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| 1 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 2 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 3 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 4 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 5 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois K A Gilles J K Hamilton P A | 1956 | Anal Chem1956，28，3： | 1 |
| 6 | Use of a ramp velocity test to measure critical swimming speed in Rainbow trout (Oncorhynchus mykiss) 显示文摘 | Jain K E Hamilton J C Farrell A P | 1997 | Comparative Biochemistry Physiology1997，117，： | 1 |
| 7 | Colorimetric methods for determination of sugars and related substances 显示文摘 | DOBOIS M A HAMILTON J K REBERS P A | 1956 | Analytical Chemistry1956，28，3： | 1 |
| 8 | Trace metal profiles in the varved sediment of an Arctic lake显示文摘 | Outridge P M Stern G A Hamilton P B | 2005 | Geochim Cosmochim Acta2005，69，20： | 1 |
| 9 | Prediction of ra- diated noise from machine components using the BEM and the ray- leigh integral 显示文摘 | SEYBERT A F HAMILTON D A HAYES P A | 1998 | Noise Control Engineering Journal1998，46，3： | 1 |
| 10 | Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks显示文摘 | QURESHI M A BRAKE J HAMILTON P B | 1998 | Poultry Science1998，77，6： | 1 |
| 11 | Trace metal profiles in the varied sediment of an Arctic lake 显示文摘 | Outridge P M Stem G A Hamilton P B | 2005 | Geochimica et Cosmochimica Acta2005，69，20： | 1 |
| 12 | Modelling the relative importance of internal and external nutrient loads on water column nutrient concentrations and phytoplankton biomass in a shallow polymictic lake 显示文摘 | Burger D F Hamilton D P Pilditch C A | 2008 | Ecological Modelling2008，211，： | 1 |
| 13 | Synthesis of polyacrylamide nanogels by intramolecular disulfide cross-linking 显示文摘 | Aliyar H A Hamilton P D Remsen E E | 2005 | Journal of Bioactive and Compatible Polymers2005，20，2： | 1 |
| 14 | Reconstructing the Primordial Spectrmn of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 1 |
| 15 | Regulation Of CD8^+T cells under going primaryand secondary responses to infection in the same host显示文摘 | Badovinac V P Messingham K A Hamilton S E | 2003 | Immunol2003，170，： | 1 |
| 16 | Mapping diagenetic fluid flow within a reservoir:K-Ar dating in the alwyn area (UK north sea)显示文摘 | HOGG A J C HAMILTON P J MACINTYRE R M | 1993 | Marine and Petroleum Geology1993，，10： | 1 |
| 17 | Effect of Water Exchange Rate on Production, Water Quality, Effluent Characteristics and Nitrogen Budgets of Intensive Shrimp Ponds 显示文摘 | Hopkins J S Hamilton R D Sandifer P A | 1993 | J World Aquac Soc1993，24，： | 1 |
| 18 | Oxygen in the Cupola: A Comparison of Enrichment versus Direct Injection 显示文摘 | Trammell P G and Hamilton J A | 1981 | AFS Transactions1981，81，： | 1 |
| 19 | Dietary exposure of broiler breeders to aflatoxin results in immune dysfunction in progeny chicks 显示文摘 | Qureshi M A Brake J Hamilton P B | 1998 | Pouhy Science1998，77，6： | 1 |
| 20 | Benthic nutrient fluxes in a eutroph- ic, polymictic lake显示文摘 | Burger D F Hamilton D P Pilditch C A | 2007 | Hydrobiologia2007，584，： | 1 |
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