ANJAN Y HABBEL S | 1991 | IEEE Photonics Technology Letters1991，3，6： | 1 |
| 7 | Environmental performance of fused PM fiber couplers for fiber gyro application 显示文摘 | ANJAN Y HABBEL S | 1991 | IEEE Pholonics Technology Letters1991，3，6： | 1 |
| 8 | Expression of Toll- like receptors in the developing brain 显示文摘 | Kaul D Habbel P Derkow K | 2012 | PLoS One2012，7，37： | 1 |
| 9 | Colitis-associat ed colon tumorigenesis is suppressed in transgenic uiice rich in endogenous n-3 fatty acids显示文摘 | Nowak J Weylandt KH Habbel P | | 0，，09： | 1 |
| 10 | Environmental performance of fused PM fi- ber couplers for fiber gyro Application 显示文摘 | Anjan Y Habbel S | 1991 | IEEE Photonics Technology Letters1991，3，6： | 1 |
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