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| 1 | Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases显示文摘Proteases, enzymes catalyzing the hydrolysis of peptide bonds, are present at high concentrations in the gastrointestinal tract. Besides their well-known role in the digestive process, they also function as signaling molecules through the activation of protease-activated receptors(PARs). Based on their chemical mechanism for catalysis, proteases can be classified into several classes: serine, cysteine, aspartic, metallo- and threonine proteases represent the mammalian protease families. In particular, the class of serine proteases will play a significant role in this review. In the last decades, proteases have been suggested to play a key role in the pathogenesis of visceral hypersensitivity, which is a major factor contributing to abdominal pain in patients with inflammatory bowel diseases and/or irritable bowel syndrome. So far, only a few preclinical animal studies have investigated the effect of protease inhibitors specifically on visceral sensitivity while their effect on inflammation is described in more detail. In our accompanying review we describe their effect on gastrointestinal permeability. On account of their promising results in the field of visceral hypersensitivity, further research is warranted. The aim of this review is to give an overview on the concept of visceral hypersensitivity as well as on the physiological and pathophysiological functions of proteases herein. | Hannah Ceuleers Hanne Van Spaendonk Nikita Hanning Jelena Heirbaut Anne-Marie Lambeir Jurgen Joossens Koen Augustyns Joris G De Man Ingrid De Meester Benedicte Y De Winter | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 2 | Regulation of intestinal permeability: The role of proteases显示文摘The gastrointestinal barrier is-with approximately 400 m^2-the human body's largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extraintestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. | Hanne Van Spaendonk Hannah Ceuleers Leonie Witters Eveline Patteet Jurgen Joossens Koen Augustyns Anne-Marie Lambeir Ingrid De Meester Joris G De Man Benedicte Y De Winter | 2017 | World Journal of Gastroenterology2017，23，12： | 6 |
| 3 | Crown profile equations for stand-grown western hemlock trees in northwestern Oregon显示文摘 | MARSHALL D D JOHNSON G P HANN D W | 2003 | Can J For Res2003，33，11： | 1 |
| 4 | Crown profile equations for stand-grown western hemlock trees in northwestern Oregon 显示文摘 | Marshall D D Johnson G P Hann D W | 2003 | Canadian Journal of Forest Research-Revue Canadienne de Re- cherche Forestiere2003，33，11： | 1 |
| 5 | Improved secondary metabolite production in the genus Streptosporangium by optimization of the fermentation conditions显示文摘 | Chrisotph P Uwe T Hanne G | 2000 | Biotechnology2000，80，： | 1 |
| 6 | Mop-top virus, relationship to its vector 显示文摘 | HANNE G | 2008 | Am J Pot Res2008，，85： | 1 |
| 7 | Using a bootstrap method to choose the sample fraction in tail index estimation显示文摘 | de HANN L PENG L AND de VRIES C G | 2001 | Journal of Multivariate Analysis2001，76，2： | 1 |
| 8 | Snail-periphyton interactions in a prairie lacustrine wetland 显示文摘 | Hann B J Mundy C J Goldsborough L G | 2001 | Hydrobiologia2001，457，13： | 1 |
| 9 | Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells 显示文摘 | Gallia G L Tyler B M Hann C L | 2009 | Mol Cancer Ther2009，8，2： | 1 |
| 10 | Mop-top virus, relationship to its vector显示文摘 | Hanne G | 2008 | American Journal of Potato Research2008，85，： | 1 |
| 11 | Psychosocial aspects of in vitro fertilization显示文摘 | Visser A Hann G Zalmstra H | 1994 | Psychosom Obstet Gynecol1994，15，1： | 1 |
| 12 | Deinterlacing-an overview显示文摘 | HANN G D BELLERS E B | 1998 | Proceedings of the IEEE1998，86，9： | 1 |
| 13 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，162，1： | 1 |
| 14 | Surface analytical investigation of the tritium getter ZrCo after exposure to various gases显示文摘 | HEIKE G HANNS K N MICHAEL B | 1992 | Microchimica Acta1992，107，36： | 1 |
| 15 | Adefovir dipivoxil alone or in combination with lamivucline in patients with lamivudine resistant chronic hepatitis B显示文摘 | Peters M G Hann Hw H Martin P Heathcote E J Buggisch P Rubin R | 2004 | Gastroenterology2004，126，： | 1 |
| 16 | Effect of oxidative stress on cellular functions and cytosolic free calcium of rat pancreatic acinar cells显示文摘 | Hanne K S Rainer S Michael G | 1997 | Am J Physiol1997，272，： | 1 |
| 17 | Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudineresistant chronic hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 18 | Adefovir Dipivoxil Alone or in Combination with Lamivudine in Patients with Lamivudine-resistant Chronic Hepatitis B 显示文摘 | Peters M G Hann H W Martin P | 2004 | Gastroenterology2004，126，1： | 1 |
| 19 | Lipid-based amphotericin B:a review of the last 10 years of use显示文摘 | Hann I M Prentice H G | 2001 | Intern J Antimicrob Agents2001，17，3： | 1 |
| 20 | Fast normalized cross correlation for motion tracking using basis functions显示文摘 | HII A J H HANN C E CHASE J G | | 0，，02： | 1 |
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