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| 1 | Employing a novel bioelastomer to toughen polylactide显示文摘 | Hailan Kang Bo Qiao Runguo Wang Zhao Wang Liqun Zhang Jun Ma Phil Coates | 2013 | Polymer2013，，9： | 1 |
| 2 | Suppression of osteosarcoma progression by engineered lymphocyte-derived proteomes显示文摘Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents.Based on this strategy,induced tumor-suppressing cells(iTSCs)have been generated from tumor cells and mesenchymal stem cells.Here,we examined the possi-bility of generating iTSCs from lymphocytes by activating PKA signaling for suppressing the pro-gression of osteosarcoma(OS).While lymphocyte-derived CM did not present anti-tumor capabilities,the activation of PKA converted them into iTSCs.Inhibiting PKA conversely gener-ated tumor-promotive secretomes.In a mouse model,PKA-activated CM suppressed tumorinduced bone destruction.Proteomics analysis revealed that moesin(MSN)and calreticulin(Calr),which are highly expressed intracellular proteins in many cancers,were enriched in PKA-activated CM,and they acted as extracellular tumor suppressors through CD44,CD47,and CD91.The study presented a unique option for cancer treatment by generating iTSCs that secret tumor-suppressive proteins such as MSN and Calr.We envision that identifying these tu-mor suppressors and predicting their binding partners such as CD44,which is an FDA-approved oncogenic target to be inhibited,may contribute to developing targeted protein therapy. | Kexin Li Xun Sun Hudie Li Hailan Ma Meng Zhou Kazumasa Minami Keisuke Tamari Kazuhiko Ogawa Pankita HPandya MReza Saadatzadeh Melissa AKacena Karen EPollok Bai-Yan Li Hiroki Yokota | 2023 | Genes & Diseases2023，10，4： | 0 |
| 3 | A Critical Role for γCaMKII in Decoding NMDA Signaling to Regulate AMPA Receptors in Putative Inhibitory Interneurons显示文摘CaMKII is essential for long-term potentiation(LTP),a process in which synaptic strength is increased following the acquisition of information.Among the four CaMKII isoforms,γCaMKII is the one that mediates the LTP of excitatory synapses onto inhibitory interneurons(LTPE→I).However,the molecular mechanism underlying howγCaMKII mediates LTPE→I remains unclear.Here,we show thatγCaMKII is highly enriched in cultured hippocampal inhibitory interneurons and opts to be activated by higher stimulating frequencies in the 10–30 Hz range.Following stimulation,γCaMKII is translocated to the synapse and becomes co-localized with the postsynaptic protein PSD-95.Knocking downγCaMKII prevents the chemical LTP-induced phosphorylation and trafficking of AMPA receptors(AMPARs)in putative inhibitory interneurons,which are restored by overexpression ofγCaMKII but not its kinase-dead form.Taken together,these data suggest thatγCaMKII decodes NMDAR-mediated signaling and in turn regulates AMPARs for expressing LTP in inhibitory interneurons. | Xingzhi He Yang Wang Guangjun Zhou Jing Yang Jiarui Li Tao Li Hailan Hu Huan Ma | 2022 | Neuroscience Bulletin2022，38，8： | 0 |
| 4 | Quantum learning control using differential evolution with equally-mixed strategies显示文摘学习控制在量信息技术作为一条强大的途径被认出了。在这份报纸,我们扩大微分进化(DE ) 的应用程序为各种各样的量系统设计最佳的控制。各种各样的 DE 方法被介绍并且分析,并且在同等地混合的策略展示的 EMSDE 为量控制被采用。量的二个类控制问题,包括四水平的开的量整体和量的控制超导的系统,被调查为听说控制量系统表明 EMSDE 的性能。数字结果为各种各样的量系统验证 EMSDE 方法的有效性并且为复杂的量控制问题显示出潜力。 | Hailan MA Daoyi DONG Chuan-Cun SHU Zhangqing ZHU Chunlin CHEN | 2017 | Control Theory and Technology2017，15，3： | 0 |
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