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您的检索式：作者名="Haoying Lan"
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| 1 | Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope显示文摘We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving mouse.The 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide area.The probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution,showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving state.For example,when subjected to high-concentration CO_(2) respiration,enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving state.Comparative studies exhibit significantly weakened compensation capabilities in obese rodents.This new imaging modality can be used for investigating both normal and pathological cerebrovascular functions and shows great promise for studying cerebral activity,disorders and their treatments. | Xiaoxuan Zhong Yizhi Liang Xiaoyu Wang Haoying Lan Xue Bai Long Jin Bai-Ou Guan | 2024 | Light(Science & Applications)2024，13，1： | 0 |
| 2 | Bexarotene combined with lapatinib for the treatment of Cushing’s disease:evidence based on drug repositioning and experimental confirmation显示文摘Dear Editor,Cushing’s disease(CD)is a rare disease manifested as Cushing’s syndrome caused by adrenocorticotropic hormone(ACTH)consistently over-secreted by adrenocorticotropic adenomas,followed by stimulation of the adrenal gland to secrete considerable cortisol,triggering metabolic dysfunction,and leading to death from complications.However,pituitary adrenocorticotropic adenoma-directed drugs can only inhibit ACTH secretion or hamper tumour growth,which limits their clinical applications.Recently,Nur77(also known as NR4A1 and NGFI-Ba,a kind of nuclear receptor),an important positive transcription regulator of pro-opiomelanocortin(POMC),the precursor of ACTH,has been regarded as a promising CD target.1 Hence,it would be promising to identify a combination treatment that targets Nur77 and another CD target to cover hormone normalisation in the short term and tumour suppression or even elimination in the long term. | Haoying Yu Shuyue Ren Jingrong Wang Tingting Lv Lan Sun Guanhua Du | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 3 | Switching Phenomena of CuTCNQ Induced Mainly by the Interaction among Microcrystaline Grains显示文摘CuTCNQ organic films were prepared separately by spontaneous charge transfer(CT) reaction of Cu with TCNQ in an acetonitrile or thermally activated solid phase diffusion and CT reaction of an alternative vapor deposition of Cu and TCNQ thin films. The m | Gu Ning a1 Sheng Haoying b Lu Wu a1 Pang Shuming a2 Zhang Lan b Wei Yu a1 ( a1 Department of Biology Science and Medical Engineering,Southeast University,Nanjing 210018) ( a2 Department of Electronics Engineering, South | 1996 | Journal of Southeast University(English Edition)1996，12，1： | 0 |
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