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| 1 | Protective effects of estrogens and caloric restriction during aging on various rat testis parameters显示文摘瞄准:调查 17 β-estradiol (E2 ) 的效果, Peganum 伤害翼摘录(PHE ) 和各种各样的睾丸参数上的热量的限制(CR ) 在老化期间。方法:Twelve-month-old 雄的老鼠与 E2 或 PHE 被对待 6 个月,或提交了到 CR (40%) 。结果:我们的结果证明雌激素和 CR 能由象 aromatase 和雌激素受体基因表情的减少一样阻止睾丸激素和 E2 层次的减少保护男性腺。确实, E2, PHE 和 CR 处理在超级氧化物 dismutase 活动导致了增加并且减少阴囊的酶的活动:gamma-glutamyl transferase,碱的磷酸酶,喂奶 deshydrogenase 以及 aspartate 并且喂奶在年老的动物的 transaminases。另外,阴囊的过氧化氢酶和 gluthatione peroxidase 活动在 18 月年龄与未经治疗的动物相比在 E2, PHE 和对待 CR 的老鼠被提高。而且, estradiol, PHE 和 CR 的积极效果被类脂化合物的底层进一步每氧化支持。精子发生的恢复在对待的老鼠被记录。结论:除为精子发生有益的一本低热量的食谱以外,雌激素的一个保护的 antioxydant 角色被建议。雌激素推迟阴囊的房间损坏,它导致功能的老朽并且,因此雌激素在保护繁殖功能免受在年老的睾丸在大数量生产的反应的氧种类(ROS ) 施加的不利效果的伤害是有用的。 | Khaled Hamden Dorothee Silandre Christelle Delalande Abdelfattah E1Feki Serge Carreau | 2008 | Asian Journal of Andrology2008，10，6： | 5 |
| 2 | Age-related decrease in aromatase and estrogen receptor (ERα and ERβ) expression in rat testes: protective effect of low caloric diets显示文摘瞄准:在身体上并且在阴囊的重量上在热量的限制( CR1 )并且在营养( CR2 )下面的老鼠老化上检验效果在二种酶的抗氧化剂(超级氧化物 dismutase 和过氧化氢酶)上,在类脂化合物上每氧化并且在阴囊的 aromatase 和雌激素受体的表示上(嗯)。方法:CR 在 1-month-old 老鼠被开始并且继续直到 18 个月的年龄。结果:在控制和 CR2 老鼠 aromatase 并且的年龄相关的减少嗯(α
和 β
) 基因表示被观察;在平行,阴囊的重量,并且 epididymal spermatozo 的全部的数字和活动性的减少被记录。另外,在控制和 CR2 老鼠变老被重要减少每氧化水平在阴囊的超级氧化物 dismutase,过氧化氢酶活动,和类脂化合物的增加伴随(thiobarbituric 酸反应物质) ,与精子发生的改变联系了。相反地,热量的限制处理施加了保护的效果,所有参数是老化影响的更少。结论:这些结果在老化期间显示那,一本低热量的食谱(不在营养下面) 为精子发生是有益的并且多半经由 aromatase/ER 能在起一个作用的细胞的抗氧化剂防卫系统的增加改进房间的保护。 | Khaled Hamden Dorothee Silandre Christelle Delalande Abdefattah El Feki Serge Carreau | 2008 | Asian Journal of Andrology2008，10，2： | 2 |
| 3 | Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats显示文摘 | Soussi Ahlem Hamden Khaled Marouane Wafa Bezzine Sofiane Damak Mohamed Murat Jean-Claude El Feki Abdelfattah | 2009 | Chemico-Biological Interactions2009，，1： | 2 |
| 4 | Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats显示文摘 | Hamden K Allouche N Damak M | 2009 | Chem Biol Interact2009，180，3： | 1 |
| 5 | Expression of cytokeratin 20 redefines urothlial papillomas of the bladder 显示文摘 | Hamden P Mabinood N Southgate J | 1999 | Lancet1999，353，： | 1 |
| 6 | Identification of the cerebra loci professing human swallowing with H2150 PET aerie aviation 显示文摘 | Hamden S Roth well JC Brookes DJ | 1999 | Neuron1999，81，： | 1 |
| 7 | Inhibitory effect of fenugreek galatomannan on dig-estive enzymes related to diabetes,hyperlipidemia,and liver-kidney dysfunctions显示文摘 | Hamden K Jaouadi B Carreau S | | 0，，： | 1 |
| 8 | Modulatory effect of fenugreek saponins on the activities of intestinal and hepatic disaccharidase and glycogen and liver function of diabetic rata显示文摘 | Hamden K Jaouadi B SalamiT | | 0，，： | 1 |
| 9 | Inhibitory Effect of Estrogens,Phytoestrogens,and Caloric Restriction on Oxidative Stress and Hepato-toxicity in Aged Rats显示文摘Objective To investigate the protective effect of 17β-estradiol (E2), peganum harmala extract (PHE) administration and calorie restriction (CR) treatment (60%) on oxidative stress and hepato-toxicity in aged rats. Methods Eighteen months old animals that were treated at the age of 12 months were divided into 4 groups: normal control group with free access to food, E2 treatment group, PHE treatment group and CR treatment group of the food given to control group. Six male rats at the age of 4 months were used as a reference group. Results Aging significantly decreased superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and increased lactate deshydrogenase (LDH), gamma-glytamyl transferase (GGT), phosphatase alkalines (PAL), aspartate and lactate transaminase (AST and ALT) activities in the liver. Aging also induced an increased lipid peroxidation level, histological changes and a decreased E2 level. However, treatment with E2, PHE, and CR increased 17β-estradiol, and decreased hepatic dysfunction parameters and lipid peroxidation as well as histological changes in the liver of aged rats. Conclusion The antioxidant and hepatoprotective activity of PHE and CR is possibly attributed to its ability to increase E2 level, which as an antioxidant, acts as a scavenger of ROS. Further studies on the pharmaceutical functions of E2 in males may contribute to its clinical application. | KHALED HAMDEN SERGE CARREAU FATMA AYADI HATEM MASMOUDI ABDELFATTAH EL FEKI | 2009 | Biomedical and Environmental Sciences2009，22，5： | 1 |
| 10 | Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats 显示文摘 | Hamden K Jaouadi B Zara N | 2011 | J Physiol Biochem2011，67，1： | 1 |
| 11 | Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats显示文摘 | Hamden K Allouche N Damak M | 2009 | Chem Biol Interact2009，180，3： | 1 |
| 12 | Neuraminidase inhibitors for preventing and treating influenza in children显示文摘 | Matheson NJ Hamden AR Perera R | 2007 | Cochrane Database Syst Rev2007，24，00： | 1 |
| 13 | Antidiabetic activity of levan polysaceharide in alloxan-induced diabetic rats 显示文摘 | Dahech I Belghith KS Hamden K | 2011 | Int J Biol Macromol2011，49，： | 1 |
| 14 | Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats显示文摘 | Dahech I Belghith KS Hamden K | 2011 | Int J Biol Macromol2011，49，4： | 1 |
| 15 | lAlpha,25 dihydroxyvitamin D3: therapeutic and preventive effects against oxidative stress,hepatic,pan- creatic and renal injury in alloxan-induced diabetes in rats显示文摘 | Hamden K Carreau S Jamoussi K | 2009 | Nutr Sci Vitaminol (Tokyo)2009，55，3： | 1 |
| 16 | Expression of cytokeratin 20 redefines urothelial papillomas of the bladder 显示文摘 | Hamden P Mahmood N Southgate J | 1999 | Lancet1999，353，： | 1 |
| 17 | Organ localization of auxin-binding protein 1 in the etiolated maize seedling显示文摘 | Hamden D Jones A M | 1995 | Journal of Plant Growth regulation1995，14，： | 1 |
| 18 | Key clinical issues in renalcancer: a challenge for proteomics显示文摘 | Banks RE Craven RA Hamden P | 2007 | World J Urol2007，25，6： | 1 |
| 19 | Inhibition of keydigestive enzymes related to diabetes and hyperlipidemiaand protection of liver-kidney functions by trigonelline indiabetic rats显示文摘 | Hamden K Mnafgui K Amri Z | 2013 | Sci Pharm2013，1210，19： | 1 |
| 20 | Kawasaki disease:what is the epi- demiology telling us about the etiology 显示文摘 | Burguer D Hamden A | 2005 | Int J Infect Dis2005，9，4： | 1 |
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