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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | Seed germination and proline accumulation in Rice ( Oryza sativa L ) as affected by salt concentrations 显示文摘 | MOMAYEZI M R ZAHARAH A R HANAFI M M | 2009 | J Trop Agric Food Sci2009，32，2： | 1 |
| 3 | Intraumbilical injection of three different uterotonics in the management for retained placenta 显示文摘 | HARARA R HANAFY S ZIDAN MS | 2011 | J Obstet Gynaecol Res2011，37，9： | 1 |
| 4 | Baclofen ester and carbamate prodrug candidates:a simultaneous chromatographic assay,resolution optimized with DryL ab显示文摘 | Hanafi R Mosad S Abouzid K | 2011 | J Pharm Biomed Anal2011，56，3： | 1 |
| 5 | Phosphorus leaching in an acid tropical soil 'recapitalized' with phosphate rock and triple superphosphate显示文摘 | Gikonyo E Zaharah A R Hanafi M M | 2010 | The Scientific World Journal2010，10，： | 1 |
| 6 | The effects of a silane coupling agent on curing characteristics and mechanical properties of bamboo fibre filled natural rubber composites 显示文摘 | Ismail Hanafi Shuhelmy S Edyham M R | 2002 | European Polymer Journal2002，38，1： | 1 |
| 7 | Cerebral inflammatory response and predictors of admission clinical grade after aneurysmal subarachnoid hemorrhage显示文摘 | Khalid A Hanafy R Morgan Stuart | 2010 | Journal of Clinical Neuroscience2010，17，1： | 1 |
| 8 | Dynamic properties and swelling behaviour of bamboo filled natural rubber composites: The effect of bonding agent 显示文摘 | Hanafi I Mohammad R E Basuki W | 2001 | Iranian Polymer Journal2001，10，6： | 1 |
| 9 | Assessment of synthetic zeolite Na A-X as sorbing barrier for strontium in a radioactive disposal facility显示文摘 | ABDEL RAHMAN R O LBRAHIM H A HANAFY M | 2010 | Chemical Engineering Journal2010，157，： | 1 |
| 10 | Maturation, fecundity and seasonality of reproduction of two commercially valuable cuttlefish, Sepia pharaonis and S. dollfusi , in the Suez Canal显示文摘 | Howaida R Gabr Roger T Hanlon Mahmoud H Hanafy Salah G El-Etreby | 1998 | Fisheries Research1998，，2： | 1 |
| 11 | Effect of epoxidized natural ruh- ber (ENR) and ethylene-co-acrylic acid copolymer on properties of silica-filled natural rubber/recycle rubber powder blends 显示文摘 | Hanafi Ismail Nordin R | 2004 | Polymer Plastics Technology and Engi- neering2004，43，2： | 1 |
| 12 | A contribution to the simulation and design optimization of photovoltaic system显示文摘 | Jaboori M G Saied M M Hanafy A A R | 1991 | IEEE Trans on Energy Conversion1991，6，： | 1 |
| 13 | Treatment of calculi in kidneys with congenital anomalies: an assessment of the efficacy of lithotripsy显示文摘 | Al-Tawheed A R Al-Awadi K A Kehinde E O Abdul Halim H Hanafi A M Ali Y | 2006 | Urol Res2006，34，： | 1 |
| 14 | Analysis of phosphate rock dissolution determining factors using principal component analysis in some acid Indonesian soils显示文摘 | Yusdar H Anuar A R Hanafi M M | 2007 | Communications in Soil Science and Plant Analysis2007，38，1： | 1 |
| 15 | Relation- ship between brain interstitial fluid tumor necrosis fac- tor- alpha and cerebral vasospasm after aneurysmal subarachnoid hemorrhage显示文摘 | Hanafy K A Stuart R M Khandji A G | 2010 | J Clin Neurosci2010，17，7： | 1 |
| 16 | Assessment of synthetic zeolite Na A - X as sorbing barrier for strontium in a radioactive disposal facility显示文摘 | Rahman R O A Ibrahim H A Hanafy Metc | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 17 | A contributionto the simulation and design optimization of photovoltaic systems显示文摘 | JABOORI M G SAIED M M HANAFY A A R | 1991 | IEEE Transactions on Energy Conversion1991，6，3： | 1 |
| 18 | Phosphorus leaching in an acid tropical soil' recapitalized' with phosphate rock and triple superphosphate 显示文摘 | Gikonyo E W Zaharah A R Hanafi M M | 2010 | The Scientific World Journal2010，，10： | 1 |
| 19 | Skewed General Variable Neighborhood Search for the Location Routing Scheduling Problem 显示文摘 | Macedo R Alves C Hanafi S | 2015 | Computers & Operations Research2015，61，： | 1 |
| 20 | Intraumbilical injection of three different uterotonics in the management of retained placenta显示文摘 | Harara R Hanafy S Zidan MS | 2011 | J Obstet Gynaecol Res2011，37，9： | 1 |
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