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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients:Six case reports显示文摘BACKGROUND Epstein-Barr virus associated smooth muscle tumor(EBV-SMT)is a rare oncological entity.However,there is an increasing incidence of EBV-SMTs,as the frequency of organ transplantation and immunosuppression grows.EBV-SMT diagnosis relies on histopathology and immunochemical staining to distinguish it from post-transplant lymphoproliferative disorder(PTLD).There is no clear consensus on the treatment of EBV-SMTs.However,surgical resection,chemotherapy,radiation therapy,and immunosuppression reduction have been explored with varying degrees of success.CASE SUMMARY Our case series includes six cases of EBV-SMTs across different age groups,with different treatment modalities,adding to the limited existing literature on this rare tumor.The median latency time between immunosuppression and disease diagnosis is four years.EBV-SMTs present with variable degrees of aggressiveness and seem to have worse clinical outcomes in patients with tumor multiplicity and worse immunocompetency.CONCLUSION It is imperative to continue building on this knowledge and keeping EBV-SMTs on the differential in immunocompromised individuals. | Afshin A Khan Bassam N Estfan Anirudh Yalamanchali Djibril Niang Erica C Savage Clifton G Fulmer Hailey L Gosnell Jamak Modaresi Esfeh | 2022 | World Journal of Clinical Oncology2022，13，6： | 2 |
| 3 | Study quality and evidence of benefit in recentassessments of te!emedicine显示文摘 | Hailey D Ohinmaa A Roine R | 2004 | J Telemed Telecare2004，10，： | 1 |
| 4 | Minimum Sample Size Single Sampling Plans:a Computerized Approach 显示文摘 | Hailey W A | 1980 | Journal of Quality Technology1980，12，4： | 1 |
| 5 | Proton magnetic resonance techniques for characterization of water in wood: Application to white spruce显示文摘 | Araujo C D MacKay A L Hailey J R T | 1992 | Wood Sci Technol1992，26，2： | 1 |
| 6 | Sutdy quality and evidence of benefit in recent assessments of telemedicine显示文摘 | Hailey D ohinmaa A Roine R | 2004 | J Telemed Telecare2004，10，6： | 1 |
| 7 | Detection and diagnosis of plant-wide oscillations from industrial data using the spectral envelope method 显示文摘 | Hailei Jiang Shoukat Choudhury M A A Sirish L Shah | 2007 | Journal of Process Control2007，17，2： | 1 |
| 8 | Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modeling mixture analysis显示文摘 | DEBRAEKELEER K CUESTA-SANCHEZ F HAILEY P A | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，17，1： | 1 |
| 9 | Assessing telemedicine:a systematic review of the literature显示文摘 | Roine R Ohinmaa A Hailey D | 2001 | CMAJ2001，165，6： | 1 |
| 10 | Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succinyl- choline-induced fasciculations and myalgia: a comparison with placebo显示文摘 | Joshi GP Hailey A Cross S | 1999 | J Clin Anesth1999，11，8： | 1 |
| 11 | Elements for assessment of telemedicine applications显示文摘 | Ohinmaa A Hailey D Roine R | 2001 | Int J Technol Assess Health Care2001，17，3： | 1 |
| 12 | Review of attitude representations used for aircraft kinematics显示文摘 | PHILLIPS W F HAILEY C E GEBERT G A | 2001 | Journal of Aircraft2001，，38： | 1 |
| 13 | Strategic goals and practices of innovative family business 显示文摘 | MCCANN J E LEON-GUERRERO A Y HAILEY J D | 2001 | Journal of Small Business Management2001，39，1： | 1 |
| 14 | An in vivo quantitative angiogenesis model using tumor ceils entrapped in alginate 显示文摘 | PLUNKRTT M L HAILEY J A | 1990 | Lab Invest1990，62，4： | 1 |
| 15 | Assessing telemedicine: a systematic review of the literature显示文摘 | Roine R Ohinmaa A Hailey D | 2001 | CMAJ2001，165，8： | 1 |
| 16 | Mitochondria supply membranes for autophagosome bi- ogenesis during starvation 显示文摘 | Hailey D W Rambold A S Satpute - Krishnan P | 2010 | Cell2010，141，4： | 1 |
| 17 | AIDS, drought, and child malnutrition in southern Afrioa显示文摘 | MASON J B BAILES A MASON K E YAMBI 0 JONSSON U HUDSPETH C HAILEY P KENDLE A BRUNET D MARTELP | 2005 | PublicHealth Nutrition2005，8，6： | 1 |
| 18 | Review of Atti- for Aircraft Kinematics 显示文摘 | Philips W F Hailey C E tude Representations Used Gebert G A | 2001 | Journal of Aircraft2001，38，4： | 1 |
| 19 | Effects of pretreatment with cisatracurium, rocuronium, and d-tubocurarine on succi- nylcholine-induced faseiculations and myalgia: a comparison with placebo 显示文摘 | Joshi GP Hailey A Cross S | 1999 | J Clin Anesth1999，11，8： | 1 |
| 20 | Effects of Spraying the Herbicides 2,4-Dand 2,4,5-T on a Population of the Tortoise Testudo hermanni inSouthern Greece 显示文摘 | Willemsen R E Hailey A | 2001 | Environ Pollut2001，113，1： | 1 |
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