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| 1 | The First National Prevalence of Autism Spectrum Disorder in China显示文摘Autism spectrum disorder (ASD) is a complex developmental disability characterized by impaired social interaction and communication,restricted interests,and stereotypical behaviors [1,2].In addition to these core diagnostic features,children with ASD frequently present with a host of associated behavioral issues,such as intellectual disability and epilepsy,as well as feeding and sleep problems.The prevalence of ASD in the United States is about 1/59,with a significantly higher proportion in males [3].Therefore,ASD is no longer a rare disorder. | Zi Chao Zhang Junhai Han | 2020 | Neuroscience Bulletin2020，36，9： | 5 |
| 2 | Drosophila Studies on Autism Spectrum Disorders显示文摘In the past decade, numerous genes associated with autism spectrum disorders(ASDs) have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding. | Yao Tian Zi Chao Zhang Junhai Han | 2017 | Neuroscience Bulletin2017，33，6： | 4 |
| 3 | Phototransduction in Drosophila显示文摘The Drosophila visual transduction is the fastest known G protein-coupled signaling cascade and has been served as a model for understanding the molecular mechanisms of other G protein-coupled signaling cascades. Numbers of components in visual transduction machinery have been identified. Based on the functional characterization of these genes, a model for Drosophila phototransduction has been outlined, including rhodopsin activation, phosphoinoside signaling, and the opening of TRP and TRPL channels. Recently, the characterization of mutants, showing slow termination, revealed the physiological significance and the mechanism of rapid termination of light response. | TIAN Yao HU Wen TONG HuaWei HAN JunHai | 2012 | Science China(Life Sciences)2012，55，1： | 2 |
| 4 | Novel regulation of the eEF2K/eEF2 pathway:prospects of'PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation'显示文摘Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein synthesis.In the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation elongation.The activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56). | Yuqian Shen Junhai Han Zi Chao Zhang | 2021 | Journal of Molecular Cell Biology2021，13，5： | 1 |
| 5 | Research on SINS and OD Inte- grated Navigation System for Land Vehicles 显示文摘 | Luo Qiangli Han Junhai | 2011 | Navigation and Control2011，10，4： | 1 |
| 6 | Research on analysis of brand value and its positive analysis in air condition enterprises based on IAHP显示文摘 | Zhihui Han Junhai Ma | 2013 | Journal of Convergence Information Technology2013，8，1： | 1 |
| 7 | Research on Influence Factors of Brand Added Value Based on Method of IAHP and DEA显示文摘 | ZHIHUI HAN JUNHAI MA | 2013 | Advance Journal of Food Science and Technology2013，5，5： | 1 |
| 8 | Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila显示文摘Neuroligins (Nlgs ) 是在触处开发和功能起必要作用的 transmembrane 房间粘附分子。在 neuroligin 基因的基因变化与象孤独性那样的一些 neurodevelopmental 混乱被连接了。这些变异的 Nlgs 主要在 endoplasmic 蜂窝胃被保留(嗯) 。然而,位于正常 Nlg 成熟和 trafficking 下面的机制仍然保持大部分未知。这里,我们发现那果蝇 neuroligin (DNlg2 ) 2 在整个发展阶段在许多果蝇纸巾在 ER 经历解朊的劈开。包含 Y642T698 的一个区域为这个过程被要求。不成熟的非劈得开的 DNlg2 在 ER 被保留并且非功能。DNlg2 的 C 终端碎片而不是全身或非劈得开的 DNlg2 能救 dnlg2 删除导致的神经与肌的连接缺点和 GluRIIB 减小。有趣地,在 DNlg2 的联系孤独性的 R598C 变化在 DNlg2 解朊的过程导致类似的显著缺点,揭示在孤独性致病的不适当的 Nlg 劈开的一个潜在的角色并且嗯出口。一起,我们的调查结果揭开在 ER 经由解朊的劈开控制 DNlg2 成熟和 trafficking 的特定的机制,建议 Nlgs 的使不安的解朊的劈开多半贡献孤独性混乱。 | Renjun Tu Jinjun Qian Menglong Rui Nana Tao Mingkuan Sun Yan Zhuang Huihui Lv Junhai Han Moyi Li Wei Xie | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 9 | Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin hornoeostasis显示文摘 | Xiao Wang Yawen Mu Mengshi Sun Junhai Han | 2017 | Journal of Molecular Cell Biology2017，9，2： | 0 |
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