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| 1 | D-二聚体预测稳定型冠状动脉性心脏病患者的长期病因特异性死亡率、心血管事件和癌症显示文摘交联纤维蛋白的降解产物D-二聚体是高凝状态和血栓形成事件的标志。D-二聚体水平中度升高与血管疾病患者静脉和动脉事件的风险相关。在缺血性疾病长期普伐他汀干预(long-term intervention with pravastatin in ischemic disease,LIPID)试验中,研究者在存在其他危险因素的背景下,评估了D-二聚体水平在预测长期血管转归、病因特异性死亡率和新发癌症中的作用。 | 刘青 叶鹏 Simes J Robledo KP White HD Espinoza D Stewart RA Sullivan DR Zeller T Hague W Nestel PJ Glasziou PP Keech AC Elliott J Blankenberg S Tonkin AM LIPID study investigators | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | PTPIP51、p-Raf-1及ERK1/2在口腔鳞状细胞癌中的表达显示文摘目的探讨PTPIP51和p-Raf-1及ERK1/2在口腔鳞状细胞癌中的表达及对口腔鳞癌侵袭、转移的影响。方法收集32例口腔鳞状细胞癌及其配对癌旁正常口腔黏膜组织。用免疫荧光组织化学染色激光共聚焦显微镜检测PTPIP51与p-Raf-1蛋白在组织切片内表达及定位;PBS冲洗后对标本进行苏木精-伊红染色,普通光镜对比观察组织结构及细胞形态,同时用免疫组织化学方法(SP法)检测PTPIP51蛋白在组织和细胞内的定位;Rea-ltime PCR检测PT-PIP51与ERK1/2基因mRNA在肿瘤组织及癌旁正常口腔黏膜组织的表达情况。结果 PTPIP51与p-Raf-1蛋白在癌巢周围增殖旺盛的肿瘤细胞、间质免疫细胞及部分脉管壁内皮细胞表达阳性且2种蛋白在细胞中共定位表达。同时发现PTPIP51与ERK1/2基因mRNA在口腔鳞癌组织表达高于配对癌旁正常口腔黏膜组织,差异具有统计学意义(P<0.05);ERK1/2及PTPIP51基因mRNA表达呈正相关(r=0.641,P<0.05);两者的表达水平与患者的性别、年龄,病理分级无关,与肿瘤的TNM分级及有无淋巴结转移有关(P<0.05)。结论 PTPIP51与Raf-1可能通过Ras/Raf/MEK/ERK信号通路参与口腔鳞状细胞癌的发生、发展过程,且2种蛋白与肿瘤的侵袭、转移有密切关系。 | 肖玉霞 邵乐南 黄梅靖 李伟 Ishfa Hague | 2011 | 华中科技大学学报(医学版)2011，40，4： | 5 |
| 3 | Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells;however overexpression of bcl-2 does not protect against bak-mediated apoptosis 显示文摘 | Hague A Diaz GD Hicks DJ | 1997 | Int J Cancer1997，72，5： | 2 |
| 4 | 危害桑树的新害虫--暗翅足距小蠹显示文摘本文综述了暗翅足距小蠹(Xylosandrus crassiusculus(Motschulsky))的研究概况,并首次记述了其可危害桑(Morus alba L.),明确了该虫为小蠹亚科(Scolytinae)江西省新纪录种。文中重点介绍了该虫的分类地位,形态特征,地理分布,寄主植物,危害特点和生物学习性,并在文章讨论部分提出了相应的防治策略。 | 周诠 曹红妹 徐业 彭晓虹 吕佳 Hagus Tanro 王建国 | 2020 | 植物检疫2020，34，1： | 2 |
| 5 | 从难选矿石中浸出金(文献综述)显示文摘本文对最近文献有关难选金矿石的预处理方法进行综述。当金细粒浸染于硫化矿、含砷硫化物、碲化物、碳质和粘土矿物中时,直接采用碱性氰化法提金效果不好。但通过热氧化(如焙烧)、化学氧化(如酸浸、加压酸浸或碱浸)或生物氧化(如氧化铁硫杆菌的生物浸出)的预处理可使金从难选矿物中解离出来,然后用碱性氰化法从该氧化产物中回收金。 | K E Hague 韦华祖 | 1990 | 有色矿冶1990，6，6： | 2 |
| 6 | B2B市场的品牌效应显示文摘白皮书也被称之为问题报告、意见书或思想领导报告,用于讨论与特定行业相关的一些问题。发表白皮书的目的是教育;向非专业人士阐明某一问题/主题的概要内容;概述新业务发展的意义;陈述针对特定问题或市场的相应解决方法;引入新的业务观念和思维方式。 | Paul Hague | 2007 | 成功营销2007，，7： | 2 |
| 7 | Pathogenicity of bacterium, Xenorhabdus nematophila isolated from entomopathogenic nematode (Steinernema carpocapsae) and its secretion against Galleria mellonella larvae显示文摘The entomopathogenic bacterium, Xenorhabdus nematophila was isolated from the hemolymph of Galleria mel- lonella infected with Steinernema carpocapsae. The bacterial cells and its metabolic secretions have been found lethal to the Galleria larvae. Toxic secretion in broth caused 95% mortality within 4 d of application whereas the bacterial cells caused 93% mortality after 6 d. When filter and sand substrates were compared, the later one was observed as appropriate. Similarly, bacterial cells and secretion in broth were more effective at 14% moisture and 25 °C temperature treatments. Maximum insect mortality (100%) was observed when bacterial concentration of 4×106 cells/ml was used. Similarly, maximum bacterial cells in broth (95%) were penetrated into the insect body within 2 h of their application. However, when stored bacterial toxic secretion was applied to the insects its efficacy declined. On the other hand, when the same toxic secretion was dried and then dissolved either in broth or water was proved to be effective. The present study showed that the bacterium, X. nematophila or its toxic secretion can be used as an important component of integrated pest management against Galleria. | MAHAR Ali Nawaz MUNIR Muhammad ELAWAD Sami GOWEN Simon Richard HAGUE Nigel Graham Meckenzi | 2005 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2005，6，6： | 2 |
| 8 | Mechanical within-row weed control for transplanted crops using computer vision显示文摘 | TILLETT N D HAGUE T GRUNDY A C | 2007 | Biosystems Engineering2007，26，： | 1 |
| 9 | Expression of the Hypoxically Regulated Angiogenic Factor Adrenomedullin Correlates with Uterine Leiomyoma Vascular Density显示文摘 | Stephen Hague Lyna Zhang Martin K | 2000 | Clinical Cancer Research Vol2000，6，7： | 1 |
| 10 | Jugular foramen: microscopic anatomic features and implications for neural preservation with reference to glomus tumors involving the temporal bone显示文摘 | Sen C Hague K Kacchara R | 2001 | Neurosurgery2001，48，4： | 1 |
| 11 | Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ACT values显示文摘 | Mofrad P Contos MJ Hague M | 2003 | Hopatology2003，37，6： | 1 |
| 12 | Metformin Versus insulin for the treatment of gestational diabetes 显示文摘 | Rowan JA Hague WM Gao W | 2008 | N Engl J Med2008，358，19： | 1 |
| 13 | Some characteristics of high strength fiber reinforced lightweight aggregate concrete 显示文摘 | KAYALI O HAGUE M N ZHU B | 2003 | Cement and Concrete Composites2003，25，2： | 1 |
| 14 | Processing nanocrystaUine ceramics for applications in superplasticity 显示文摘 | MAYO M J HAGUE D C CHEN D J | 1993 | Mater Sci Eng A1993，166，12： | 1 |
| 15 | Row-following accuracy of an autonomous vision-guided agricultural vehicle 显示文摘 | Marchant J A Hague T Tillett N D | 1997 | Computers and Electronics in Agriculture1997，16，2： | 1 |
| 16 | End-digit preference in blood pressure recordings of patients with ischaemic heart disease in primary care显示文摘 | Belsey J Hague N | 2004 | J Hum Hypertens2004，18，： | 1 |
| 17 | Arabidopsis to Rice:Applying knowledge from a weed to enhance our understanding of a crop species显示文摘 | Rensink W Buell C | 2004 | Plant Physiology2004，135，： | 1 |
| 18 | PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non-estrogenic mechanism in the human endometrium 显示文摘 | Zhao Y Hague S Manek S el al | 1998 | Oncogone1998，16，3： | 1 |
| 19 | Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumor growth显示文摘 | Oehler MK Norbury C Hague S | 2001 | Oncogene2001，20，23： | 1 |
| 20 | bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells;however overexpression of bcl-2 does not protect against bak-mediated apoptosis 显示文摘 | Hague A Diaz GD Hicks DJ | 1997 | Int J Cancer1997，72，5： | 1 |
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