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| 1 | Defective Kernel 39 encodes a PPR protein required for seed development in maize显示文摘RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat(PPR)proteins. Here, we report the map-based cloning and molecular characterization of a defective kernel mutant dek39 in maize. Loss of Dek39 function leads to delayed embryogenesis and endosperm development, reduced kernel size, and seedling lethality. Dek39 encodes an E subclass PPR protein that targets to both mitochondria and chloroplasts, and is involved in RNA editing in mitochondrial NADH dehydrogenase3(nad3) at nad3-247 and nad3-275. C-to-U editing of nad3-275 is not conserved and even lost in Arabidopsis, consistent with the idea that no close DEK39 homologs are present in Arabidopsis. However, the amino acids generated by editing nad3-247 and nad3-275 are highly conserved in many other plant species, and the reductions of editing at these two sites decrease the activity of mitochondria NADH dehydrogenase complex I,indicating that the alteration of amino acid sequence is necessary for Nad3 function. Our results indicate that Dek39 encodes an E sub-class PPR protein that is involved in RNA editing of multiple sites and is necessary for seed development of maize. | Xiaojie Li Wei Gu Silong Sun Zongliang Chen Jing Chen Weibin Song Haiming Zhao Jinsheng Lai | 2018 | Journal of Integrative Plant Biology2018，60，1： | 6 |
| 2 | Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors显示文摘The spatiotemporal distribution of cytokines orchestrates immune responses in vivo,yet the underlying mechanisms remain to be explored.We showed here that the spatial distribution of interleukin-4(IL4)in invariant natural killer T(iNKT)cells regulated crosstalk between iNKT cells and dendritic cells(DCs)and controlled iNKT cell-mediated T-helper type 1(Th1)responses.The persistent polarization of IL4 induced by strong lipid antigens,that is,α-galactosylceramide(αGC),caused IL4 accumulation at the immunological synapse(IS),which promoted the activation of the IL4R-STAT6(signal transducer and activator of transcription 6)pathway and production of IL12 in DCs,which enhanced interferon-γ(IFNγ)production in iNKT cells.Conversely,the nonpolarized secretion of IL4 induced by Th2 lipid antigens with a short or unsaturated chain was incapable of enhancing this iNKT cell-DC crosstalk and thus shifted the immune response to a Th2-type response.The nonpolarized secretion of IL4 in response to Th2 lipid antigens was caused by the degradation of Cdc42 in iNKT cells.Moreover,reduced Cdc42 expression was observed in tumorinfiltrating iNKT cells,which impaired IL4 polarization and disturbed iNKT cell-DC crosstalk in tumors. | Lu Wang Zhilan Liu Lili Wang Qielan Wu Xiang Li Di Xie Huimin Zhang Yongdeng Zhang Lusheng Gu Yanhong Xue Ting Yue Gang Liu Wei Ji Haiming Wei Tao Xu Li Bai | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 3 | Application of Optical Tweezers in the Research of Molecular Interaction between Lymphocyte Function Associated Antigen-1 and Its Monoclonal Antibody显示文摘Lymphocyte function associated antigen-1 (CD11a/CD18, LFA-1) plays an important role in the structure of the immunological synapse and is required for efficient lysis of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. To study the activation mode of LFA-1 on the NK cell surface, optical tweezers were used in the work. As an emerging technology, optical tweezers are widely used to manipulate microscopic objects and measure the forces of molecular interactions in the field of biological research. In our study, a new platform was constructed to study the single molecular behavior of receptor on cell surface using optical tweezers. Based on the platform, the interaction between an NK cell and a polystyrene microsphere coated with anti-LFA-1 antibody was observed. The result confirmed that the adhesion forces between an NK cell and a polystyrene bead were time-dependent. According to our findings, we propose that anti-LFA-1 antibody may cause the clustering of LFA-1 on NK cell surface. | Haodong Chen Kuikui Ge Yinmei Li Jianguang Wu Yongqiang Gu Haiming Wei Zhigang Tian | 2007 | Cellular & Molecular Immunology2007，4，3： | 3 |
| 4 | Giant Electrocaloric Response Over A Broad Temperature Range in Modified BaTiO<sub>3</sub> Ceramics显示文摘 | Xiao‐Shi Qian Hui‐Jian Ye Ying‐Tang Zhang Haiming Gu Xinyu Li C. A. Randall Q. M. Zhang | 2014 | Adv Funct Mater2014，，9： | 1 |
| 5 | Large Electrocaloric Effect in a Dielectric Liquid Possessing a Large Dielectric Anisotropy Near the Isotropic–Nematic Transition显示文摘 | Xiao‐Shi Qian Sheng‐Guo Lu Xinyu Li Haiming Gu Liang‐Chy Chien Qiming Zhang | 2013 | Adv Funct Mater2013，，22： | 1 |
| 6 | Least-squares Mixed Finite Element Method for Sobolev Equations显示文摘 | Haiming Gu Danping Yang | 2000 | India J appl Math2000，31，5： | 1 |
| 7 | Chem- ical Looping Combustion of Biomass/Coal with Natural Iron Ore as Oxygen Carrier in a Continuous Reactor 显示文摘 | GU Haiming SHEN Laihong XIAO Jun | 2010 | Energy gc Fuels2010，25，1： | 1 |
| 8 | Simulation of chip- size electrocaloric refrigerator with high cooling-power density 显示文摘 | Gu Haiming Brent Craven Zhang Q M | 2013 | Applied Physics Letters2013，102，12： | 1 |
| 9 | A chip scale electro- caloric effect based cooling device 显示文摘 | Gu Haiming Qian Xiaoshi Zhang Q M | 2013 | Applied Physics Letters2013，102，12： | 1 |
| 10 | Chemical looping combustion of biomass/coal with natural iron ore as oxygen carrier in a continuous reactor 显示文摘 | Gu Haiming Shen Laihong Xiao Jun | 2011 | Energy & Fuels2011，25，1： | 1 |
| 11 | Chem- ical Looping Combustion of Biomass/Coal with Natural Iron Ore as Oxygen Carrier in a Continuous Reactor 显示文摘 | GU Haiming SHEN Laihong XIAO Jun | 2010 | Energy z 5els2010，25，1： | 1 |
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