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| 1 | Hepaittis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells 显示文摘 | HanJ Ding L Yuan B | 2006 | Nucleic AcidsRes2006，34，10： | 1 |
| 2 | Avances in upper airway cough syndrome 显示文摘 | Li Y Xianghuai X Hanjing L | 2015 | Kaohsiung Med Sci2015，31，： | 1 |
| 3 | J Phys Chem A显示文摘 | HanJ Richard L Tao F M | 2004 | 108(38):7736-77432004，108，38： | 1 |
| 4 | Latent community topic analy- sis: Integration of community discovery with topic modeling 显示文摘 | Yin Z Cao L Gu Q HanJ | 2012 | ACM Transactions on Intelligent Systems and Technol- ogy2012，3，4： | 1 |
| 5 | Electroacupuncture facilitates recovery of male sexual behavior in morphine withdrawal rats显示文摘 | Cui G H Ren X W Wu L Z HanJ S Cui C L | 2004 | Neurochen Res2004，29，： | 1 |
| 6 | Preoperative evaluation of patients with liver disease显示文摘 | Hanje AJ Patel L | 2007 | Nature Clinical Practice Gastroenterology and Hepatol- ogy2007，4，5： | 1 |
| 7 | 土工格室加固砂垂直载荷下的行为显示文摘 | HanJ Yang X Leshchinsky D Parsons R L | 2008 | 中国交通运输研究委员会2008，，： | 1 |
| 8 | Levels of PCDD/Fs and DL-PCBs in selected foods and estimated dietary intake for the local residents of Luqiao and Yuhang in Zhejiang,China显示文摘 | Yang S Wu N X HanJ L | 2011 | Chemosphere2011，85，3： | 1 |
| 9 | Polychlorinated dibenzo-p-dioxins/furans and polyehlorinated biphenyls in human adipose tissue from Zhejiang Province, China 显示文摘 | Shen H T HanJ L Tie X W XuW Ren Y P Ye C S | 2009 | Chemosphere2009，74，3： | 1 |
| 10 | Onshore wind power development in China: challenges behind a successful story 显示文摘 | HANJ Y MOL A P J LU Y L | 2009 | Energy Policy2009，，37： | 1 |
| 11 | Increased PADI4 expression in blood and tissues of patients with maIignant tumors显示文摘 | Chang X HanJ Pang L | 2009 | BMC Cancer2009，9，： | 1 |
| 12 | Up-regulation of calcitonin gene-related peptide protects streptozotocin-induced diabetic hearts from ischemia/ reperfusion injury显示文摘 | Zheng LR HanJ Yao L | 2012 | IntJ Cardiol2012，156，2： | 1 |
| 13 | A MAP kinase targeted by endotoxin and hyperosmoloarity in mammalian ceils显示文摘 | HANJ Lee JD Bibbs L Ulevitch RJ | | 0，，： | 1 |
| 14 | Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor sig?naling in hepatoma cells显示文摘 | HanJ Ding L Yuan B | 2006 | Nucleic Acids Res2006，34，10： | 1 |
| 15 | Detection of pervascular nodular hepato- cellur carcinomas:value of triphasic helical CT compared withiodizedoil CT显示文摘 | Choibi L Leeh J Hanj K | 2012 | A JR2012，157，2： | 1 |
| 16 | Interaction of antiflammin-I with uteroglobin- binding protein induces phosphorylation of ERK1/2 in NIH 3T3 cells显示文摘 | Li C HanJ Li L | 2007 | Peptides2007，28，11： | 1 |
| 17 | Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species显示文摘 | CHEN S L Y AO H HANJ P | 2010 | PLoS One2010，5，1： | 1 |
| 18 | Cystic fibrosis patients on cystic fibrosis transmembrane conductance regulator modulators have a reduced incidence of cirrhosis显示文摘BACKGROUND Cystic fibrosis transmembrane conductance regulator(CFTR)modulators significantly improve pulmonary function in patients with cystic fibrosis(CF)but the effect on hepatobiliary outcomes remains unknown.We hypothesized that CF patients on CFTR modulators would have a decreased incidence of cirrhosis compared to patients not on CFTR modulators or on ursodiol.AIM To investigate the effect of CFTR modulators on the development of cirrhosis in patients with CF.METHODS A retrospective analysis was performed using Truven MarketScan from January 2012 through December 2017 including all patients with a diagnosis of CF.Patients were excluded if they underwent a liver transplantation or if they had other etiologies of liver disease including viral hepatitis or alcohol use.Subjects were grouped by use of CFTR modulators,ursodiol,dual therapy,or no therapy.The primary outcome was development of cirrhosis.Kaplan-Meier curves estimated the incidence of cirrhosis and log-rank tests compared incidence curves between treatment groups.RESULTS A total of 7201 patients were included,of which 955(12.6%)used a CFTR modulator,529(7.0%)used ursodiol,105(1.4%)used combination therapy,and 5612(74.3%)used neither therapy.The incidence of cirrhosis was 0.1%at 1 year and 0.7%at 4 years in untreated patients,5.9%and 10.1%in the Ursodiol group,and 1.0%and 1.0%in patients who received both therapies.No patient treated with CFTR modulators alone developed cirrhosis.Patients on CFTR modulators alone had lower cirrhosis incidence than untreated patients(P=0.05),patients on Ursodiol(P<0.001),and patients on dual therapy(P=0.003).The highest incidence of cirrhosis was found among patients treated with Ursodiol alone,compared to untreated patients(P<0.001)or patients on Ursodiol and CFTR modulators(P=0.01).CONCLUSION CFTR modulators are associated with a reduction in the incidence of cirrhosis compared to other therapies in patients with CF. | Mitchell L Ramsey Michael R Wellner Kyle Porter Stephen E Kirkby Susan S Li Luis F Lara Sean G Kelly A James Hanje Lindsay A Sobotka | 2022 | World Journal of Hepatology2022，14，2： | 0 |
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