| 1 | Active Fault Exploration and Seismic Hazard Assessment in Fuzhou City显示文摘It has been proven by a number of earthquake case studies that an active fault-induced earthquake beneath a city can be devastating. It is an urgent issue for seismic hazard reduction to explore the distribution of active faults beneath the urban area and identify the seismic source and the risks underneath. As a pilot project of active fault exploration in China, the project, entitled “Active fault exploration and seismic hazard assessment in Fuzhou City', started in early 2001 and passed the check before acceptance of China Earthquake Administration in August 2004. The project was aimed to solve a series of scientific issues such as fault location, dating, movement nature, deep settings, seismic risk and hazard, preparedness of earthquake prevention and disaster reduction, and etc. by means of exploration and assessment of active faults by stages, i.e., the preliminary survey and identification of active faults in target area, the exploration of deep seismotectonic settings, the risk evaluation of active seismogenic faults, the construction of geographic information system of active faults, and so on. A lot of exploration methods were employed in the project such as the detection of absorbed mercury, free mercury and radon in soil, the geological radar, multi-channel DC electrical method, tsansient electromagnetic method, shallow seismic refraction and reflection, effect contrast of explored sources, and various sounding experiments, to establish the buried Quaternary standard section of the Fuzhou basin. By summing up, the above explorations and experiments have achieved the following results and conclusions: (1)The results of the synthetic pilot project of active fault exploration in Fuzhou City demonstrate that, on the basis of sufficient collection, sorting out and analysis of geological, geophysical and borehole data, the best method for active fault exploration (location) and seismic risk assessment (dating and characterizing) in urban area is the combination of various approaches, that is, the possible location of active fault determined by using geochemical exploration as a guide “scout', the shallow seismic sounding as the main tool, the electromagnetic method as a supplement, establishing the standard Quaternary profile or stratigraphic sequence from drilling and various geophysical parameters from borehole logs as methods to correct and verify the data above. And in addition, the method also includes the field surveys on fault exposures, trenching, paleoearthquake investigation, dating and comparison of lithology, strata sequence, absolute or relative ages of the cores on the two sides of buried faults. (2)The Fuzhou basin locates under the regional seismotectonic settings which have the potential of moderate earthquake. Comparatively, the region is less affected by the “Taiwan dynamic Antenna'; (3)The activity of the major faults in Fuzhou basin is weak in general. All the six identified target faults are not Holocene faults, among which the Bayi Reservoir-Shanggan fault and the Minhou-Nanyu fault are dormant at least since the mid Epipleistocene time, and the rest are dormant since the Epipleistocene time; (4)In terms of deep-seated structures beneath the basin, there is no evidence indicating the possible occurrence of the underneath strong destructive earthquakes. The adjacent Changle-Zhao’an fault zone is the potential seismic source which may possibly affect Fuzhou City; (5)There exists potential of moderate-strong earthquake on the major faults of the region, but the probability is low; (6)The seismic hazards are weak in the region and the surface earthquake fractures are not likely to occur; (7)The first geographic information system of active faults is developed with functions of information query and display, data management, analysis and processing, etc. | Zhu Jinfang Huang Zonglin Xu Xiwei Zheng Rongzhang Fang Shengmin Bai Denghai Wang Guangcai Min Wei Wen Xueze Han Zhujun | 2005 | Earthquake Research in China2005，19，3： | 7 |
| 4 | Developing the QSPR model for predicting the storage lipid/water distribution coefficient of organic compounds显示文摘The distribution of organic compounds in stored lipids affects their migration,transformation,bioaccumulation,and toxicity in organisms.The storage lipid/water distribution coefficient(log K_(lip/w))of organic chemicals,which quantitatively determines such distribution,has become a key parameter to assist their ecological security and health risk.Due to the impossibility to measure K_(lip/w)values for a huge amount of chemicals,it is necessary to develop predictive approaches.In this work,a quantitative structure-property relationship(QSPR)model for estimating log K_(lip/w)values of small organic compounds was constructed based on 305 experimental log K_(lip/w)values.Quantum chemical descriptors and n-octanol/water partitioning coefficient were employed to characterize the intermolecular interactions that dominate log K_(lip/w)values.The hydrophobic and electrostatic interactions and molecular size have been found to play important roles in governing the distribution of chemicals between lipids and aqueous phases.The regression(R2=0.959)and validation(Q2=0.960)results indicate good fitting performance and robustness of the developed model.A comparison with the predictive performance of other commercial software further proves the higher accuracy and stronger predictive ability of the developed K_(lip/w)predictive model.Thus,it can be used to predict the K_(lip/w)values of cycloalkanes,long-chain alkanes,halides(with fluorine,chlorine,and bromine as substituents),esters(without phosphate groups),alcohols(without methoxy groups),and aromatic compounds. | Miao Li Jian Li Yuchen Lu Cenyang Han Xiaoxuan Wei Guangcai Ma Haiying Yu | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 0 |
| 5 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
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