|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Visual neuroscience research in China显示文摘Historically,vision research in China was one of a few distinct research programs within the Chinese Academy of Sciences(CAS).With improved funding opportunities and research environment in neuroscience,vision research at several research institutes within the academy has made significant progress not only in the quantity of publications,but also in the quality of the work.Based on our own expertise,this review is mainly focused on the findings that have advanced the understanding of visual processing in the central visual pathway,visual perceptual learning,visual development and eye diseases. | YAO HaiShan,LU HaiDong & WANG Wei Institute of Neuroscience,State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China | 2010 | Science China(Life Sciences)2010，53，3： | 5 |
| 2 | Application of two-dimensional near-infrared correlation spectroscopy to the discrimination of Chinese herbal medicine of different geographic regions显示文摘 | Jun Lu Bingren Xiang Hao Liu Suyun Xiang Shaofei Xie Haishan Deng | 2007 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2007，，2： | 1 |
| 3 | Cath-KP,a novel peptide derived from frog skin,prevents oxidative stress damage in a Parkinson’s disease model显示文摘Parkinson’s disease(PD)is a neurodegenerative condition that results in dyskinesia,with oxidative stress playing a pivotal role in its progression.Antioxidant peptides may thus present therapeutic potential for PD.In this study,a novel cathelicidin peptide(Cath-KP;GCSGRFCNLF NNRRPGRLTLIHRPGGDKRTSTGLIYV)was identified from the skin of the Asiatic painted frog(Kaloula pulchra).Structural analysis using circular dichroism and homology modeling revealed a uniqueαββconformation for Cath-KP.In vitro experiments,including free radical scavenging and ferric-reducing antioxidant analyses,confirmed its antioxidant properties.Using the 1-methyl-4-phenylpyridinium ion(MPP^(+))-induced dopamine cell line and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,Cath-KP was found to penetrate cells and reach deep brain tissues,resulting in improved MPP^(+)-induced cell viability and reduced oxidative stress-induced damage by promoting antioxidant enzyme expression and alleviating mitochondrial and intracellular reactive oxygen species accumulation through Sirtuin-1(Sirt1)/Nuclear factor erythroid 2-related factor 2(Nrf2)pathway activation.Both focal adhesion kinase(FAK)and p38 were also identified as regulatory elements.In the MPTP-induced PD mice,Cath-KP administration increased the number of tyrosine hydroxylase(TH)-positive neurons,restored TH content,and ameliorated dyskinesia.To the best of our knowledge,this study is the first to report on a cathelicidin peptide demonstrating potent antioxidant and neuroprotective properties in a PD model by targeting oxidative stress.These findings expand the known functions of cathelicidins,and hold promise for the development of therapeutic agents for PD. | Huanpeng Lu Jinwei Chai Zijian Xu Jiena Wu Songzhe He Hang Liao Peng Huang Xiaowen Huang Xi Chen Haishan Jiang Shaogang Qu Xueqing Xu | 2024 | Zoological Research2024，45，1： | 0 |
| 4 | Experimental Study of the Effect of the Bax Gene on Human Hepatocellular Carcinoma and Therapy via Hepatic Artery Delivery显示文摘 | Zhi Guo Wenge Xing Haishan Yang Lin Wang Yunpeng Jiang Bingyu Huang Gong Nu Yan Lu | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 0 |
| 5 | An Improved Graphics Processing Unit Acceleration Approach for Three-Dimensional Structural Topology Optimization Using the Element-Free Galerkin Method显示文摘We proposed an improved graphics processing unit(GPU)acceleration approach for three-dimensional structural topology optimization using the element-free Galerkin(EFG)method.This method can effectively eliminate the race condition under parallelization.We established a structural topology optimization model by combining the EFG method and the solid isotropic microstructures with penalization model.We explored the GPU parallel algorithm of assembling stiffness matrix,solving discrete equation,analyzing sensitivity,and updating design variables in detail.We also proposed a node pair-wise method for assembling the stiffnessmatrix and a node-wise method for sensitivity analysis to eliminate race conditions during the parallelization.Furthermore,we investigated the effects of the thread block size,the number of degrees of freedom,and the convergence error of preconditioned conjugate gradient(PCG)on GPU computing performance.Finally,the results of the three numerical examples demonstrated the validity of the proposed approach and showed the significant acceleration of structural topology optimization.To save the cost of optimization calculation,we proposed the appropriate thread block size and the convergence error of the PCG method. | Haishan Lu Shuguang Gong Jianping Zhang Guilan Xie Shuohui Yin | 2021 | Computer Modeling in Engineering & Sciences2021，，9： | 0 |
| 6 | The isomorphic realization of nondegenerate solvable Lie algebras of maximal rank based on Kac-Moody algebras显示文摘In this paper,based on Kac-Moody algebra,the isomorphic realization of nondegenerate solvable Lie algebras of maximal rank is given,which in turn revels the closed connections between nondegenerate solvable Lie algebras and Kac-Moody algebras,resulting in some new worthy topics in this area. | LU CaiHui ZHANG HaiShan | 2013 | Science China Mathematics2013，56，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员