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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Two-Dimensional Ordered β-Sheet Lipopepfide Monolayers显示文摘 | Cavalli S Handgraaf J W Tellers E E | 2006 | J Am Chem SOe2006，128，13： | 1 |
| 3 | Real-time near-infrared fluorescence guided surgery in gynecologic oncology: A review of the current state of the art显示文摘 | Handgraaf HM Verbeek FR Tummers QG | 2014 | Gyneeol Oneol2014，135，3： | 1 |
| 4 | The use of the API 20E bacteria classification procedure to identify Pasteurellaceae strains in rodents and rabbits显示文摘 | Boot R Van den Brink Handgraaf P | 2004 | Stand J Lab Anim Sci2004，31，： | 1 |
| 5 | Social utility in ultimatum bargaining显示文摘 | Handgraaf M. J. J Dijk E. V Cremer. D. D | | 0，，03： | 1 |
| 6 | Multiseale Computer Simu- lation Studies of Water-Based Montmorillonite/Poly (ethylene oxide) Nanocomposites 显示文摘 | Toth R Voom D J Handgraaf J M | 2009 | Macromolecules2009，42，21： | 1 |
| 7 | Oxytocin modulates selection of allies in intergroup conflict显示文摘 | De Dreu CK Greer LL Handgraaf MJ | | 0，，： | 1 |
| 8 | The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans显示文摘 | De Dreu CK Greer LL Handgraaf MJ | | 0，，： | 1 |
| 9 | Justified ethicality: Observing desired counterfactuals modifies ethical perceptions and behavior显示文摘 | Shalvi S Dana J Handgraaf M J J De'Dreu C K W | 2011 | Organizational Behavior and Human Decision Processes2011，115，： | 1 |
| 10 | Social Value Orientations and the Strategic Use of Fairness in Ultimatum Bargaining 显示文摘 | Van Dijk E De Cremer D Handgraaf M J J | 2004 | Journal of Experimental Social Psychology2004，40，6： | 1 |
| 11 | Prevention of obesity and insulin resistance by estrogens requires EReα activation Ilimction-2 (ERαAF-2) , whmas ERetAF-I is dispensable 显示文摘 | Handgraaf S Riant E Fabre A | 2013 | Diabetes2013，62，12： | 1 |
| 12 | Write when hot - submit when not: Seasonal bias in peer review or acceptance 显示文摘 | Shalvi S Baas M Handgraaf M J J | 2010 | Learned Publishing2010，23，2： | 1 |
| 13 | Social value orientations and the strategic use of fairness in ultimatum bargaining显示文摘 | Van Dijk E De Cremer D Handgraaf M J J | | 0，，06： | 1 |
| 14 | Measuring social value orientation 显示文摘 | MURPHY R O ACKERMANN K A HANDGRAAF M J J | 2000 | Judgment and Decision Making2000，6，： | 1 |
| 15 | The salience of a recipient' s alter- natives: Inter- and intrapersonal comparison in uhimatum games显示文摘 | HANDGRAAF M J J | 2003 | Organizational Behavior and Human Decision Processes2003，90，： | 1 |
| 16 | The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans 显示文摘 | De Dreu CKW Greer LL Handgraaf MJJ | 2010 | Science2010，328，5984： | 1 |
| 17 | The Decision Making Individual Differences Inventory and guidelines for the study of individual differences in judgment and decision-making research显示文摘 | APPELT K C MILCH K F HANDGRAAF M J J | 2011 | Judgment and Decision Making2011，6，3： | 1 |
| 18 | Ab initio molecular dynamics study of liquid methanol显示文摘 | HANDGRAAF J W VAN ERP T S MEIJER E J | 2003 | Chemical Physics Letters2003，367，： | 1 |
| 19 | Ab into molecular dynamics study of liquid methanol显示文摘 | HANDGRAAF J W VAN ERP T S MEIJER E J | 2003 | Chem Phys Lett2003，367，： | 1 |
| 20 | From individual preference construction to group decisions:framing effects and group processes显示文摘 | Milch K F Weber E U Appelt K C Handgraaf M J J Krantz D H | 2009 | Organizational Behavior and Human Decision Processes2009，，108： | 1 |
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