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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | A genomewide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2显示文摘 | Boerwinkle E Chakraborty R | 1996 | Nat Genet1996，13，2： | 1 |
| 3 | Surface binding of aflatoxin B1 by lactic acid bacteria显示文摘 | CAROLYN A H HANI S E PASI E K | 2001 | Applied and Environmental Microbiology2001，67，7： | 1 |
| 4 | The oxidation of NdFeB magnets显示文摘 | LI Y EVANS H E HANIS I R | 2003 | Oxidation of Metals2003，59，： | 1 |
| 5 | Current-mode triple and quadruple langmuir probe methods with applications to flowing pulsed plasmas 显示文摘 | Gatsonis N A Byrne L T Zwahlen J C Pencil E J and Kamhawi Hani | 2004 | IEEE Transactions on Plasma Science2004，32，5： | 1 |
| 6 | CT 68Ge Attenuation Correction in a Combined PET/CT System:Evaluation of the Effect of lowering the CT Tube Current显示文摘 | Kamel E Hany TF Burger C | 2002 | Eur J Nucl Med Mol Imaging2002，29，3： | 1 |
| 7 | Non-suppurative myocarditis in piglets associated with porcine parvovirus infection显示文摘 | Bolt D M Hani H Muller E | 1997 | J CompPathol1997，117，2： | 1 |
| 8 | Cause and magnitude of the error induced by oral CT contrast agent in CT-based attenuation correction of PET emission studies显示文摘 | Dizendorf E Hany TF Buck A | 2003 | J Nucl Med2003，44，5： | 1 |
| 9 | CT vs 68Ge attenuation correction in a combined PET/CT system: evaluation of the effect of lowering the CT tube current显示文摘 | Kamel E Hany TF Burger C | 2002 | Eur J Nucl Med2002，29，3： | 1 |
| 10 | Fundamental foaming mecha- nisms governing the volume expansion of extruded polypropylene foams 显示文摘 | Hani E Chul B | 2004 | Joumal of applied polymer science2004，91，4： | 1 |
| 11 | Head and neck imaging with PET and PET/CT: artefacts from dental metallic implants显示文摘 | Goerres GW Hany TF Kamel E | 2002 | Eur J Nucl Med2002，29，3： | 1 |
| 12 | Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians 显示文摘 | Hani E H Clement K Velho G | 1997 | Diabetes1997，46，： | 1 |
| 13 | Fundamental Foaming Mechanism Governing the Volume Expansion of Extruded Polypropylene Foams 显示文摘 | Hani E Naguib Chul B Park N Reichelt | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 14 | A genome-wide search for human non-insulin-dependent (Type2) diabetes genes reveals a major susceptibility locus on chromosome2显示文摘 | Hanis CL Boerwinkle E Chakraborty R | 1996 | Nat Genet1996，13，： | 1 |
| 15 | Genome wide searchfor type 2 diabetes-susceptibility genes in French whites: evidence for anovel susceptibility locus for early-onset diabetes on chromosome 3q27-qterand independent replication of a type 2 diabetes locus on chromosome 1q21-q24显示文摘 | Vionnet N Hani E H Dupont S | 2000 | Am J Hum Genet2000，672，： | 1 |
| 16 | Non-suppurative myocarditis in piglets associated with porcine parvovirus infec- tion显示文摘 | BOLT D M HANI H MULLER E | 1997 | J Comp Pathol1997，117，2： | 1 |
| 17 | Catt~ic acid phenethyl a ester, 5 - lipoxygenase enzyme inhibitor alleviates diabetic atherosclerotic manitestations:Effect on vascular reaetivity and stiffness显示文摘 | Noura A H Hany M E B | 2014 | Chemico-Biological Interactions2014，，213： | 1 |
| 18 | Non-suppurative myocard it is in piglets associated with porcine parvovirus infection显示文摘 | Bolt D M Hani H Muller E | 1997 | J CompPathol1997，117，2： | 1 |
| 19 | Gastric electrical stimulation for diabetic gastroparesis is associated with autonomic and enteric nervous system changes显示文摘 | Jean L Paula E | 2001 | Gastroenterology2001，96，： | 1 |
| 20 | Cause and magnitude of the error induced by oral CT contrast agent in CT - based atten- uation correction of PET emission studies 显示文摘 | Dizendorf E Hany TF Buck A | 2003 | J Nucl Med2003，44，5： | 1 |
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