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1篇 您的检索式:作者名="Hanem M.Awad"
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1Synthesis and antitumor activity of some new pyrazolo[1,5-α]pyrimidines显示文摘New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma(HCT116),prostate adenocarcinoma(PC-3) and liver carcinoma(HepG-2) using MTT cytotoxicity assay at 100 μg/mL.Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells.Whereas,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship(SAR) has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data(MS,IR,~1H NMR and ^(13)C NMR) and elemental analysis.Ashraf S.Hassan Mohamed F.Mady Hanem M.Awad Taghrid S.Hafez 2017Chinese Chemical Letters2017,28,2:1
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