|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Biotechnological approaches in glucosinolate production显示文摘Glucosinolates(GLSs) are sulfur-rich, amino acid-derived defense compounds characteristic of the Brassicales order. In the past, GLSs were mostly known as anti-nutritional factors in fodder, biopesticides in agriculture, and flavors in condiments such as mustard. However, in recent times, GLSs have received increased attention as promoters of human health.This has spurred intensive research towards generating rich sources of health-promoting GLSs. We provide a comprehensive overview of the biotechnologica approaches applied to reach this goal. This includes optimization of GLS production and composition in native, GLS-producing plants, including hairy root and cell cultures thereof, as well as synthetic biology approaches in heterologous hosts, such as tobacco and the microbial organisms Escherichia coli and Saccharomyces cerevisiae. The progress using these different approaches is discussed. | Annette Petersen Cuiwei Wang Christoph Crocoll Barbara Ann Halkier | 2018 | Journal of Integrative Plant Biology2018，60，12： | 6 |
| 2 | The Glucosinolate Biosynthetic Gene A OP2 Mediates Feed-back Regulation of Jasmonic Acid Signaling in Arabidopsis显示文摘在改变并且质问环境的幸存要求一个有机体高效地获得并且使用它的资源。由于他们的无柄的性质,植物动态地优化他们的新陈代谢是特别地批评的。在植物主要新陈代谢,新陈代谢的调整包含一条小径的输出控制它的输入产生精确、柔韧的回答到环境变化的反馈机制。由对比,很少研究为第二等的新陈代谢的反馈规定探讨了潜力。在 Arabidopsis,防卫混合物 glucosinolates 的累积以前在 glucosinolate biosynthetic 基因 AOP2 被连接了到基因变化。AOP2 表示能增加小径的二个已知的管理者(MYB28 和 MYB29 ) 的抄本层次,建议 AOP2 起在控制 glucosinolate 生合成的积极反馈规定的一个作用。我们产生了影响 AOP2, MYB28/29,或两个的异种。这些异种的 Transcriptome 分析识别了在表明 MYB28 和 MYB29 的独立人士的 AOP2 和 jasmonic 酸(JA ) 之间的一个到目前为止未被认出的连接。因此, AOP2 是连接 glucosinolate 生合成并且 JA 发信号的一个规章的反馈环的部分并且从而允许 glucosinolate 小径影响 JA 敏感。这个规章的反馈环的发现提供植物怎么为防御代谢物优化资源的使用的卓见。 | Meike Burow Susanna Atwell Marta Francisco Rachel E. Kerwin Barbara A. Halkier Daniel J. Kliebenstein | 2015 | Molecular Plant2015，8，8： | 6 |
| 3 | Production of the Cancer-Preventive Glucoraphanin in Tobacco显示文摘流行病学的研究表明了在饰有十字架的蔬菜在食谱富人的消费之上得癌症的减少的风险。这 chemoprevention 大部分被归因于自然产品 glucosinolates 的存在,特别地从花椰菜的导出蛋氨酸的 glucoraphanin。由功能的食物或支持健康的饮食的补充的改进营养是为基于生活方式的疾病的预防的一个吸引人的工具。向这个目标,我们设计了 glucoraphanin 小径进烟草。首先,我们设计了蛋氨酸的方面链的延伸生产关键中间的 dihomo 蛋氨酸。这个过程在在叶绿体在 cytosol 并且部分部分发生的一条链延伸小径通过二个周期被催化。由联合链延伸小径的五酶到 glucosinolate 小径的八酶,第二,我们证明和另外的 glucosinolates 的 glucoraphanin 的生产源于伸长链的异白氨酸或白氨酸。到 glucoraphanin 的蛋氨酸的变换经由 14 中介被获得。在一位 heterologous 主人表明高值的 glucoraphanin 的生产作为一个工具有在食物和药用的工业的大潜力为人的健康的利益产生 glucoraphanin 的稳定的、富有的来源。 | Michael Dalgaard Mikkelsen Carl Erik Olsen Barbara Ann Halkier | 2010 | Molecular Plant2010，3，4： | 3 |
| 4 | BIOLOGY AND BIOCHEMISTRY OF GLUCOSINOLATES显示文摘 | Barbara Ann Halkier Jonathan Gershenzon | 2006 | Annual Review of Plant Biology2006，，： | 2 |
| 5 | Catalytic reactivities and structure/function rela- tionships of cytochrome P450 enzymes 显示文摘 | Halkier B A | 1996 | Phytochemistry1996，43，1： | 1 |
| 6 | Biochemical networks and epistasis shape the Arabidopsis thaliana metabolome显示文摘 | Rowe H C Hansen B G Halkier B A | 2008 | Plant Cell2008，20，5： | 1 |
| 7 | Biology and Biochemistry of Glueosinolates 显示文摘 | HALKIER B A GERSHENZON J | 2006 | Annu Rev Plant Biol2006，57，： | 1 |
| 8 | Altering Glucosinolate Profiles Modulates Disease Resistance in Plants 显示文摘 | BRADER G MIKKELSEN M D HALKIER B A | 2006 | The Plant Journal2006，46，5： | 1 |
| 9 | Biology and bio- chemistry of glucosinolates 显示文摘 | HALKIER B A GERSHENZON J | 2006 | Annual Review of Plant Biology2006，57，1： | 1 |
| 10 | Functional expression and characterization of the myrosinase MYR1 from Brassica napus in Saccharomyces cerevisiae 显示文摘 | CHEN S HALKIER B A | 1999 | Protein Expr Purif1999，17，： | 1 |
| 11 | Biology and biochemistry of glucosinolates 显示文摘 | Halkier B A Gershenzon J | 2006 | Annual Review of Plant Biology2006，57，： | 1 |
| 12 | Identifying the molecular basis of QTLs: eQTLs add a new dimension显示文摘 | Hansen B G Halkier B A Kliebenstein D J | 2008 | Trends in Plant Science2008，13，2： | 1 |
| 13 | CCSDT calculations of molecular equilibrium geometries显示文摘 | Halkier A Jφrgensen P Jurgen G | 1997 | Chem Phys Lett1997，274，： | 1 |
| 14 | Innovation and Destination Governance in Denmark:Tourism,Policy Networks and Spatial Development显示文摘 | Halkier Henrik | 2013 | European Planning Studies2013，，8： | 1 |
| 15 | Biosyn- thesis of glucosinolates gene discovery and beyond显示文摘 | SONDERBY I E GEU-FLORES F HALKIER B A | 2010 | Trends in Plant Science2010，15，5： | 1 |
| 16 | Substrate specificity of the cytochrome P450 enzymes CYP79A1 and CYP71E1 involved in the biosynthesis of the cyanogenlc glucoside dhurrin in Sorghum bicolor ( L ) Moench 显示文摘 | Kahn R A Fahrendorf T Halkier B A | 1999 | Arch Biochem Biophys1999，363，1： | 1 |
| 17 | Non-volatile intact indole glucosinolates are host recognition cues for ovl- positing Plutella xylostella显示文摘 | SUN J Y SONDERBY I E HALKIER B A | 2009 | Journal of Chemical Ecology2009，35，12： | 1 |
| 18 | Biosynthesis of glueoslnolates-gene discovery and beyond 显示文摘 | Sφnderby I E Geu-Flores F Halkier B A | 2010 | Trends in Plant Science2010，15，5： | 1 |
| 19 | Effects of increased dietary protein - to - carbohydrate ratios in women with polyeystie ovary syn- drome 显示文摘 | Srecnsen LB See M Halkier KH | 2012 | AmJClinNutr2012，95，1： | 1 |
| 20 | Glucosinolate research in the Arabidopsis era 显示文摘 | Wittstock U Halkier B A | 2002 | Trends in Plant Science2002，7，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员