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| 1 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 2 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B | 1979 | Geoehim Cosmoehim Acta1979，43，7： | 1 |
| 3 | Intermittent oral ZD1839(Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI), shows evidence of good tolerability and activity:Final results from a phase I study显示文摘 | Ferry D Hammond L Ranson M | 2000 | Proc Am Soc Clin Oncol2000，19，： | 1 |
| 4 | ZD1839, a selective oral epidermal growth factor receptor- tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial 显示文摘 | Ranson M Hammond L A Ferry D | 2002 | J Clin Onco2002，20，9： | 1 |
| 5 | Making supply meet demand in an uncertainty world显示文摘 | Fisher M L Hammond J H Obermeyer W R | 1994 | Harvard Business Review1994，72，3： | 1 |
| 6 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B Maynard V | 1979 | Geochim Cosmochim Acta1979，43，7： | 1 |
| 7 | Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron显示文摘 | HAMMOND K E METCALF M CARVAJAL L | 2008 | Ann Neurol2008，64，70： | 1 |
| 8 | ZD1839,a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor,is well tolerated and active in patients with solid,malignant tumors:results of a phase I trial 显示文摘 | Ranson M Hammond L A Ferry D | 2002 | J Clin Oncol2002，20，： | 1 |
| 9 | The Stanford Hydra CMP显示文摘 | Hammond L Hubbert B Siu M | 2000 | IEEE Micro Magazine2000，20，2： | 1 |
| 10 | Role of spinal gamma-aminobu-tyric acid A receptors in formalin-induced nociception in therat显示文摘 | Kaneko M Hammond D L | 1997 | J Pharmacol Exp Ther1997，282，2： | 1 |
| 11 | Making supply meet demand in an uncertain world 显示文摘 | Fisher M L Hammond J H Oberrneyer W R | 1994 | Harvard Business Review(May-June)1994，，： | 1 |
| 12 | Selective deposition in multilayer assembly:SAMs as molecular templates显示文摘 | Clark S L Montague M Hammond P T | 1997 | Supramolecular Science1997，4，12： | 1 |
| 13 | Policies that Support Professional Development in an Era of School Reform 显示文摘 | Darling- Hammond L McLaughlin M W | 1995 | Phi Delta Kappan1995，76，8： | 1 |
| 14 | Antifungal lipopeptides: structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives显示文摘 | Zambias R A James C Hammond M L | 1995 | Bioorg & Med Chem Lett1995，5，20： | 1 |
| 15 | Selective decontamination of the digestive tract in multiple trauma patients: Is there a role? Results of a prospective, double-blind, randomized trial 显示文摘 | HAMMOND J M J POTGIETR P D SAUNDER G L | 1994 | CritCare Med1994，22，： | 1 |
| 16 | Two-step laser mass spectrometry of asphaltenes显示文摘 | POMERANTZ A E HAMMOND M R MORROW A L | 2008 | J Am Chem Soc2008，130，： | 1 |
| 17 | Asphaltene molecular-mass distribution determined by two-step laser mass speetrometry显示文摘 | POMERANTZ A E HAMMOND M R MORROW A L | 2009 | Energy Fuels2009，23，3： | 1 |
| 18 | O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation显示文摘 | Raineri M Catalano M G Hammond G L | 2002 | Mol Cell Endocrinol2002，189，12： | 1 |
| 19 | The stanford hydra CMP显示文摘 | Hammond L Hubbert B Siu M etal | 2000 | IEEE Micro2000，20，2： | 1 |
| 20 | Recommen- dations for validating estrogen and progesterone receptor immuno- histochemistry assays 显示文摘 | Fitzgibbons P L Murphy D A Hammond M E | 2010 | Arch Pathol Lab Med2010，134，6： | 1 |
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