|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 2 | Sib-pair linkage an alysis for susceptibility genes for microvascular complications among Pima India ns with type 2 diabetes显示文摘 | Imperatore G Hanson R L Pettitt D J | | 0，，： | 3 |
| 3 | Evaluating the quality of feed fats and oils and their effects on pig growth performance显示文摘Feed fats and oils provide significant amounts of energy to swine diets, but there is large variation in composition,quality, feeding value, and price among sources. Common measures of lipid quality include moisture, insolubles,and unsaponifiables(MIU), titer, and free fatty acid content, but provide limited information regarding their feeding value. Lipid peroxidation is an important quality factor related to animal growth performance and health, but maximum tolerable limits in various lipids have not been established. Several indicative assays can be used to detect the presence of various peroxidation compounds, but due to the complexity and numerous compounds produced and degraded during peroxidation process, no single method can adequately determine the extent of peroxidation. Until further information is available, using a combination of peroxide value, thiobarbituric acid reactive substances(TBARS), and anisidine value appear to provide a reasonable assessment of the extent of peroxidation in a lipid at a reasonable cost. However, fatty acid composition of the lipid being evaluated should be considered when selecting specific assays. Predictive tests can also be used to estimate the stability or susceptibility of lipids to peroxidation and include active oxygen method, oil stability index, and oxygen bomb method. A review of 16 published studies with pigs has shown an average decrease of 11.4% in growth rate, 8.8% feed intake fed isocaloric diets containing peroxidized lipids compared to diets containing unperoxidized lipids of the same source.Furthermore, serum vitamin E content was generally reduced and serum TBARS content was increased when peroxidized lipids were fed in these studies, suggesting that feeding peroxidized lipids negatively affects metabolic oxidative status of pigs. However, it is unclear if antioxidants are useful additions to lipids to maintain optimal nutritional value, or if their addition to swine diets is beneficial in overcoming a metabolic oxidative challenge. | Gerald C Shurson Brian J Kerr Andrea R Hanson | 2016 | Journal of Animal Science and Biotechnology2016，7，3： | 3 |
| 4 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 5 | Improvement in oxygenation by phenylephrine and nitric oxide in patients with adult respiratory distress syndrome 显示文摘 | Doering E B Hanson C W Reily D J | 1997 | Anesthesiology1997，87，： | 2 |
| 6 | Insertional inactivation of OprD in clinical isolates of pseudomonas aeruginosa leading to carbopenem resistance 显示文摘 | Woher D J Hanson ND Lister PD | 2004 | FEMS Microbiol Lett2004，236，1： | 1 |
| 7 | Agricultural insurance as an environmental policy tool 显示文摘 | Coble K H Hanson T Miller J C | 2003 | Journal of Agricultural and Applied Economics2003，35，2： | 1 |
| 8 | Mitochondria genome a rearrangement leads to extension and relocation of the cytochrome C oxidase Subunit I gene in sorghum显示文摘 | Bailey Serres J Hanson D K Fox T D | 1986 | Cell1986，47，： | 1 |
| 9 | Sour cherry trees response to foliar boron applications显示文摘 | HANSON E J | | Hort Sci0，26，： | 1 |
| 10 | Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development显示文摘 | Hanson R D Hess J L Yu B D | 1999 | Proc Natl Acad Sci U S A1999，96，14： | 1 |
| 11 | Breast cancer subtypes and response to docctaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial显示文摘 | Hugh J Hanson J Cheang MC | 2009 | J Clin Oucol2009，27，8： | 1 |
| 12 | Nanostructured Oxides in Chemistry显示文摘 | Fernandez G M Martinez A A Hanson J C | 2004 | Chem Rev2004，104，： | 1 |
| 13 | Isolation and purifica- tion of immunoglobulins from chicken egs using thiophilic interaction chromatography 显示文摘 | HANSEN P SCOBLE J A HANSON B | 1998 | J Immunol Met1998，215，12： | 1 |
| 14 | Some results from continuummechanics analyses of (he hydraulic fracturing process 显示文摘 | Hanson M E Shaffer R J | 1980 | Society of Petroleum Engineers Journal1980，20，2： | 1 |
| 15 | Osteogenic effects of rest inserted and continuous cyclic tensile strain on hASC lines with disparate osteodifferen-tiation capabilities显示文摘 | Hanson AD Marvel SW Bernacki SH Banes AJ van Aalst J Loboa EG | | 0，，： | 1 |
| 16 | De- velopment and Characterization of Soil Material Param- eters for Embankment Breach 显示文摘 | Hanson G J Temple D M Hunt S L Tejral R D | 2011 | Applied Engineer- ing in Agriculture2011，，4： | 1 |
| 17 | CO2 imaging with saturated planar laser-induced vibrational fluorescenee 显示文摘 | Kirby B J Hanson R K | 2001 | Appl Opt2001，40，33： | 1 |
| 18 | Testing and evaluation of 43 ' noncore' Y chromosome markers for fo- rensic casework applications 显示文摘 | HANSON EK BERDOS PN BALLANTYNE J | 2006 | J Forensic Sei2006，5，6： | 1 |
| 19 | Relative humidity around apple fruit influences its accumulation of calcium显示文摘 | Cline J A Hanson E J | 1992 | J Amer Soc Hort Sci1992，117，： | 1 |
| 20 | Predicting slips and falls considering required and available friction 显示文摘 | Hanson P J Redfem S M Mazumdar M | 1999 | Ergonomics1999，42，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员