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2篇 您的检索式：作者名="Hansjorg Hauser"

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		题名	作者	年代	出处	被引量
	1	Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes显示文摘	Aaron Ochel Marcin Cebula Mathias Riehn Upneet Hillebrand Christoph Lipps Reinhold Schirmbeck Hansjorg Hauser Dagmar Wirth	2016	Cellular & Molecular Immunology2016，13，6：	1
	2	Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability显示文摘Tumor cells display phenotypic plasticity and heterogeneity due to genetic and epigenetic variations which limit the predictability of therapeutic interventions.Chromatin modifications can arise stochastically but can also be a consequence of environmental influences such as the microenvironment of cancer cells.A better understanding of the impact and dynamics of epigenetic modulation at defined chromosomal sites is required to get access to the underlying mechanisms.We investigated the epigenetic modulations leading to cell-to-cell heterogeneity in a tumor cell line model.To this end,we analyzed expression variance in 80 genetically uniform cell populations having a single-copy reporter randomly integrated in the genome.Single-cell analysis showed high intraclonal heterogeneity.Epigenetic characterization revealed that expression heterogeneity was accompanied by differential histone marks whereas contribution of DNA methylation could be excluded.Strikingly,some clones revealed a highly dynamic,stochastically altered chromatin state of the transgene cassette which was accompanied with a metastable expression pattern.In contrast,other clones represented a robust chromatin state of the transgene cassette with a stable expression pattern.Together,these results elucidate locus-specific epigenetic modulation in gene expression that contributes to phenotypic heterogeneity of cells and might account for cellular plasticity.	Shawal Spencer Agustina Gugliotta Natascha Godecke Hansjorg Hauser Dagmar Wirth	2016	Journal of Genetics and Genomics2016，43，8：	0

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