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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Risk and predictors for pregnancy-related complications in women with heart disease显示文摘 | Siu SC Sermer M Harrison DA | 1997 | Circulation1997，96，： | 1 |
| 4 | Phase I and phar-macologic study of OSI -774, an epidermal growth factor receptor tyrosine kinase inibitor, in patients with advanced solid malignancies显示文摘 | Hidalgo M Siu LL Nemunaitis J | 2001 | J Clin Oncol2001，19，： | 1 |
| 5 | Molecular regulation of apoptosis in fast plantaris muscles of aged rats 显示文摘 | Pistilli E E Siu P M Alway S E | 2006 | Gerontol A Biol Sci Med Sci2006，61，3： | 1 |
| 6 | Sympathetic storming in a patient with intracranial basal ganglia hemorrhage显示文摘 | Siu G Marino M Desai A | 2011 | Am J Phys Med Rehabil2011，90，3： | 1 |
| 7 | A survey of the malonaldehyde content of retail meats and fish显示文摘 | SIU G M DRAPER H | 1978 | Journal of Food Science1978，43，： | 1 |
| 8 | An effective Low Bit-Rate Video Coding Algorithm Focusing on Moving regions 显示文摘 | Wong K W Lam K M Siu W C | 2001 | IEEE Trans circuits and systems for video technology2001，11，10： | 1 |
| 9 | Controlled microfluidic encapsulation of cells, proteins, and microbeads in lipid vesicles 显示文摘 | Tan YC Hettiarachchi K Siu M | 2006 | JAm Chem Soc2006，128，17： | 1 |
| 10 | Dose and schedule-duration escalation of epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor CP-358774:a phase I and pharmacokinetic (PK) study显示文摘 | Siu L L Hidalgo M Nemunaitis J ed al | 1999 | Proc Am Soc Clin Oncol1999，18，： | 1 |
| 11 | Risk and predictors forpregnancy-related complications in women with heart disease 显示文摘 | Siu S C Sermer M Harrison D A | 1997 | Circulation1997，96，9： | 1 |
| 12 | The influence of visual perception of self-motion on locomotor adaptation to unilateral limb loading显示文摘 | Mukherjee M Siu KC Katsavelis D | 2011 | J Mot Behav2011，43，2： | 1 |
| 13 | Integration of acoustic and articulatory information with application to speech recognition显示文摘 | Leung K Y Siu M H | 2004 | Information Fusion2004，5，2： | 1 |
| 14 | Tolerability of the Intergroup 0099 (INT 0099 ) regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status 显示文摘 | BAHL M SIU L L POND G R | 2004 | Int J Radiat Oncol Biol Phys2004，60，8： | 1 |
| 15 | A low complexity selected mapping scheme by use of time domain se-quence superposition technique for PAPR reduction in OFDM system显示文摘 | YANG L SOO K K SIU Y M | 2008 | IEEE Transactions on Broadcast-ing2008，54，4： | 1 |
| 16 | Role of NCAM,cadherins,and microfilaments in cell-cell contact formation in TM4 immature mouse sertoli cells显示文摘 | SANDIG M KALNINS V I SIU C H | 1997 | Cell Motil Cytoskeleton1997，36，2： | 1 |
| 17 | Response of caspase-independent apoptotic factors to high salt diet-induced heart failure显示文摘 | Siu P M Bae S Bodyak N | 2007 | J Mol Cell Cardiol2007，42，3： | 1 |
| 18 | Line - heat - source guarded - hot - plate apparatus 显示文摘 | Siu M C I Bulik C | 1981 | Review of Scientific Instruments1981，52，11： | 1 |
| 19 | Age-dependent in- crease in oxidative stress in gastrocnemius muscle with unloa- ding显示文摘 | SIU P M PISTILLI E E ALWAYS S E | 2008 | J Appl Physiol2008，105，6： | 1 |
| 20 | Prospective muhicenter study of pregnancy outcomes in women with heart diseasef显示文摘 | Siu SC Sermer M Colman JM | 2001 | Circulation2001，104，： | 1 |
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