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| 1 | Associations between Mycobacterium tuberculosis Beijing geno- type and drug resistance to four first-line drugs: a survey in China显示文摘在中国的 Mycobacterium 肺结核的基因差异上的调查证明了北京遗传型紧张起一个主导的作用。学习在 M. 之间的协会 ? 肺结核北京遗传型和药抵抗显型, 1286 M。肺结核临床和病人的流行病学、临床的信息孤立从肺结核(TB ) 的中心被收集在在中国的北京自治市和九个省或自治区域的预防和控制或 TB 医院。测试的药抵抗在所有 isolates 上被进行到四首要的 anti-TB 药(异菸肼, rifampicin,链球菌,和 ethambutol ) 。585 紧张的一个总数被发现对四 anti-TB 药中的至少一个抵抗。北京家庭紧张由 499 组成了(53.20%) 药敏感的紧张并且 439 (46.80%) 药抵抗的紧张,而非北京家庭紧张包括了 202 (58.05%) 药敏感的紧张并且 146 (41.95%) 药抵抗的紧张。没有重要差别在流行被观察(c 2=2.41, P > 0.05 ) 在在北京家庭紧张之中的药抵抗、药敏感的紧张之间。药抵抗的 monoresistance, multidrug 抵抗的 TB,和地理分发的分析没发现在 M. 之间的任何关系 ? 在中国的肺结核北京遗传型和药抵抗显型。结果证实了北京遗传型,占优势的 M。在中国的肺结核遗传型,没与药抵抗被联系。 | Haican Liu Yuanyuan Zhang Zhiguang Liu Jinghua Liu Yolande Hauck Jiao Liu Haiyan Dong Jie Liu Xiuqin Zhao Bing Lu Yi Jiang Gilles Vergnaud Christine Pource Kanglin Wan | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 2 | Preliminary Study of the Protectiveness of Vaccination Against the COVID-19 in the Outbreak of VOC Omicron BA.2—Jilin City,Jilin Province,China,March 3–April 12,2022显示文摘Summary What is already known about this topic?An outbreak of coronavirus disease 2019(COVID-19)of Omicron BA.2 emerged in Jilin City since March 3,2022,which involved in 27,036 cases by April 12.The vaccination program with inactivated COVID-19 vaccines has been implemented since the beginning of 2021.What is added by this report?The incidences of moderate,severe,and critical cases in the whole population of the group of 0+1 dose were 1.82-,9.49-,and 3.85-fold higher than those in the group of 2 doses,and 5.03-,44.47-,and∞-fold higher than those received 3 doses vaccination.For the population≥60 years,the incidences of moderate,severe,and critical cases in the group of 0+1 dose were 29.92,9.62,and 4.27 per 100,000,showing 4.13-,43.72-,and 4.85-fold higher than 2 doses,as well as 13.28-,22.37-,and∞-fold higher than 3 doses.What are the implications for public health practice?The incidences of each type of COVID-19 in the population who were fully vaccinated or booster vaccinated in Jilin City were significantly lower than those who were unvaccinated and/or partially vaccinated.Booster vaccination with homologous inactivated vaccines induces stronger protectiveness for COVID-19 caused by variant of concern(VOC)Omicron. | Xuebin Fan Shan Lu Lu Bai Haican Liu Junshao Fu Xiaoxun Jin Yulong He Jinxing Lu Xiaoping Dong | 2022 | China CDC weekly2022，4，18： | 3 |
| 3 | A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus显示文摘The complete genome of methanol-utilizing Amycolatopsis methanolica strain 239T was generated,revealing a single 7,237,391 nucleotide circular chromosome with 7074 annotated protein-coding sequences(CDSs).Comparative analyses against the complete genome sequences of Amycolatopsis japonica strain MG417-CF17T,Amycolatopsis mediterranei strain U32 and Amycolatopsis orientalis strain HCCB10007 revealed a broad spectrum of genomic structures,including various genome sizes,core/quasi-core/non-core configurations and different kinds of episomes.Although polyketide synthase gene clusters were absent from the A.methanolica genome,12 gene clusters related to the biosynthesis of other specialized(secondary)metabolites were identified.Complete pathways attributable to the facultative methylotrophic physiology of A.methanolica strain 239T,including both the mdo/mscR encoded methanol oxidation and the hps/hpi encoded formaldehyde assimilation via the ribulose monophosphate cycle,were identified together with evidence that the latter might be the result of horizontal gene transfer.Phylogenetic analyses based on 16S rDNA or orthologues of AMETH_3452,a novel actinobacterial class-specific conserved gene against 62 or 18 Amycolatopsis type strains,respectively,revealed three major phyletic lineages,namely the mesophilic or moderately thermophilic A.orientalis subclade(AOS),the mesophilic Amycolatopsis taiwanensis subclade(ATS)and the thermophilic A.methanolica subclade(AMS).The distinct growth temperatures of members of the subclades correlated with corresponding genetic variations in their encoded compatible solutes.This study shows the value of integrating conventional taxonomic with whole genome sequence data. | Biao Tang Feng Xie Wei Zhao Jian Wang Shengwang Dai Huajun Zheng Xiaoming Ding Xufeng Cen Haican Liu Yucong Yu Haokui Zhou Yan Zhou Lixin Zhang Michael Goodfellow Guo-Ping Zhao | 2016 | Synthetic and Systems Biotechnology2016，1，3： | 1 |
| 4 | Research on a stock-matching trading strategy based on bi-objective optimization显示文摘In recent years,with strict domestic financial supervision and other policy-oriented factors,some products are becoming increasingly restricted,including nonstandard products,bank-guaranteed wealth management products,and other products that can provide investors with a more stable income.Pairs trading,a type of stable strategy that has proved efficient in many financial markets worldwide,has become the focus of investors.Based on the traditional Gatev-Goetzmann-Rouwenhorst(GGR,Gatev et al.2006)strategy,this paper proposes a stock-matching strategy based on bi-objective quadratic programming with quadratic constraints(BQQ)model.Under the condition of ensuring a long-term equilibrium between pairedstock prices,the volatility of stock spreads is increased as much as possible,improving the profitability of the strategy.To verify the effectiveness of the strategy,we use the natural logs of the daily stock market indices in Shanghai.The GGR model and the BQQ model proposed in this paper are back-tested and compared.The results show that the BQQ model can achieve a higher rate of returns. | Haican Diao Guoshan Liu Zhuangming Zhu | 2020 | Frontiers of Business Research in China2020，14，1： | 0 |
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