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| 1 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 2 | Quantitative study of prostate cancer using three dimensional fiber tractography显示文摘AIM:To investigate feasibility of a quantitative study of prostate cancer using three dimensional(3D)fiber tractography.METHODS:In this institutional review board approved retrospective study,24 men with biopsy proven prostate cancer underwent prostate magnetic resonance imaging(MRI)with an endorectal coil on a 1.5 T MRI scanner.Single shot echo-planar diffusion weighted images were acquired with b = 0.600 s/mm^2,six gradient directions.Open-source available software Track Vis and its Diffusion Toolkit were used to generate diffusion tensor imaging(DTI)map and 3D fiber tracts.Multiple 3D spherical regions of interest were drawn over the areas of tumor and healthy prostatic parenchyma to measure tract density,apparent diffusion coefficient(ADC)and fractional anisotropy(FA),which were statistically analyzed.RESULTS:DTI tractography showed rich fiber tract anatomy with tract heterogeneity.Mean tumor region and normal parenchymal tract densities were 2.53 and 3.37 respectively(P < 0.001).In the tumor,mean ADC was 0.0011 × 10^(-3 )mm^2/s vs 0.0014 × 10^(-3) mm^2/s in the normal parenchyma(P < 0.001).The FA values for tumor and normal parenchyma were 0.2047 and 0.2259 respectively(P = 0.3819).CONCLUSION:DTI tractography of the prostate is feasible and depicts congregate fibers within the gland.Tract density may offer new biomarker to distinguish tumor from normal tissue. | Sandeep Hedgire Alexey Tonyushkin Aoife Kilcoyne Jason A Efstathiou Peter F Hahn Mukesh Harisinghani | 2016 | World Journal of Radiology2016，8，4： | 4 |
| 3 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 4 | Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity显示文摘 | Mavros A Hahn M Wieland I | 2002 | J Oral Pathol Med2002，31，5： | 1 |
| 5 | Comparison between Taq DNA polymerase and its Stoffel fragment for quantitative real-time PCR with hybridization probes显示文摘 | Wilhelm J Pingoud A Hahn M | 2001 | Bioteehniques2001，30，： | 1 |
| 6 | Real-time PCR- based method for the estimation of genome sizes显示文摘 | Wilhelm J Pingoud A Hahn M | 2003 | Nucleic Acids Research2003，31，10： | 1 |
| 7 | Carp preproinsulin cDNA sequence and evolution of insulin genes 显示文摘 | HAHN V WINKLER J RAPOPORT T A | 1983 | Nucleic Acids Research1983，11，13： | 1 |
| 8 | Damage and failure behaviour of a woven C/SiC material显示文摘 | Hahn L Ansorge F Brückner-foit A | 1997 | Journal of Materials Science1997，32，： | 1 |
| 9 | Transient rotordynamic mo-deling of rolling element bearing systems显示文摘 | Liew A Feng N Hahn E J | 2002 | ASME Journal of Engineering for Gas Turbines and Power2002，124，： | 1 |
| 10 | Analysis of bacterial community structure in bulk soil by in situ hybridization 显示文摘 | Zarda B Hahn D Chatzinotas A | 1997 | Arch Microbiol1997，168，： | 1 |
| 11 | Laboratory signs of activated coagulation are common in Henoch -SchOnlein purpura显示文摘 | Brendel - Muller K Hahn A Schneppenheim R | 2001 | Pediatr Nephrol2001，16，12： | 1 |
| 12 | Floating ring squeeze film damp- er : theoretical analysis 显示文摘 | Rezvani M A Hahn E J | 2000 | Tribology International2000，33，3： | 1 |
| 13 | Pancreatic cysts 3 em or smaller:how aggressive should treatment be? 显示文摘 | Sahani DV Saokar A Hahn PF | 2006 | Radiology2006，238，3： | 1 |
| 14 | Impact of future climate and land use change on non-timber forest product provision in Benin,West Africa:Linking niche-based modeling with ecosystem service values显示文摘 | Heubes J Heubach K Schmidt M Wittig R Zizka G Nuppenau E A Hahn K | 2012 | Economic Botany2012，66，4： | 1 |
| 15 | Rules for making human tumor cells 显示文摘 | HAHN W C WEINBERG R A | 2002 | N Engl J Med2002，347，20： | 1 |
| 16 | Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms显示文摘 | Li Y Zimmermann B Rusterholz C Kang A Holzgreve W Hahn S | 2004 | Clin Chem2004，50，： | 1 |
| 17 | Linking purchasing to corporate competitive strategy显示文摘 | Kim K Y Hahn C K | 1992 | International Journal of Purchasing and Materials Management1992，18，4： | 1 |
| 18 | Elasto-plastic coupled temperature-displacement f'mite element analysis of two-dimensional rolling-sliding contact with a translating heat source 显示文摘 | Kulkami S M Rubin C A Hahn G T | 1991 | Journal of Tribology1991，113，1： | 1 |
| 19 | High-performance liquid chromatographic determination of bathmochrorne absorption shifts显示文摘 | STEIN J HAHN A REHNER G | 1995 | Journal of Chromatography B: Biomedical Sciences and Applications1995，665，1： | 1 |
| 20 | Effect of radial stress relaxation on fibre stress in filament winding of thick composites显示文摘 | Keppner Evan A Hahn H Thomas | 1995 | Composites Manufacturing1995，6，1： | 1 |
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