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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | DynamicYoung's modulus and dimensional stability of Batai tropical wood impregnated with polyvinyl alcohol显示文摘 | ISLAM M S HAMDAN S RAHMAN M R | 2010 | Journal of Scientific Research2010，2，2： | 1 |
| 3 | Endovascular stents for coarctation of the aorta: initial results and inter- mediate term follow-up显示文摘 | Hamdan MA Maheshwarl S Fahey JT | 2001 | J Am Coil Cardiol2001，38，： | 1 |
| 4 | Coupling of the home and an internal disulfide bond in human neuroglobin 显示文摘 | Hamdane D Kiger L Dewilde S | 2004 | Micron2004，35，1： | 1 |
| 5 | Stability of vertically bent pipelines buried insand 显示文摘 | Sahel N A Hamdan N A Junaid A S Ibrahim M A Naser A A | 2004 | Journal of Pressure Vessel Technology Transactions of the ASME2004，126，3： | 1 |
| 6 | Endovascular stents for coarctation of the aorta:initial results and intermediate term follow-up显示文摘 | Hamdan MA Maheshwari S Fahey JT | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 7 | Degradation of D,L-2-chloropropionic acid by bacterial dehalogenases that shows stereospecificity and its partial enzymatic characteristics显示文摘 | Thasif S Hamdan S Huyop F | 2009 | Biotechnology2009，8，2： | 1 |
| 8 | The Redox state of thecell regulates the ligand binding affinity of human neuro-globin and cytoglobin显示文摘 | Hamdane D Kiger L Dewilde S | 2003 | J Biol Chem2003，278，51： | 1 |
| 9 | Mo-lecular epidemiology of Cryptoeoecus neoformans in Bra-zil and the United States:evidence for both local genetic differences and a global clonal population structure 显示文摘 | FRANZOT S P HAMDAN J S CURRIE B P | 1997 | Journal of clinical microbiology1997，35，9： | 1 |
| 10 | Endovascular stents for coarctation of the aorta:initial results and intermediate-term follow-up显示文摘 | Maheshwari S Fahey JT | 2001 | J Am Coll Cardiol2001，38，5： | 1 |
| 11 | The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin显示文摘 | Hamdane L Kiger S Dewilde BN | 2003 | J Biol Chem2003，278，51： | 1 |
| 12 | Platelet-poor plasma stimulates the proliferation but inhibits the differentiation of rat osteoblastic cells in vitro 显示文摘 | HAMDAN A A LOTY S ISAAC J | 2009 | Clin Oral Implants Res2009，20，6： | 1 |
| 13 | Hydrothermal scheduling based Lagrangian relaxation approach to hydrothermal coordination显示文摘 | Salam M S Nor K M Hamdan A R | 1998 | IEEE Transactions on Power Systems1998，13，1： | 1 |
| 14 | A mutant L-asparagi- nase II signal peptide improves the secretion of recombinant cyclodextrin glucanotransferase and the viability of Escherichia coli 显示文摘 | ISMAIL N F HAMDAN S MAHADI N M | 2011 | Bioteehnol Lett2011，33，： | 1 |
| 15 | Platelet-poor plasma stimulates the proliferation but inhibits the differentiation of ratosteoblastic cells in vitro 显示文摘 | Hamdan AA Loty S Isaac J | 2009 | Clin Oral Implants Res2009，20，6： | 1 |
| 16 | Platelet-poor plasma stimulates the proliferation but inhibits the differentiation of rat osteoblastic cells in vitro显示文摘 | Hamdan AA Loty S Isaac J | 2009 | Clin Oral Implants Res2009，20，6： | 1 |
| 17 | cAMP-re- sponse element (CRE) - mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian ex- pression of the Period2 gene显示文摘 | Koyanagi S Hamdan A M Horiguehi M | 2011 | J Biol Chem2011，286，32： | 1 |
| 18 | Nickel subsulfide is similar to potassium dichromate in protecting normal human fibroblasts from the mutagenic effects of benzopyrene diolepoxide显示文摘 | Hamdan S Morse B Reinhold D | 1999 | Environl & Mol Mutagen1999，33，3： | 1 |
| 19 | Variation of endothelial nitric oxide synthase synthesis in the median eminence during the rat estrous cycle: an additional argument for the implication of vascular blood vessel in the control of GnRH release显示文摘 | Ferreira S Hamdane M Mailliot C Prevot V Beauvillain JC | 2001 | Endocrinology2001，142，10： | 1 |
| 20 | Interaction of beta 2- glycoprotein 1 with phosphatidylserine-containing membranes : Ligand-dependent conformational alterations initiate bivalent binding显示文摘 | Hamdan R Maiti S N Schroit A J | 2007 | Biochemistry2007，46，10： | 1 |
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